Expression of granulocyte/ macrophage-colony-stimulating factor, lnterleukin-8 and rantes in the bronchial epithelium of mild asthmatics is down-regulated by inhaled beclomethasone dipropionate

International Archives of Allergy and Immunology

Volumn 107, Issue 1-3, 1995, Pages 428-429

  Davies, Robert J ^a   Wang, Jia Hua ^a   Trigg, Cecilia J ^a   Devalia, Jagdish L ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Beclomethasone dipropionate; Bronchial epithelium; Granulocyte macrophage colony stimulating factor; Interleukin 8; Mild asthma; RANTES

Indexed keywords

BECLOMETASONE DIPROPIONATE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 8; RANTES;

ASTHMA; BRONCHUS MUCOSA; CELL INFILTRATION; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EOSINOPHIL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY CELL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ASTHMA; BECLOMETHASONE; BIOPSY; BRONCHI; EPITHELIUM; FORCED EXPIRATORY VOLUME; GENE EXPRESSION REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-8; LYMPHOKINES; RANTES;

EID: 0029055593     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237068     Document Type: Article

References (5)

1. Marini M, Vittori E, Hollemborg J, Mottoli S: Expression of the potent inflammatory cytokines, granulocytc-macrophage-eolony-stimu-lating factor, interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma. J Allergy Clin Immunol 1992:89:1001-1009.
2. Sousa AR, Poston RN, Lane SJ, Nakhosteen JA, Lee TH: Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids. Am Rev Respir Dis 1993:147: 1557-1561.
3. Poston RN, Gall NP: Hue-saturation-intensity colour image analysis for the quantitation of immunopcroxidasc staining; in Elder IIY (ed): MICRO90. Philadelphia, Hilger. 1990. pp 525-528.
4. Howarth PH, Djukanovic R, Walla A, Wilson J, Roche W, Holgate ST: Future developments in anti-inflammatory studies. Eur Respir Rev 1991: 1:276-281.
5. Alam R: Cytokines and bronchial hyperreactivity. Agents Actions 1990;31(suppl): 147-162