Synthesis of 4″-Deoxy Motilides: Identification of a Potent and Orally Active Prokinetic Drug Candidate

Journal of Medicinal Chemistry

Volumn 38, Issue 10, 1995, Pages 1793-1798

  Lartey, Paul A ^a   Nellans, Hugh N ^a   Faghih, Ramin ^a   Petersen, Albert ^a   Edwards, Carla M ^a   Freiberg, Leslie ^a   Quigley, Sherry ^a   Marsh, Kennan ^a   Klein, Larry L ^a   Plattner, Jacob J ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8,9 ANHYDRO 4'' DEOXY 3' N ETHYL 3' NORERYTHROMYCIN B 6,9 HEMIACETAL; 8,9 ANHYDRO N ETHYLNORERYTHROMYCIN A 6,9 HEMIACETAL; 8,9 ANHYDROERYTHROMYCIN A 6,9 HEMIACETAL DERIVATIVE; ALEMCINAL; DRUG RECEPTOR; ERYTHROMYCIN; PROKINETIC AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GASTROINTESTINAL MOTILITY; INTESTINE MUSCLE; NONHUMAN; SMOOTH MUSCLE CONTRACTION;

ADMINISTRATION, ORAL; ANIMAL; BIOLOGICAL AVAILABILITY; DOGS; ERYTHROMYCIN; FEMALE; GASTROINTESTINAL MOTILITY; IN VITRO; MALE; MUSCLE, SMOOTH; RABBITS;

EID: 0029054890     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00010a024     Document Type: Article

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