Factors affecting the oral uptake and translocation of polystyrene nanoparticles: Histological and analytical evidence

Journal of Drug Targeting

Volumn 3, Issue 1, 1995, Pages 65-70

  Florence, A T ^a   Hillery, A M ^a   Hussain, N ^a   Jani, P U ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Oral uptake; Peyer's patches; Poloxamer; Polystyrene nanoparticles; Tomato lectin; Translocation

Indexed keywords

LATEX; MICROSPHERE; NANOPARTICLE; POLYSTYRENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG UPTAKE; FEMALE; HYDROPHILICITY; INTERNALIZATION; INTESTINE ABSORPTION; INTESTINE CELL; INTESTINE LYMPHATIC TISSUE; LYMPHOID TISSUE; NONHUMAN; PARTICLE SIZE; PEYER PATCH; PRIORITY JOURNAL; RAT;

ANIMAL; FEMALE; FLUORESCEINS; FLUORESCENCE; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; LECTINS; LYMPHATIC SYSTEM; MICROSPHERES; PARTICLE SIZE; POLYSTYRENES; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; TISSUE DISTRIBUTION; TITANIUM;

EID: 0029053808     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869509015936     Document Type: Article

References (25)

1. The transport of microspheres from gastro‐intestinal tract to inflammatory air pouches in the rat
2. Controlled vaccine release in the gut‐associated lymphoid tissues: orally administered biodegradable microspheres target the Peyer's patches
3. Particulate delivery: the challenge of the oral route
4. Comparative, quantitative study of lymphoid and non‐lymphoid uptake of 60nm polystyrene particles
5. The organ uptake of intravenously administered colloidal particles can be altered using a nonionic surfactant (poloxamer 338)
6. The effect of hydrophilic coatings on the uptake of colloidal particles by the liver and by peritoneal macrophages
7. The uptake and translocation of latex nanospheres and microspheres after oral administration to rats
8. Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and Particle size dependency
9. Further histological evidence of the gastrointestinal absorption of polystyrene nanospheres in the rat
10. Nanosphere and microsphere uptake via Peyer's patches: observation of the rate of uptake in the rat after a single dose
11. Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration
12. The quantitation of absorption of micropaticles into the intestinal lymph of Wistar rats
13. Protein adsorption on Pluronic copolymer‐coated polystyrene particles
14. Changing needs in drug delivery in the era of peptide and protein drugs
15. Intestinal barrier to large particulates in mice
16. Accumulation of 2μm latex particles in mouse Peyer's patches during chronic latex feeding
17. Accumulation of latex in Peyer's patches and its subsequent appearance in villi and mesenteric lymph nodes
18. Intestinal barrier to large particulate in mice
19. Estimation of the turnover time of intestinal mucus layer in the rat in situ loop
20. Bioadhesion by means of specific binding of tomato lectin
21. The potential use of tomato lectin for oral drug delivery: lectin binding to rat small intestine in vitro
22. The potential use of tomato lectin for oral drug delivery: mechanism of uptake in vitro
23. Particulate and Lymphatic Drug Delivery
24. Effect of various poloxamer coatings on in vitro adhesion of isohexyl‐cyanoacrylate nanospheres to rat ileal segments under liquid flow