Increased anti-influenza a virus cytotoxic t cell activity following vaccination of the chronically iii elderly with live attenuated or inactivated influenza virus vaccine

Journal of Infectious Diseases

Volumn 172, Issue 1, 1995, Pages 1-10

  Gorse, Geoffrey J ^a,b,c   Campbell, Mark J ^a,b,c   Otto, Esther E ^a,b,c   Powers, Douglas C ^a,b,c   Chambers, Guy W ^a,b,c   Newman, Frances K ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Forest Park Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE;

AGED; ANTIBODY RESPONSE; ARTICLE; CHRONIC DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DOUBLE BLIND PROCEDURE; ELDERLY CARE; HUMAN; INFLUENZA VACCINATION; INFLUENZA VIRUS A; INTRAMUSCULAR DRUG ADMINISTRATION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VIRUS SHEDDING;

AGED; CHRONIC DISEASE; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; HUMANS; INFLUENZA A VIRUS; INFLUENZA VACCINES; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS; VACCINES, ATTENUATED; VACCINES, INACTIVATED; VACCINES, SYNTHETIC;

EID: 0029053586     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/172.1.1     Document Type: Article

References (40)

1. Arden NH, Cox NJ, Schonberger LB. Prevention and control of influenza: part 1, vaccines. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 1993; 42(RR-6); 1-14.
2. Arden NH, Cox NJ, Schonberger LB Final results: medicare influenza vaccine demonstration-selected states, 1988-1992. MMWR Morb Mortal Wkly Rep 1993;42:601-4.
3. Nichol KL, Margolis KL, Wuorenma J, Von Sternberg T. The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community. N Engl J Med 1994;331:778-84.
4. Glezen WP. Serious morbidity and mortality associated with influenza epidemics. Epidemiol Rev 1982;4:25-44.
5. Patriarca PA, Weber JA, Rarker RA, et al. Efficacy of influenza vaccine in nursing homes: reduction in illness and complications during an influenza A (H3N2) epidemic. JAMA 1985;253:1136-9.
6. Kuwano K, Scott M, Young JF, Ennis FA. HA2 subunit of influenza A HI and H2 subtype viruses induces a protective crossreactive cytotoxic T lymphocyte response. J Immunol 1988;140:1264-8.
7. Lukacher AC, Braciale VL, Braciale TJ. In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific. J Exp Med 1984; 160:814-26.
8. Yap KL, Ada GL. The recovery of mice from influenza virus infection: adoptive transfer of immunity with immune T lymphocytes. Scand J Immunol 1978;7:389-97.
9. Yap KL, Ada GL, McKenzie 1FC. Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus. Nature 1978; 273:238-9.
10. McMichael AJ, Gotch FM, Noble GR, Bearc PAS. Cytotoxic T cell immunity to influenza. N Engl J Med 1983;309:13-7.
11. Gorse GJ, Belshe RB. Enhanced lymphoproliferation to influenza A virus following vaccination of older, chronically ill adults with live-attenuated viruses. Scand J Infect Dis 1991;23:7-17.
12. Gorse GJ, Belshe RB. Enhancement of anti-influenza A virus cytotoxicity following influenza A virus vaccination in older chronically ill adults. J Clin Microbiol 1990;28:2539-50.
13. Webster RG, Askonas BA. Cross-protcction and cross-reactive cytotoxic T cells induced by influenza virus vaccines in mice. Eur J Immunol 1980;10:396-401.
14. Edwards KM, Dupont WD, Westrich MK, Plummer WD Jr, Palmer PS, Wright PF. A randomized controlled trial of cold-adapted and inactivated vaccines for the prevention of influenza A disease. J Infect Dis 1994;169:68-76.
15. Treanor JJ, Mattison HR, Dumyati G, et al. Protective efficacy of combined live intranasai and inactivated influenza A virus vaccines in the elderly. Ann Intern Med 1992; 117:625-33.
16. Maassab HF. Biologic and immunologic characteristics of cold-adapted influenza virus. J Immunol 1969; 102:728-32.
17. Cox NJ, Maassab HF, Kendal AP. Comparative studies of wild-type and cold-mutant (temperature-sensitive) influenza viruses: non-random reassortment of genes during preparation of live virus vaccine candidates by recombination at 25° between recent H3N2 and H1N1 epidemic strains and cold-adapted A/Ann Arbor/6/60. Virology 1979;97:190-4.
18. Gorse GJ, Belshe RB, Munn NJ. Local and systemic antibody responses in high-risk adults given live-attenuated and inactivated influenza A virus vaccines. J Clin Microbiol 1988;26:911-8.
19. Katz S, Downs TD, Cash HR, Grotz RC. Progress in development of the index of ADL. Gerontologist 1970; 10:20-30.
20. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest Suppl 1968;21:77-89.
21. Belshe RB, Van Voris LP, Mufson MA. Parenteral administration of live respiratory syncytial virus vaccine: results of a field trial. J Infect Dis 1982;145:311-9.
22. Gorse GJ, Belshe RB, Munn NJ. Safety of and serum antibody response to cold-recombinant influenza A and inactivated trivalent influenza virus vaccines in older adults with chronic disease. J Clin Microbiol 1986;24:336-42.
23. Reed LJ, Muench H. Simple method of estimating 50 percent end points. Am J Hyg 1938;27:493-7.
24. Gorse GJ, Kopp WC. Modulation by immunosuppressive agents of peripheral blood mononuclear cell responses to influenza A virus. J Lab Clin Med 1987;110:592-601.
25. World Health Organization. The hemagglutination inhibition test for influenza viruses. Atlanta: Centers for Disease Control, 1975.
26. Wells MA, Ennis FA, Albrecht P. Recovery from a viral respiratory infection. II. Passive transfer of immune spleen cells to mice with influenza pneumonia. J Immunol 1981;126:1042-6.
27. Powers DC. Influenza A virus-specific cytotoxic T lymphocyte activity declines with advancing age. J Am Geriatr Soc 1993;41:1-5.
28. Mbawuike IN, Lange AR, Couch RB. Diminished influenza A virus specific MHC class 1—restricted cytotoxic T lymphocyte activity among elderly persons. Viral Immunol 1993;6:55-64.
29. Powers DC, Belshe RB. Effect of age on cytotoxic T lymphocyte memory as well as serum and local antibody responses elicited by inactivated influenza virus vaccine. J Infect Dis 1993; 167:584-92.
30. Powers DC. Increased immunogenicity of inactivated influenza virus vaccine containing purified surface antigen compared with whole virus in elderly women. Clin Diagn Lab Immunol 1994; 1:16-20.
31. Powers DC, Belshe RB. Vaccine-induced antibodies to heterologous influenza A H1N1 viruses: effects of aging and original antigenic sin. J Infect Dis 1994;169:1125-9.
32. Rouse BT, Norley S, Martin S. Antiviral cytotoxic T lymphocyte induction and vaccination. Rev Infect Dis 1988; 10:16-33.
33. Biddison WE, Shaw S, Nelson DL. Virus specificity of human influenza virus-immune cytotoxic T cells. J Immunol 1979;122:660-4.
34. Kaplan DR, Griffith K, Braciale VL, Braciale TJ. Influenza virus-specific human cytotoxic T cell clones: heterogeneity in antigenic specificity and restriction by class II MHC products. Cell Immunol 1984;88:193-206.
35. Lamb JR, Eckels DD, Lake P, Johnson AH, Hartzman RJ, Woody JN. Antigen-specific human T lymphocyte clones. Induction, antigen specificity, and MHC restriction of influenza virus immune clones. J Immunol 1982;128:233-8.
36. McMichael AJ, Askonas BA. Influenza virus-specific cytotoxic T cells in man: induction and properties of the cytotoxic cell. Eur J Immunol 1978;8:705-11.
37. Snyder MH, Betts RF, DeBorde D, et al. Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines. J Virol 1988;62:488-95.
38. Ennis FA, Yi-Hua Q, Schild GC. Antibody and cytotoxic T lymphocyte responses of humans to live and inactivated influenza vaccines. J Gen Virol 1982;58:273-81.
39. Gorse GJ, Messner RL, Stephens ND. Association of malnutrition with nosocomial infection. Infect Control Hosp Epidemiol 1989; 10:194-203.
40. Nazari S, Dionigi R, Comodi I, et al. Preoperative prediction and quantification of septic risk caused by malnutrition. Arch Surg 1982; 117:266-73.