메뉴 건너뛰기




Volumn 682, Issue 1-2, 1995, Pages 133-143

Toxic effects of L-DOPA on mesencephalic cell cultures: protection with antioxidants

Author keywords

Ascorbic acid; Dopamine neuron; L DOPA; Neurotoxicity; Parkinson's disease; Rat mesencephalic cell culture

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; LEVODOPA; MAZINDOL; SODIUM METABISULFITE; TYROSINE 3 MONOOXYGENASE;

EID: 0029053242     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(95)00341-M     Document Type: Article
Times cited : (137)

References (58)
  • 1
    • 0025099820 scopus 로고
    • The efficacy of levodopa treatment declines in the course of Parkinson's disease: do non-dopaminergic lesions play a role?
    • (1990) Adv. Neurol. , vol.53 , pp. 83-100
    • Agid1    Graybiel2    Ruberg3
  • 3
    • 0027287928 scopus 로고
    • Suppressive effect of L-dopa on dopamine cells remaining in the ventral tegmental area of rats previously exposed to the neurotoxin 6-hydroxydopamine
    • (1993) Mov. Disord. , vol.8 , pp. 129-133
    • Blunt1    Jenner2    Marsden3
  • 4
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye-binding
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford1
  • 5
    • 0014848664 scopus 로고
    • Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: evidence for selective degeneration of catecholamine neurons
    • (1970) J. Pharmacol. Exp. Ther. , vol.174 , pp. 413-420
    • Breece1    Traylor2
  • 9
    • 0025802827 scopus 로고
    • Early initiation of levodopa treatment does not promote the development of motor response fluctuations, dyskinesia or dementia in Parkinson's disease
    • (1991) Neurology , vol.41 , pp. 622-629
    • Cedarbaum1    Gandy2    McDowell3
  • 14
    • 0021234640 scopus 로고
    • Should levodopa therapy for parkinsonism be started early or else? Evidence against early treatment
    • (1984) Can. J. Neurol. Sci. , vol.11 , pp. 2000-2006
    • Fahn1    Bressman2
  • 15
    • 0027510177 scopus 로고
    • Pre- and postsynaptic neurotoxic effects of dopamine by intrastriatal injection
    • (1993) Exp. Neurol. , vol.119 , pp. 79-88
    • Filloux1    Townsend2
  • 16
    • 0018148688 scopus 로고
    • Autoxidation versus covalent binding of quinone as the mechanism of toxicity of dopamine, 6-hydroxydopamine and related compounds towards C1300 neuroblastoma cells in vitro
    • (1978) Mol. Pharmacol. , vol.14 , pp. 644-653
    • Graham1    Tiffany2    Bell3    Gutknecht4
  • 17
    • 0018095085 scopus 로고
    • Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones
    • (1978) Mol. Pharmacol. , vol.14 , pp. 633-643
    • Graham1
  • 18
    • 84996120592 scopus 로고
    • Oxidants and the central nervous system some fundamental questions Is oxidant damage relevant to Parkinson's disease Alzheimer's disease traumatic injury or stroke?
    • (1989) Acta Neurologica Scandinavica , vol.126 , pp. 23-33
    • Halliwell1
  • 20
    • 37049230133 scopus 로고
    • 6-Hydroxydopamine: evidence for superoxide radical as an oxidative intermediate
    • (1973) Science , vol.181 , pp. 456-457
    • Heikkila1    Cohen2
  • 22
    • 0020989520 scopus 로고
    • Parkinsonism treated with levodopa, progression and mortality
    • (1983) J. Neural Transm. , vol.19 , pp. 253-264
    • Hoehn1
  • 25
    • 0023655814 scopus 로고
    • Semiquinone anion radicals from addition of amino acids, peptides and proteins to quinones derived from oxidation of catechols and catecholamines
    • (1987) J. Biol. Chem. , vol.262 , pp. 11080-11087
    • Kalyanaraman1    Pavice2    Premovie3    Sealy4
  • 26
    • 0025770366 scopus 로고
    • Ascorbic acid in mesencephalic cultures: effects on dopaminergic neurons development
    • (1991) J. Neurochem. , vol.57 , pp. 458-464
    • Kalir1    Mytilineou2
  • 29
    • 0027976087 scopus 로고
    • Vitamin E, ascorbate, glutathione, glutathione disulfide and enzimes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain
    • (1994) J. Neurochem. , vol.62 , pp. 45-53
    • Makar1    Nedergaard2    Preuss3    Gelbard4    Perumal5    Cooper6
  • 30
    • 0022574859 scopus 로고
    • Long-term follow up of early dopa treatment in Parkinson's disease
    • (1986) Ann. Neurol. , vol.19 , pp. 365-372
    • Markham1    Diamond2
  • 31
    • 0022588470 scopus 로고
    • Microtubule-associated protein 2 and tubulin are differentially distributed in the dendrites of developing neurons
    • (1986) Neuroscience , vol.17 , pp. 371-389
    • Matus1    Bernhardt2    Bodmer3    Alaimo4
  • 32
    • 0022627693 scopus 로고
    • Initiation of levodopa therapy in parkinsonian patients should be delayed until the advanced stages of the disease
    • (1986) Arch. Neurol. , vol.43 , pp. 402-405
    • Melamed1
  • 36
    • 0025063462 scopus 로고
    • Toxicity of 6-hydroxydopamine and dopamine for dopaminergic neurons in culture
    • (1990) J. Neurosci. Res. , vol.26 , pp. 428-435
    • Michel1    Hefti2
  • 37
    • 0026684221 scopus 로고
    • Toxic effects of iron for cultured mesencephalic dopaminergic neurons derived from rat embryonic brains
    • (1992) J. Neurochem. , vol.59 , pp. 118-127
    • Michel1    Vyas2    Agid3
  • 38
    • 0024399943 scopus 로고
    • 6-hydroxydopamine toxicity to dopamine neurons in culture: potentiation by the addition of superoxide dismutase andN-acetylcysteine
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 1872-1875
    • Mytilineou1    Danias2
  • 40
  • 41
    • 0027268723 scopus 로고
    • Ascorbic acid protects against levodopa-induced neurotoxicity on a catecholamine-rich human neuroblastoma cell line
    • (1993) Mov. Disord. , vol.8 , pp. 268-273
    • Pardo1    Mena2    Fahn3    de Yébenes4
  • 45
    • 0022946382 scopus 로고
    • Preservation of the substantia nigra and locus coeruleus in a patient receiving levodopa (2 Kg) plus decarboxylase inhibitor over a four-year period
    • (1986) Mov. Disord. , vol.1 , pp. 65-68
    • Quinn1    Parker2    Janota3    Marsden4
  • 47
    • 0028142763 scopus 로고
    • A vitamin as neuromodulator: ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission
    • (1994) Progr. Neurobiol. , vol.43 , pp. 537-565
    • Rebec1    Pierce2
  • 48
    • 0023814368 scopus 로고
    • Catecholamine toxicity in cerebral cortex in dissociated cell culture
    • (1988) J. Neurosci. , vol.8 , pp. 2887-2894
    • Rosenberg1
  • 50
    • 0024454694 scopus 로고
    • Micronutrient homeostatis in mammalian brain and cerebrospinal fluid
    • (1989) J. Neurochem. , vol.53 , pp. 1667-1674
    • Spector1
  • 54
    • 0006673979 scopus 로고
    • Use of intracerebral injection of 6-hydroxydopamine as a tool for morphological and functional studies on central catecholamine neurons
    • T. Malmfors, H. Thoenen, North-Holland, Amsterdam, The Netherlands
    • (1971) 6-Hydroxydopamine and Catecholamine Neurons , pp. 315-332
    • Ungerstedt1
  • 55
    • 0014731101 scopus 로고
    • Effects of 6-hydroxydopamine on catecholamine neurons in the rat brain
    • (1970) J. Neurochem. , vol.17 , pp. 269-273
    • Uretsky1    Iversen2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.