Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastro-oesophageal reflux: Evidence for a spectrum of visceral sensitivity in GORD

Gut

Volumn 37, Issue 1, 1995, Pages 7-12

  Trimble, K C ^a   Pryde, A ^a   Heading, R C ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

Gastro oesophageal reflux disease; Sensory thresholds; Symptom index; Visceral sensation

Indexed keywords

ARTICLE; CONTROLLED STUDY; ESOPHAGUS PH; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMAN; PH MEASUREMENT; PRIORITY JOURNAL;

EID: 0029052198     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.37.1.7     Document Type: Article

References (31)

1. Smout AJPM. Ambulatory monitoring of esophageal pH and pressure. In: Castell DO, ed. The esophagus. Boston: Little Brown, 1992: 161-77.
2. Weiner GJ, Richter JE, Cooper JB, Wu WC, Castell DO. The symptom index: a clinically important parameter of ambulatory 24-hour esophageal pH monitoring. Am J Gastroenterol 1988; 83: 358-61.
3. Howard PJ, Maher L, Pryde A, Heading RC. Symptomatic gastro-oesophageal reflux, abnormal oesophageal acid exposure, and mucosal acid sensitivity are three separate, though related, aspects of gastro-oesophageal reflux disease. Gut 1991; 32: 128-32.
4. Howard PJ, Pryde A, Heading RC. Relationship between gastroesophageal reflux and symptoms in patients referred for ambulatory pH-monitoring. Journal of Gastrointestinal Motility 1990; 2: 231-9.
5. Johnston BT, McFarland RJ, Collins JSA, Love AHG. Symptom index as a marker of gastro-oesophageal reflux disease. Br J Surg 1992; 79: 1054-5.
6. Singh S, Richter JE, Bradley LA, Haile JM. The symptom index: differential usefulness in suspected acid-related complaints of heartburn and chest pain. Dig Dis Sci 1993; 38: 1402-8.
7. Trimble KC, Pryde A, Heading RC. Clinical significance and natural history of the 'irritable esophagus'. Gastroenterology 1994; 106 (suppl): A199.
8. Vantrappen G, Janssens J, Ghillebert G. The irritable oesophagus - a frequent cause of angina-like pain. Lancet 1987; i: 1232-4.
9. Richter JE, Barish CF, Castell DO, Abnormal sensory perception in patients with esophageal chest pain. Gastroenterology 1986; 91: 845-52.
10. Cannon RO, Benjamin SB. Chest pain as a consequence of abnormal visceral nociception. Dig Dis Sci 1993; 38: 193-6.
11. Mearin F, Cucala M, Azpiroz F, Malagelada J-R. The origin of symptoms on the brain-gut axis in function dyspepsia. Gastroenterology 1991; 101: 999-1006.
12. Whitehead WE, Holtcotter B, Enck P, Hoelzl R, Holmes KD, Anthony J, et al. Tolerance for rectosigmoid distension in irritable bowel syndrome. Gastroenterology 1990; 98: 1187-92.
13. Ritchie J. Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut 1973; 14:125-32.
14. De Caesteckcr JS. 24 hour pH monitoring: advances and controversies. Neth J Med 1989; 12: S20-39.
15. Andreollo NA, Thompson DG, Kendall GPN, Earlam RJ. Functional relationships between cricopharyngeal sphincter and oesophageal body in response to graded intraluminal distension. Gut 1988: 29: 161-6.
16. De Caestecker JS, Pryde A, Heading RC. Site and mechanism of pain perception with oesophageal balloon distension and intravenous edrophonium in patients with oesophageal chest pain. Gut 1992; 33: 580-6.
17. Barlow JD, Thompson DG. Reproducibiliry of perception to oesophageal distension. Gut 1994; 35 (suppl 2): S8.
18. Kellow JE, Eckersley GM, Jones MP. Enhanced perception of physiological intestinal motility in the irritable bowel syndrome. Gastroenterology 1991; 101: 1621-7.
19. De Meester TR, Johnston LF, Joseph GJ, Toscano MS, Hall AW, Skinner DB. Patterns of gastroesophageal reflux in health and disease. Ann Surg 1976; 184: 459-70.
20. Patterson DJ, Graham DY, Smith JL, Schwartz JT, Alpert E, Lanza FL, et al. Natural history of benign esophageal stricture treated by dilatation. Gastroenterology 1983; 85: 346-50.
21. De Caestecker JS, Heading RC. The pathophysiology of reflux. In: Hennessy TPJ, Cuschieri A, Bennett JR, eds. Reflux oesophagitis. London: Butterworth, 1989: 1-36.
22. Drossman DA, Thompson WG, Talley NJ, Funch-Jensen P, Janssens J, Whitehead WE. Identification of sub-groups of functional gastrointestinal disorders. Gastroenterology International 1990; 3: 159-72.
23. De Meester TR, Wang CI, Wernly JA, Pellegrini CA, Little AG. Klementschitsch P, et al. Technique, indications and clinical use of 24-hour esophageal pH monitoring. J Thorac Cardiovasc Surg 1980; 79: 656.
24. Spechler SJ. Barrett's esophagus: what's new and what to do. Am J Gastroenterol 1989; 84: 220-3.
25. Schlesinger PK. Diminished esophageal acid sensitivity in patients with advanced esophagitis. Gastroenterology 1987; 92: 1622.
26. Johnsson F, Joelsson B. Reproducibility of ambulatory oesophageal pH-monitoring. Gut 1988; 29: 886-9.
27. Weiner GJ, Morgan TM, Cooper JB, Wu WC, Castell DO, Sinclair JW, et al. Ambulatory 24-hour esophageal pH-monitoring: reproducibility and variability of pH parameters. Dig Dis Sci 1988; 33: 1127-33.
28. Johnsson F, Joelsson B, Isberg PE. Ambulatory 24-hour intraoesophageal pH-monitoring in the diagnosis of gastro-oesophageal reflux disease. Gut 1987; 28: 1145-50.
29. Schindlbeck NE, Heinrich C, Konig A, Dendorfer A, Pace F, Muller-Lissner SA. Optimal thresholds, sensitivity and specificity of longterm pH-metry for the detection of gastroesophageal reflux disease. Gastroenterology 1987; 93: 85-90.
30. Cook LJ, Van Eeden A, Collins SM. Patients with irritable bowel syndrome have greater pain tolerance than normal subjects. Gastroenterology 1987; 93: 727-33.
31. Mayer EA, Raybould HE. Role of visceral afferent mechanisms in functional bowel disorders. Gastroenterology 1990; 99: 1688-704.