메뉴 건너뛰기




Volumn 1, Issue 6, 1995, Pages 528-532

A single-injection protein kinase a-directed antisense treatment to inhibit tumour growth

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA; CYCLIC AMP DEPENDENT PROTEIN KINASE;

EID: 0029050664     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm0695-528     Document Type: Article
Times cited : (132)

References (31)
  • 2
    • 0021196319 scopus 로고
    • Regulation of the cellular and subcellular concentrations and distribution of cyclic nucleotide-dependent protein kinases
    • Raven, New York
    • Lohmann, S.M. and Walter, U. Regulation of the cellular and subcellular concentrations and distribution of cyclic nucleotide-dependent protein kinases, in Advances in Cyclic Nucleotide and Protein Phosphorylation Research, vol. 18, 63-117 (Raven, New York, 1984).
    • (1984) Advances in Cyclic Nucleotide and Protein Phosphorylation Research , vol.18 , pp. 63-117
    • Lohmann, S.M.1    Walter, U.2
  • 3
    • 0025222504 scopus 로고
    • Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: New approaches to therapy [Perspec-tives in cancer research]
    • Cho-Chung, Y.S. Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: New approaches to therapy [Perspec-tives in cancer research]. Cancer Res. 50, 7093-7100 (1990).
    • (1990) Cancer Res , vol.50 , pp. 7093-7100
    • Cho-Chung, Y.S.1
  • 4
    • 77956929978 scopus 로고
    • Cyclic nucleotide-dependent protein kinases
    • Academic, New York
    • Beebe, S.J. and Corbin, J.D. Cyclic nucleotide-dependent protein kinases, in The Enzymes: Control by Phosphorylation, vol. 17, part A, 43-111 (Academic, New York, 1986).
    • (1986) The Enzymes: Control by Phosphorylation , vol.17 , pp. 43-111
    • Beebe, S.J.1    Corbin, J.D.2
  • 5
    • 0024218550 scopus 로고
    • Analysis of the cAMP-dependent protein kinase system using molecular genetic approaches
    • McKnight, G.S. et al. Analysis of the cAMP-dependent protein kinase system using molecular genetic approaches. Recent Prog. Horm. Res. 44, 307-335 (1988).
    • (1988) Recent Prog. Horm. Res , vol.44 , pp. 307-335
    • McKnight, G.S.1
  • 6
    • 0024232624 scopus 로고
    • Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3', 5'cyclic adenosine monophosphate-dependent protein kinase from human testis. Uolec
    • Levy, F.O. et al. Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3', 5'cyclic adenosine monophosphate-dependent protein kinase from human testis. Uolec. Endocrinol. 2, 1364-1373 (1988).
    • (1988) Endocrinol , vol.2 , pp. 1364-1373
    • Levy, F.O.1
  • 7
    • 0001313798 scopus 로고
    • Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase
    • Uhler, M.D. et al. Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase. Proc. natn. Acad. Sci. U.S.A. 83, 1300-1304 (1986).
    • (1986) Proc. Natn. Acad. Sci. U.S.A. , vol.83 , pp. 1300-1304
    • Uhler, M.D.1
  • 8
    • 0023000363 scopus 로고
    • Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase
    • Uhler, M.D., Chrivia, J.C. and McKnight, G.S. Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase. J. biol. Chem. 261, 15360-15363 (1986).
    • (1986) J. Biol. Chem , vol.261 , pp. 15360-15363
    • Uhler, M.D.1    Chrivia, J.C.2    McKnight, G.S.3
  • 9
    • 0022894653 scopus 로고
    • A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase
    • Showers, M.O. and Maurer, R.A. A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase. J. biol. Chem. 261, 16288-16291 (1986).
    • (1986) J. Biol. Chem , vol.261 , pp. 16288-16291
    • Showers, M.O.1    Maurer, R.A.2
  • 10
    • 0025343605 scopus 로고
    • Molecular cloning of a unique tissue-specific protein kinase (Cy) from human testis—representing a third isoform for the catalytic subunit of the cAMP-dependent protein kinase
    • Beebe, S.J. et al Molecular cloning of a unique tissue-specific protein kinase (Cy) from human testis—representing a third isoform for the catalytic subunit of the cAMP-dependent protein kinase. Molec. Endocrinol 4, 465-475 (1990).
    • (1990) Molec. Endocrinol , vol.4 , pp. 465-475
    • Beebe, S.J.1
  • 11
    • 0024285903 scopus 로고
    • A unique mRNA species for a regulatory subunit of cAMP-dependent protein kinase is specifically induced in haploid germ cells
    • Oyen, O. etal. A unique mRNA species for a regulatory subunit of cAMP-dependent protein kinase is specifically induced in haploid germ cells. FEBS Lett. 229, 391-394 (1988).
    • (1988) FEBS Lett , vol.229 , pp. 391-394
    • Oyen, O.E.1
  • 12
    • 0011564219 scopus 로고
    • Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase
    • Clegg, C.H., Cadd, G.G. and McKnight, G.S. Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase. Proc. natn. Acad. Sci. US.A. 85, 3703-3707 (1988).
    • (1988) Proc. Natn. Acad. Sci. US.A. , vol.85 , pp. 3703-3707
    • Clegg, C.H.1    Cadd, G.G.2    McKnight, G.S.3
  • 13
    • 0025221258 scopus 로고
    • Holoenzymes of cAMP-dependent protein kinase containing the neural form of type I regulatory subunit have an increased sensitivity to cyclic nucleotides
    • Cadd, G.G., Uhler, M.D. and McKnight, G.S. Holoenzymes of cAMP-dependent protein kinase containing the neural form of type I regulatory subunit have an increased sensitivity to cyclic nucleotides. J. biol. Chem. 265, 19502-19506 (1990).
    • (1990) J. Biol. Chem , vol.265 , pp. 19502-19506
    • Cadd, G.G.1    Uhler, M.D.2    McKnight, G.S.3
  • 14
    • 0020677964 scopus 로고
    • Compartmentalization of regulatory subunits of cyclic adenosine 3', 5'-monophosphate-dependent protein kinases in MCP-7 human breast cancer cells
    • Kapoor, C.L. and Cho-Chung, Y.S. Compartmentalization of regulatory subunits of cyclic adenosine 3', 5'-monophosphate-dependent protein kinases in MCP-7 human breast cancer cells. Cancer Res. 43, 295-302 (1983).
    • (1983) Cancer Res , vol.43 , pp. 295-302
    • Kapoor, C.L.1    Cho-Chung, Y.S.2
  • 15
    • 0022363913 scopus 로고
    • Cyclic-AMP-dependent protein kinase type II is associated with the golgi complex and with centro- somes
    • Nigg, E.A., Schafer, G., Hilz, H. and Eppenberger, H.M. Cyclic-AMP-dependent protein kinase type II is associated with the golgi complex and with centro- somes. Cell 41, 1039-1051 (1985).
    • (1985) Cell , vol.41 , pp. 1039-1051
    • Nigg, E.A.1    Schafer, G.2    Hilz, H.3    Eppenberger, H.M.4
  • 16
    • 0023689402 scopus 로고
    • CAMP-dependent protein kinase: Prototype for a family of enzymes
    • Taylor, S.S. et al cAMP-dependent protein kinase: Prototype for a family of enzymes. FASEB J. 2, 2677-2685 (1988).
    • (1988) FASEB J , vol.2 , pp. 2677-2685
    • Taylor, S.S.1
  • 17
    • 0027499174 scopus 로고
    • An antisense ollgodeoxynucleotide that depletes RIa subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells
    • Yokozaki, H. et al An antisense ollgodeoxynucleotide that depletes RIa subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells. Cancer Res. 53, 868-872 (1993).
    • (1993) Cancer Res , vol.53 , pp. 868-872
    • Yokozaki, H.1
  • 18
    • 0025980027 scopus 로고
    • Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynu- cleotide of cAMP-dependent protein kinase
    • Tortora, G, Yokozaki, H., Pepe, S., Clair, T. and Cho-Chung, Y.S. Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynu- cleotide of cAMP-dependent protein kinase. Proc. natn. Acad. Sci. US.A. 88, 2011-2015 (1991).
    • (1991) Proc. Natn. Acad. Sci. US.A. , vol.88 , pp. 2011-2015
    • Tortora, G.1    Yokozaki, H.2    Pepe, S.3    Clair, T.4    Cho-Chung, Y.S.5
  • 19
    • 0023572029 scopus 로고
    • Molecular cloning, cDNA structure and deduced amino acid sequence for A type I regulatory subunit of cAMP-dependent protein kinase from human testis
    • Sandberg, M., Tasken, K., 0yen, O., Hansson, V, and Jahnsen, T. Molecular cloning, cDNA structure and deduced amino acid sequence for A type I regulatory subunit of cAMP-dependent protein kinase from human testis. Biochem. biophys. Res. Commun. 149, 939-945 (1987).
    • (1987) Biochem. Biophys. Res. Commun , vol.149 , pp. 939-945
    • Sandberg, M.1    Tasken, K.2    Yen, O.3    Hansson, V.4    Jahnsen, T.5
  • 20
    • 0025012835 scopus 로고
    • An antisense oligodeoxynu- cleotide targeted against the type RIIp regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects
    • Tortora, G., Clair, T. and Cho-Chung, Y.S. An antisense oligodeoxynu- cleotide targeted against the type RIIp regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects. Proc. natn. Acad. Sci. U.S.A. 87, 705-708 (1990).
    • (1990) Proc. Natn. Acad. Sci. U.S.A. , vol.87 , pp. 705-708
    • Tortora, G.1    Clair, T.2    Cho-Chung, Y.S.3
  • 21
    • 0016703354 scopus 로고
    • Reversible autophosphorylation of a cyclic 3', 5'-AMP-dependent protein kinase from bovine cardiac muscle
    • Rosen, O.M. and Erlichman, J. Reversible autophosphorylation of a cyclic 3', 5'-AMP-dependent protein kinase from bovine cardiac muscle. J. biol. Chem. 250, 7788-7794 (1975).
    • (1975) J. Biol. Chem , vol.250 , pp. 7788-7794
    • Rosen, O.M.1    Erlichman, J.2
  • 22
    • 0027456590 scopus 로고
    • 8-Cl-cAMP induces truncation and down-regulation of the RIa subunit and up-regulation of the RIIe subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells
    • Rohlff, C, Clair, T. and Cho-Chung, Y.S. 8-Cl-cAMP induces truncation and down-regulation of the RIa subunit and up-regulation of the RIIe subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. J. biol Chem. 268, 5774-5782 (1993).
    • (1993) J. Biol Chem. , vol.268 , pp. 5774-5782
    • Rohlff, C.1    Clair, T.2    Cho-Chung, Y.S.3
  • 23
    • 0023880224 scopus 로고
    • Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs
    • Tagliaferri, P., Katsaros, D., Clair, T., Neckers, L., Robins, R.K. and Cho-Chung, Y.S, Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs. J. biol Chem. 263, 409-416 (1988).
    • (1988) J. Biol Chem. , vol.263 , pp. 409-416
    • Tagliaferri, P.1    Katsaros, D.2    Clair, T.3    Neckers, L.4    Robins, R.K.5    Cho-Chung, Y.S.6
  • 24
    • 0023038786 scopus 로고
    • Identification of a ternary complex between cAMP and a trimeric form of cAMP-dependent protein kinase
    • Connelly, P.A., Hastings, T.G. and Reimann, E.M. Identification of a ternary complex between cAMP and a trimeric form of cAMP-dependent protein kinase. J. biol Chem. 261, 2325-2330 (1986).
    • (1986) J. Biol Chem. , vol.261 , pp. 2325-2330
    • Connelly, P.A.1    Hastings, T.G.2    Reimann, E.M.3
  • 25
    • 0023646087 scopus 로고
    • Purification and characterization of an inactive form of cAMP-dependent protein kinase containing bound cAMP
    • Cobb, C.E., Beth, A.H. and Corbin, J.D. Purification and characterization of an inactive form of cAMP-dependent protein kinase containing bound cAMP. J. biol Chem. 262, 16566-16574 (1987).
    • (1987) J. Biol Chem. , vol.262 , pp. 16566-16574
    • Cobb, C.E.1    Beth, A.H.2    Corbin, J.D.3
  • 26
    • 0026340913 scopus 로고
    • Hormonal activation of gene transcription in ras-transformed NIH3T3 cells overexpressing RII„ and RIIP subunits of the cAMP-dependent protein kinase
    • Otten, A.D., Parenteau, L.A., Doskeland, S. and McKnight G.S. Hormonal activation of gene transcription in ras-transformed NIH3T3 cells overexpressing RII„ and RIIP subunits of the cAMP-dependent protein kinase. J. biol Chem. 266, 23074-23082 (1991).
    • (1991) J. Biol Chem. , vol.266 , pp. 23074-23082
    • Otten, A.D.1    Parenteau, L.A.2    Doskeland, S.3    McKnight, G.S.4
  • 27
    • 84993919295 scopus 로고
    • Introducing an autophosphorylation site mutation in the RII? Regulatory subunit of cAMP-dependent protein kinase abolishes the RII0-mediated regulatory function
    • Nesterova, M., Budillon, A., Pepe, S., Cereseto, A. and Cho-Chung, Y.S. Introducing an autophosphorylation site mutation in the RII? regulatory subunit of cAMP-dependent protein kinase abolishes the RII0-mediated regulatory function. FASEB J, 8, A1328 (1994) (abstract).
    • (1994) FASEB J , vol.8 , pp. A1328
    • Nesterova, M.1    Budillon, A.2    Pepe, S.3    Cereseto, A.4    Cho-Chung, Y.S.5
  • 28
    • 0017883364 scopus 로고
    • Presence of the sites for interacting with cyclic AMP and with catalytic subunit on small fragments of protein kinase regulatory subunit
    • Srivastava, A.K. and Stellwagen, R.H. Presence of the sites for interacting with cyclic AMP and with catalytic subunit on small fragments of protein kinase regulatory subunit. J, biol. Chem. 253, 1752-1755 (1978).
    • (1978) J, Biol. Chem , vol.253 , pp. 1752-1755
    • Srivastava, A.K.1    Stellwagen, R.H.2
  • 29
    • 0028019410 scopus 로고
    • Gene inhibition using antisense oligodeoxynucleotides
    • Wagner, R.W. Gene inhibition using antisense oligodeoxynucleotides. Nature 372, 333-335 (1994).
    • (1994) Nature , vol.372 , pp. 333-335
    • Wagner, R.W.1
  • 30
    • 0026335873 scopus 로고
    • In vivo studies with phosphorothioate oligonucleotides: Pharmacokinetics prologue
    • Iversen, P. In vivo studies with phosphorothioate oligonucleotides: Pharmacokinetics prologue. Anti-Cancer Drug Des. 6, 531-538 (1991).
    • (1991) Anti-Cancer Drug Des. , vol.6 , pp. 531-538
    • Iversen, P.1
  • 31
    • 0023038399 scopus 로고
    • CAMP-dependent protein kinases I and II: Divergent turnover of subunits
    • Weber, W. and Hilz, H. cAMP-dependent protein kinases I and II: Divergent turnover of subunits. Biochemistry 25, 5661-5667 (1986).
    • (1986) Biochemistry , vol.25 , pp. 5661-5667
    • Weber, W.1    Hilz, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.