α-tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells

Free Radical Biology and Medicine

Volumn 19, Issue 2, 1995, Pages 177-187

  Mabile, Laurence ^a   Fitoussi, Guylène ^a   Periquet, Brigitte ^a   Schmitt, Anne ^a   Salvayre, Robert ^a   Nègre Salvayre, Anne ^a  

^a UNIVERSITÉ PAUL SABATIER   (France)

Author keywords

Atherosclerosis; Calcium; Cytotoxicity; Endothelial cells; Free radicals; Low density lipoproteins; Oxidized LDL; Trolox; Tocopherol

Indexed keywords

ALPHA TOCOPHEROL; LOW DENSITY LIPOPROTEIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TROLOX C;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; ATHEROMA; ATHEROSCLEROSIS; CALCIUM TRANSPORT; CELL DEATH; CELL PROTECTION; ENDOTHELIUM CELL; LIPID PEROXIDATION; MACROPHAGE FUNCTION; NONHUMAN; PRIORITY JOURNAL; VASCULAR LESION;

ANIMAL; ANTIOXIDANTS; CALCIUM; CATTLE; CELLS, CULTURED; CHROMANS; COMPARATIVE STUDY; ENDOTHELIUM, VASCULAR; HUMAN; KINETICS; LIPID PEROXIDATION; LIPOPROTEINS, LDL; OXIDATION-REDUCTION; SUPPORT, NON-U.S. GOV'T; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VITAMIN E;

EID: 0029049568     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(95)00006-J     Document Type: Article

References (56)

1. The low density lipoprotein pathway and its relation to atherosclerosis
2. Lipoprotein metabolism in the macrophage
3. The pathogenesis of atherosclerosis-an update
4. Modifications of human serum LDL by oxidation
5. The role of altered lipoproteins in the pathogenesis of atherosclerosis
6. Dyslipemia as a risk factor for cardiovascular disease and untimely death: The Framingham study
7. Role of oxidized LDL in atherogenesis
8. Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits
9. Evidence for the presence of oxidatively modified LDL in atherosclerotic lesions of rabbit and man
10. Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit
11. Role of oxidatively modified LDL in atherosclerosis
12. The role of lipid peroxidation and oxidative modification of LDL
13. Morphological changes in atherosclerosis and the effects of hyperlipidemia on arterial wall
14. The sequence of cell and matrix changes in atherosclerotic lesions of coronary arteries in the first forty years of life
15. Injury to human endothelial cells in culture induced by LDL
16. Low density lipoproteins induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture
17. Toxicity of enzymatically oxidized LDL
18. Lipoxygenase-mediated transformation of human LDL to an oxidized and cytotoxic complex
19. Lipid peroxidation and endothelial cell injury: Implications in atherosclerosis
20. Minimally modified LDL stimulates monocyte endothelial cell interactions
21. Irradiated LDL as a model system for the study of the biological effects of lipid peroxides on cultured cells. I. Chemical modifications of irradiated low density lipoproteins
22. Wavelength dependence of photoinduced peroxidation and cytotoxicity of LDL
23. Beyond cholesterol
24. UV-B induced photoperoxidation of lipids of human LDL and HDL
25. UV-treated LDL as a model system for the study of the biological effects of lipid peroxides on cultured cells 2 Uptake and cytotoxicity of UV-peroxidized LDL on lymphoid cell lines
26. Protective effect of 17β-estradiol against the cytotoxicity of minimally oxidized LDL to cultured bovine aortic endothelial cells
27. UV-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cell culture 4 Calcium is involved in the cytotoxicity of UV-treated LDL on lymphoid cell lines
28. A delayed and sustained rise of cytosolic calcium is elicited by oxidized LDL in cultured bovine aortic endothelial cells
29. Mechanism of cell death
30. 2+ in toxic cell killing
31. The role of calcium in lethal cell injury
32. Probucol inhibits oxidative modifications of LDL
33. Flavonoids inhibit the oxidation of LDL by macrophages
34. Phenothiazines inhibit copper and endothelial cell-induced peroxidation of LDL
35. Protective effect of a-tocopherol, ascorbic acid and rutin against peroxidative stress induced by oxidized lipoproteins on lymphoid cell lines
36. UV-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cell culture 3 The protective effect of antioxidants (probucol catechin vitamin E) against the cytotoxicity of oxidized LDL occurs in two different ways
37. 2+ channel blockers (nifedipine, diltiazem and verapamil) against the toxicity of oxidized LDL to cultured lymphoid cells
38. Quercetin prevents the cytotoxicity of oxidized LDL on lymphoid cell lines
39. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
40. Fluorescent labeling of lipoproteins
41. Lipid peroxides and human diseases
42. A simple method for the isolation and purification of total lipids from animal tissues
43. A fluorescence NK assay using flow cytometry
44. Rapid colorimetric assay for cell growth and survival: modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
45. 2+ homeostasis in Ehrlich and Yoshida carcinomas
46. Assay of the Ca pump ATPase activity of intact red blood cells
47. Determination of serum a-tocopherol (vitamin E) by HPLC
48. A rapid and simple method for the esterification of fatty acids and steroid car☐ylic acids prior to gas liquid chromatography
49. Protein measurement with the Folin phenol reagent
50. The uptake of α-tocopherol by human endothelial cells in culture
51. Fluorescent probes of cell signalling
52. Hydroxyalkenals: Cytotoxic products of lipid peroxidation
53. Calcium channels, stores and oscillations
54. Vasoconstriction: A novel activity for low density lipoprotein
55. Necrosis and apoptosis induced by oxidized LDL occur through two calcium-dependent pathways in lymphoblastoid cells