Galanin-10 years with a neuroendocrine peptide

International Journal of Biochemistry and Cell Biology

Volumn 27, Issue 4, 1995, Pages 337-349

  Bedecs, Katarina ^a   Berthold, Malin ^a   Bartfai, Tamas ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Antagonist; Chimeric peptide; Neuropeptide; Peptidase Second messengers; Receptor; Subtype

Indexed keywords

GALANIN; GALANIN DERIVATIVE; GALANIN RECEPTOR;

BEHAVIOR; BRAIN REGION; COGNITION; CYTOCHEMISTRY; DRUG RECEPTOR BINDING; FOOD INTAKE; GENE EXPRESSION REGULATION; HUMAN; NONHUMAN; REVIEW; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMAL; GALANIN; HUMAN; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; PEPTIDES; RECEPTORS, GASTROINTESTINAL HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029047878     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/1357-2725(95)00008-D     Document Type: Short Survey

References (120)

1. Galanin and the regulation of islet hormone secretion—review
2. + channel in the beta-cell?
3. Mechanism of galanin-inhibited insulin release
4. Galanin receptor in the rat pancreatic beta cell line Rin m 5F
5. Structural requirement for galanin action in the pancreatic beta cell line Rin m 5F
6. Galanin receptor in endocrine pancreas and brain—functional and molecular characterization
7. Identification of a TPA-responsive element mediating preferential transactivation of the galanin gene promoter in chromaffin cells
8. M-15 high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus locus coeruleus and spinal cord
9. Galanin—a neuroendocrine peptide
10. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes
11. Distribution and molecular heterogeneity of galanin in human, pig, guinea pig, and rat gastrointestinal tracts
12. Chromatographic evidence for high-molecular-mass galanin immunoreactivity in pig and cat adrenal glands
13. Growth hormone release in man induced by galanin, a new hypothalamic peptide
14. Galanin receptors and their second messengers in the lumbar dorsal spinal cord
15. Biological activities of two endogenously occurring N-terminally extended forms of galanin in the rat spinal cord
16. Metabolism of galanin and galanin(1-16) in isolated cerebrospinal fluid and spinal cord from rat
17. Galanin protects hippocampal neurons from the functional effects of anoxia
18. Human galanin: primary structure and identification of two molecular forms
19. Galanin and galanin extended at the N-terminus with seven and nine amino acids are produced in and secreted from the porcine adrenal medulla in almost equal amounts
20. Comparative effects of galanin on isolated smooth muscle cells from ileum in five mammalian species
21. Galanin hyperinnervates surviving neurons of the human basal nucleus of Meynert in dementias of Alzheimer's and Parkinson's disease: a hypothesis for the role of galanin in accentuating cholinergic dysfunction in dementia
22. Hyperinnervation of surviving neurons of the human basal nucleus of Meynert by galanin in dementias of Alzheimer's and Parkinson's disease
23. Solubilization and molecular characterization of active galanin receptors from rat brain
24. Galanin inhibits adenylate cyclase of rat brain membranes
25. Purification of a galanin receptor from pig brain
26. Pertussis toxin-sensitive G-protein mediates galanin's inhibition of scopo-lamine-evoked acetylcholine release in vivo and carbachol-stimulated phosphoinositide turnover in rat ventral hippocampus
27. Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor
28. Effects of central nervous system lesions on the expression of galanin a comparative in situ hybridization and immunohistochemical study
29. Co-existence of galanin and acetylcholine: is galanin involved in memory processes and dementia?
30. Coexistence of neuropeptides and “classical” neurotransmitters
31. Functional interactions of galanin and acetylcholine—relevance to memory and Alzheimer's disease
32. Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus
33. Galanin receptor antagonist-M40 and antagonist-C7 block galanin-induced feeding
34. Growth hormone (GH) release in response to GH-releasing hormone in man is 3-fold enhanced by galanin
35. + channels that are blocked by hypoglycemia-inducing sulfonylureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone
36. Galanin inhibits dopamine secretion and activates a potassium channel in pheochromocytoma cells
37. Non-additivity of adrenaline and galanin effects on Rb-86 efflux and membrane potential in mouse β-cells suggests sharing of common targets
38. + channels in insulin-secreting cells via a pertussis toxin-sensitive G-protein
39. Galanin: neuromodulatory and direct contractile effects on smooth muscle preparations
40. Transsynaptic regulation of galanin, neurotensin, and substance P in the adrenal medulla—combinatorial control by 2nd-messenger signalling pathways
41. Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo and in vitro studies
42. N-terminal galanin-(1–16) fragment is an agonist at the hippocampal galanin receptor
43. Galanin receptor and its ligands in the rat hippocampus
44. Galanin inhibits the potassium-evoked release of acetylcholine and the muscarinic receptor-mediated stimulation of phosphoinositide turnover in slices of monkey hippocampus
45. Galanin stimulates rat pituitary growth hormone secretion in vitro
46. The galanin antagonist M-15 inhibits growth hormone release in rats
47. ADP ribosylation by cholera toxin identifies three G-proteins that are activated by the galanin receptor
48. N-terminal galanin fragments inhibit the hippocampal release of acetylcholine in vivo
49. Galanin in the medial septal area impairs working memory
50. Molecular cloning of a functional human galanin receptor
51. Increase of galanin-like immunoreactivity in rat dorsal root ganglion cells after peripheral axotomy
52. Galanin message-associated peptide (GMAP)-like and galanin-like immunoreactivities—overlapping and differential distributions in the rat
53. Coexpression of galanin and adrenocorticotropic hormone in human pituitary and pituitary adenomas
54. Galanin receptors from human pituitary tumors assayed with human galanin as ligand
55. Galanin is an estrogen-inducible, secretory product of the rat anterior pituitary
56. Autoradiographic localization of binding sites for galanin and VIP in small intestine
57. Galanin receptors in the post-mortem human brain
58. Autoradiographic mapping of galanin receptors in the monkey brain
59. Distribution of galanin-binding sites in the monkey and human telencephalon: preliminary observations
60. Galanin-induced prolactin release in rats: pharmacological evidence for the involvement of alpha-adrenergic and opioidergic mechanisms
61. Galanin: stimulation of feeding induced by medial hypothalamic injection of this novel peptide
62. Hypothalamic degradation of galanin(1–29) and galanin(1–16): identification and characterization of the peptidolytic products
63. Linear and cyclic N-terminal galanin fragments and analogs as ligands at the hypothalamic galanin receptor
64. Design of chimeric peptide ligands to galanin receptors and substance-P receptors
65. Hypothalamic neuropeptide Y, galanin, and amines
66. Neurochemical-neuroendocrine systems in the brain controlling macronutrient intake and metabolism
67. Impact of a galanin antagonist on exogenous galanin and natural patterns of fat ingestion
68. Galanin: effects on basal and stimulated insulin and glucagon secretion in the mouse
69. Inhibition of insulin secretion—a fail-safe system
70. Galanin inhibits insulin secretion and induces hyperglycemia in dogs
71. Pancreatic galanin: molecular forms and anatomical locations
72. Distribution of galanin-like immunoreactivity in the gastro-intestinal tract of several mammalian species
73. Galanin-like immunoreactivity in cholinergic neurons of the septum-basal forebrain complex projecting to the hippocampus of the rat
74. Distribution of galaninlike immunoreactivity in the rat central nervous system
75. 125I-galanin binding sites in the rat central nervous system
76. Inhibition of cAMP by galanin and the chimeric galanin peptides in the human cell line Bowes
77. Anatomy and physiology of central galanin-containing pathways
78. Distribution of galanin-like immunoreactivity in the pig, rat and human central nervous system
79. Testosterone regulates galanin gene expression in the bed nucleus of the stria terminalis
80. Galanin stimulates growth hormone (GH) secretion via GH-releasing factor (GRF) in conscious rats
81. Evidence for a role of the neuropeptide galanin in spatial learning
82. Differential effects of the putative galanin receptor antagonists M15 and M35 on striatal acetylcholine release
83. Effect of endocrine manipulation on anterior pituitary galanin in the rat
84. Galanin: evidence for a hypothalamic site of action to release growth hormone
85. Galanin inhibits the muscarinic stimulation of phosphoinositide turnover in rat ventral hippocampus
86. 2+ channels
87. Galanin stimulates striatal acetylcholine release via a mechanism unrelated to cholinergic receptor stimulation
88. Galanin receptor activation attenuates norepinephrine release from rat spinal cord slices
89. Construction of a porcine adrenal medullary cDNA library and nucleotide sequence analysis of two clones encoding a galanin precursor
90. Galanin gene expression in chromaffin cells is controlled by calcium and protein kinase signaling pathways
91. Galanin binding sites in rat gastric and jejunal smooth muscle membrane preparations
92. Galanin: structure-dependent effect on pancreatic amylase secretion and jejunal strip contraction
93. Characterization of the stimulatory effect of galanin on growth hormone release from the rat anterior pituitary
94. Identification and molecular characterization of galanin receptor sites in rat brain
95. Galanin decreases the activity of locus coeruleus neurons in vitro
96. Galanin receptors inhibit the spontaneous firing of locus coeruleus neurons and interact with mu-opioid receptors
97. Variant forms of galanin isolated from porcine brain
98. Galanin-like immunoreactivity in capsaicin sensitive sensory neurons and ganglia
99. Quantitative distribution of galanin-like immunoreactivity in the rat central nervous system
100. 125I-galanin binding sites in the rat central nervous system
101. Galanin impairs acquisition but not retrieval of spatial memory in rats studied in the Morris swim maze
102. Mechanism of action of galanin on myenteric neurons
103. Galanin—a novel biologically active peptide from porcine intestine
104. Galanin inhibits insulin and corticosterone release after injection into the PVN
105. Galanin antagonist effects on cardiac vagal inhibitory actions of sympathetic stimulation in anaesthetised cats and dogs
106. Evidence for endogenous inhibition of autotomy by galanin in the rat after sciatic nerve section—demonstrated by chronic intrathecal infusion of a high affinity galanin receptor antagonist
107. Neuropeptide expression in rat dorsal root ganglion cells and spinal cord after peripheral nerve injury with special reference to galanin
108. Isolation and characterization of a complementary DNA (galanin) clone from estrogen-induced pituitary tumor messenger RNA
109. 1H NMR study of the solution conformation of the neuropeptide galanin
110. The effect of intrathecal galanin on the flexor reflex in rat: increased depression after sciatic nerve section
111. On the role of substance P, galanin, vasoactive intestinal peptide, and calcitonin gene-related peptide in mediation of spinal reflex excitability in rats with intact and sectioned peripheral nerves
112. Galanin in sensory neurons in the spinal cord
113. Characterization of a high-affinity galanin receptor in the rat anterior pituitary—absence of biological effect and reduced membrane binding of the antagonist M15 differentiate it from the brain/gut receptor
114. The effects of intrathecal galanin message associated peptide (GMAP) on the flexor reflex in rats
115. The N-terminal 1–16, but not C-terminal 17–29, galanin fragment affects the flexor reflex in rats
116. Galanin reduces release of endogenous excitatory amino acids in the rat hippocampus