Inflammation enhances peripheral μ-opioid receptor-mediated analgesia, but not μ-opioid receptor transcription in dorsal root ganglia

European Journal of Pharmacology

Volumn 279, Issue 2-3, 1995, Pages 165-169

  Schäfer, Michael ^a,b   Imai, Yasuo ^a   Uhl, George R ^a,b   Stein, Christoph ^b  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Antinociception; Dorsal root ganglion; Primary afferent neuron; Ribonuclease protection assay; Funaltrexamine; Opioid receptor

Indexed keywords

BETA FUNALTREXAMINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; FREUND ADJUVANT; MESSENGER RNA; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST; RIBONUCLEASE;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG ANTAGONISM; GENETIC TRANSCRIPTION; HINDLIMB; INFLAMMATION; MALE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SPINAL GANGLION; TOPICAL DRUG ADMINISTRATION;

AMINO ACID SEQUENCE; ANALGESIA; ANALGESICS; ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; FOOT; GANGLIA, SPINAL; INFLAMMATION; MALE; MOLECULAR SEQUENCE DATA; NALTREXONE; NARCOTIC ANTAGONISTS; PAIN MEASUREMENT; RATS; RATS, WISTAR; RECEPTORS, OPIOID, MU; RIBONUCLEASES; RNA, MESSENGER; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029047619     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00150-J     Document Type: Article

References (16)

1. Perineurial defect and peripheral opioid analgesia in inflammation
2. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
3. Multiple opiate receptor sites on primary afferent fibres
4. Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue
5. Mu antagonist and kappa agonist properties of β-funaltrexamine (β-FNA) in vivo: long-lasting spinal analgesia in mice
6. Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section
7. In situ hybridization study of μ- and κ-opioid receptor mRNAs in the rat spinal cord and dorsal root ganglia
8. Characteristics of dose-dependent antagonism by β-funaltrexamine of the antinociceptive effects of intrathecal mu agonists
9. Modification of G protein-coupled functions by low-pH pretreatment of membranes from NG108-15 cells: increase in opioid efficacy by decreased inactivation of G proteins
10. Peripheral mechanisms of opioid analgesia
11. Peripheral opioid receptors mediating antinociception in inflammation
12. Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation
13. The somatotopic organization of primary afferent terminals in the superficial laminae of the dorsal horn of the rat spinal cord
14. Cloning and pharmacological characterization of a rat μ opioid receptor
15. 3-1 cells is associated with unchanged receptor messenger RNA (mRNA) levels and altered mRNA activity
16. μ-Opiate receptor: cDNA cloning and expression