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6
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0025119185
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Ligand-gated ion channels in the brain: the amino acid receptor family
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(1990)
Neuron
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, pp. 383-392
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Betz1
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8
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0025648026
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A single amino acid exchange alters the pharmacology of neonatal rat glycine receptor subunit
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(1990)
Neuron
, vol.5
, pp. 867-873
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Kuhse1
Schmieden2
Betz3
-
9
-
-
0027996651
-
The spastic mouse: aberrant splicing of glycine receptor β subunit mRNA caused by intronic insertion of l1 element
-
of special interest, This study revealed the cause underlying the mouse mutant spastic, high-lighting the physiological significance of the GlyR β subunit for receptor expression in vivo.
-
(1994)
Neuron
, vol.13
, pp. 1003-1015
-
-
Mühlhardt1
Fischer2
Gass3
Simon-Chazottes4
Guenet5
Kuhse6
Betz7
Becker8
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12
-
-
0024225307
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Glycine receptor heterogeneity in rat spinal cord during postnatal development
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(1988)
EMBO J
, vol.7
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Becker1
Hoch2
Betz3
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16
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0025649599
-
Identification and functional expression of a novel ligand binding subunit of the inhibitory glycine receptor
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(1990)
J Biol Chem
, vol.265
, pp. 22317-22320
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Kuhse1
Schmieden2
Betz3
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18
-
-
0027224010
-
Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers
-
(1993)
EMBO J
, vol.12
, pp. 3729-3737
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Bormann1
Rundström2
Betz3
Langosch4
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22
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0027424165
-
Mutation of glycine receptor subunit creates β-alanine receptor responsive to GABA
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ARs.
-
(1993)
Science
, vol.262
, pp. 256-258
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-
Schmieden1
Kuhse2
Betz3
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23
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-
0026607904
-
Agonist pharmacology of neonatal and adult glycine receptor α subunits: identification of amino acid residues involved in taurine activation
-
(1992)
EMBO J
, vol.11
, pp. 2025-2032
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-
Schmieden1
Kuhse2
Betz3
-
25
-
-
0027787023
-
A receptor needs two homologous domains of the β-subunit for activation by GABA but not by pentobarbital
-
(1993)
Nature
, vol.366
, pp. 565-569
-
-
Amin1
Weiss2
-
29
-
-
0027330927
-
Mutations in the α1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder hyperekplexia
-
of outstanding interest, A conclusive genetic study identifying for the first time a mutation in the GlyR α subunit as the cause of a hereditary disease in humans. Hereditary hyperekplexia is an autosomal dominant neurologic disorder characterized by marked muscle rigidity and an exaggerated startle response. Point mutations in the gene encoding the α1 subunit of the GlyR were identified in patients from four different families. All the mutations result in the substitution by an uncharged amino acid of arginine at position 271.
-
(1993)
Nature Genet
, vol.5
, pp. 351-358
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-
Shiang1
Ryan2
Zhu3
Hahn4
O'Connel5
Wasmuth6
-
30
-
-
0028016521
-
Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia
-
of special interest, This paper elaborates on different functional alterations in hyperekplexia mutations and relates them to GlyR structure and disease phenotype.
-
(1994)
EMBO J
, vol.13
, pp. 4223-4228
-
-
Langosch1
Laube2
Rundström3
Schmieden4
Bormann5
Betz6
-
31
-
-
0028361803
-
Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor
-
of special interest, The conclusive analysis of the functional properties of the mutated α1 subunit that revealed the importance of an amino-acid residue at the M2 segment (Arg271) for ligand binding.
-
(1994)
J Biol Chem
, vol.269
, pp. 18739-18742
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-
Rajendra1
Lynch2
Pierce3
French4
Barry5
Schofield6
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34
-
-
0028921479
-
Acetylcholine receptor channel imaged in the open state
-
(1995)
Nature
, vol.373
, pp. 37-43
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-
Unwin1
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38
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-
0021287299
-
2+ from brain tissue during activity
-
(1984)
Nature
, vol.308
, pp. 734-738
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-
Assaf1
Chung2
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41
-
-
0025202331
-
Regulation of neurotransmitter receptor desensitization by protein phosphorylation
-
(1990)
Neuron
, vol.5
, pp. 555-567
-
-
Huganir1
Greengard2
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42
-
-
0025047628
-
Modulation of glycine receptor chloride channels by cAMP-dependent protein kinase in spinal trigeminal neurons
-
(1990)
Nature
, vol.348
, pp. 242-245
-
-
Song1
Huang2
-
43
-
-
0028012343
-
Modulation of inhibitory glycine receptors by phosphorylation by protein kinase C and cAMP-dependent protein kinase
-
of outstanding interest, This study reveals, for the first time, alternative modulations of GlyR function by protein kinase A and protein kinase C. Thus, phosphorylation of the GlyR may be important for regulating the efficacy of inhibitory synapses.
-
(1994)
J Biol Chem
, vol.269
, pp. 2002-2008
-
-
Vaello1
Ruiz-Gomez2
Lermas3
Mayor4
-
44
-
-
0026525239
-
Recognition domains in assembly of oligomeric membrane proteins
-
(1992)
Trends Cell Biol
, vol.2
, pp. 66-68
-
-
Hall1
-
45
-
-
0027716526
-
Assembly of the inhibitory glycine receptor: identification of amino acid sequence motifs governing subunit stoichiometry
-
of special interest, This study investigated the formation of homo-oligomeric versus hetero-oligomeric GlyRs and identified sequence motifs governing the fixed stoichiometry of α/β hetero-oligomeric receptors.
-
(1993)
Neuron
, vol.11
, pp. 1049-1056
-
-
Kuhse1
Laube2
Magalei3
Betz4
-
47
-
-
0026550596
-
Development of glycine receptor alpha subunit in cultivated rat spinal neurons: an immunocytochemical study
-
(1992)
Neurosci Lett
, vol.138
, pp. 173-178
-
-
Nicola1
Becker2
Triller3
-
50
-
-
0027723681
-
Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons
-
of outstanding interest, The molecular principles underlying synaptogenesis are of major interest. Whereas most studies concentrate on the biogenesis of the neuro-muscular junction, the authors of this report took a direct approach and investigated synapse formation between CNS neurons. The results of this paper shows that the accumulation of the receptor-associated protein gephyrin at the cell membrane precedes the formation of GlyR clusters, and demonstrates that gephyrin plays a crucial role for the synaptic localization and clustering of the GlyR.
-
(1993)
Nature
, vol.366
, pp. 745-748
-
-
Kirsch1
Wolters2
Triller3
Betz4
-
51
-
-
0028998303
-
The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton.
-
of special interest, This paper describes a method to determine receptor packing densities in postsynaptic clusters by semiquantitative confocal microscopy and demonstrates in vivo interactions of gephyrin with the cytoskeleton.
-
(1995)
J Neurosci
-
-
Kirsch1
Betz2
-
52
-
-
0028207959
-
Expression of the human glycine receptor α1 subunit in Xenopus oocytes: apparent affinities of agonists increase at high receptor densities
-
of special interest, This study demonstrates that high-level expression can alter the agonist and antagonist response properties of the GlyR.
-
(1994)
EMBO J
, vol.13
, pp. 1318-1324
-
-
Taleb1
Betz2
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53
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-
0027323367
-
Widespread expression of gephyrin a putative glycine receptor-tubulin linker protein in rat brain
-
(1993)
Brain Res
, vol.621
, pp. 301-310
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-
Kirsch1
Betz2
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57
-
-
0028801734
-
The relationship between glycine and gephyrin in synapses of the rat spinal cord
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AR subunits at individual synapses of the spinal cord.
-
(1995)
Eur J Neurosci
, vol.7
, pp. 1-11
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-
Todd1
Spike2
Chong3
Neilson4
-
58
-
-
0028580443
-
Evidence for recessive as well as dominant forms of startle disease (hyperekplexia) caused by mutations in the α1 subunit of the inhibitory glycine receptor
-
(1994)
Human Molecular Genetics
, vol.3
, pp. 2174-2179
-
-
Rees1
Andrew2
Jawad3
Qwen4
-
59
-
-
0028175530
-
Glycine receptor β subunit gene mutation in spastic mouse associated with LINE-1 element insertion
-
of special interest, This study identified the insertion of a LINE 1 element into the GlyR β gene as cause of the mouse mutant phenotype spastic.
-
(1994)
Nature Genet
, vol.7
, pp. 136-142
-
-
Kingsmore1
Giros2
Suh3
Bieniarz4
Caron5
Sedin6
-
60
-
-
0025324123
-
Disorders of the inhibitory glycine receptor: the spastic mouse
-
(1990)
FASEB J
, vol.4
, pp. 2767-2774
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Becker1
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