Remote controlled one-step production of 18F labeled butyrophenone neuroleptics exemplified by the synthesis of n.c.a. [18F] N-methylspiperone

Applied Radiation and Isotopes

Volumn 46, Issue 9, 1995, Pages 911-916

  Hamacher, Kurt ^a   Hamkens, Wilhelm ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLSPIPERONE; BUTYROPHENONE DERIVATIVE; FLUORINE 18; NEUROLEPTIC AGENT; SPIPERONE;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ISOTOPE LABELING; PRIORITY JOURNAL;

EID: 0029043855     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/0969-8043(95)00185-G     Document Type: Article

References (15)

1. 18F]-N-methylspiroperidol and PET
2. 18F]fluoroheptadecanoic acid in high yields via aminopolyether supported nucleophilic fluorination
3. Central D2-dopamine receptor occupancy in schizophrenic patient treated with antipsychotic drugs
4. 18F
5. 18F]fluoro-2-deoxy-d-glucose: an efficient automated system for the aminopolyether-supported nucleophilic fluorination
6. 18F]fluorination of N-methyl-nitrospiperone via aminopolyether supported direct nucleophilic substitution
7. 18F]methylspiperone demonstrates D2 dopamine receptor binding differences of clozapine and haloperidol
8. Optimization studies concerning the direct nucleophilic fluorination of butyrophenone neuroleptics
9. 18F]haloperidol
10. Production of fluorine-18 labeled (3-N-methyl)benperidol for PET investigation of cerebral dopaminergic receptor binding
11. 18F]benperidol binding to dopamine receptors
12. Synthesis and specific activity determinations of no-carrier-added fluorine-18 labelled butyrophenone neuroleptics benperidol, haloperidol, spiroperidol and pimpamperone
13. 18F]N methylspiroperidol PET studies to measure changes in antipsychotic drug D2-receptor occupancy in schizophrenic patients
14. 11 C-methyl-benperidol
15. Dopamine receptor occupancy and plasma haloperidol levels