Efficacy of Methylphenidate for Attention-Deficit Hyperactivity Disorder in Children with Tic Disorder

Archives of General Psychiatry

Volumn 52, Issue 6, 1995, Pages 444-455

  Gadow, Kenneth D ^a   Sverd, Jeffrey ^a,b   Sprafkin, Joyce ^a   Nolan, Edith E ^a   Ezor, Stacy N ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b Sagamore Children's Psychiat Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLPHENIDATE; PLACEBO;

ARTICLE; CHILD; CHILD BEHAVIOR; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; FEMALE; HUMAN; MALE; MINIMAL BRAIN DYSFUNCTION; PSYCHOMETRY; RATING SCALE; TASK PERFORMANCE; TIC;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; COMORBIDITY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; METHYLPHENIDATE; PARENTS; PLACEBOS; PSYCHIATRIC STATUS RATING SCALES; SEVERITY OF ILLNESS INDEX; TEACHING; TIC DISORDERS; TREATMENT OUTCOME;

EID: 0029041844     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.1995.03950180030005     Document Type: Article

References (87)

1. Bradley C. Benzedrine and Dexedrine in the treatment of children's behavior disorders. Pediatrics. 1950;5: 24–36.
2. Mattson RH, Calverly JR. Dextroamphetamine sulfate—induced dyskinesias. JAMA. 1968;204: 400–402.
3. Gadow KD. Prevalence of drug therapy. In: Werry JS, Aman M, eds. Practitioner's Guide to Psychoactive Drugs for Children and Adolescents. New York, NY: Plenum Publishing Corp; 1993: 57–74.
4. Conners CK, Eisenberg L. The effects of methylphenidate on symptomatology and learning in disturbed children. Am J Psychiatry. 1963;120: 458–464.
5. Weiss G, Minde K, Douglas V, Werry J, Sykes D. Comparison of the effects of chlorpromazine, dextroamphetamine, and methylphenidate on the behavior and intellectual functioning of hyperactive children. Can Med Assoc J. 1971;104: 20–25.
6. Golden GS. Gilles de la Tourette's syndrome following methylphenidate administration. Dev Med Child Neurol. 1974;16: 76–78.
7. Golden GS. The effect of central nervous system stimulants on Tourette syndrome. Ann Neurol. 1977;2: 69–70.
8. Pollack MA, Cohen NL, Friedhoff AJ. Gilles de la Tourette's syndrome: familial occurrence and precipitation by methylphenidate therapy. Arch Neurol. 1977;34: 630–632.
9. Abuzzahab FS, Anderson FO. Gilles de la Tourette's syndrome: cross-cultural analysis and treatment outcome. In: Abuzzahab FS, Anderson FO, eds. Gilles de la Tourette's Syndrome. St Paul, Minn, Mason Publishing Co; 1976;1: 71–79.
10. Kelman DH. Gilles de la Tourette's disease in children: a review of the literature. J Child Psychol Psychiatry. 1965;6: 219–226.
11. Meyerhoff JL. Snyder SH. Gilles de la Tourette's disease and minimal brain dysfunction: amphetamine isomers reveal catecholamine correlates in an affected patient. Psychopharmacologia. 1973;29: 211–220.
12. Singer K. Gilles de la Tourette's disease. Am J Psychiatry. 1963;120: 80–81.
13. Gadow KD, Sverd J. Stimulants for ADHD in child patients with Tourette's syndrome: the issue of relative risk. J Dev Behav Pediatr. 1990;11: 269–271.
14. Caine ED, Ludlow CL, Polinsky RJ, Ebert MH. Provocative drug testing in Tourette's syndrome: d- and l-amphetamine and haloperidol. J Am Acad Child Psychiatry. 1984;23: 147–152.
15. Feinberg M, Carroll BJ. Effects of dopamine agonists and antagonists in Tourette's disease. Arch Gen Psychiatry. 1979;36: 979–985.
16. Shapiro AK, Shapiro E. Do stimulants provoke, cause or exacerbate tics and Tourette's syndrome? Compr Psychiatry. 1981;22: 265–273.
17. Shapiro AK, Shapiro ES, Young JG, Feinberg TE. Gilles de la Tourette Syndrome. 2nd ed. New York, NY: Raven Press; 1988.
18. Lowe TL, Cohen DJ, Detlor J, Kremenitzer MW, Shaywitz BA. Stimulant medications precipitate Tourette's syndrome. JAMA. 1982;247: 1729–1731.
19. Comings DE, Comings BG. A controlled study of Tourette syndrome, I: attentiondeficit disorder, learning disorders, and school problems. Am J Hum Genet. 1987;41: 701–741.
20. Conners CK. Symptom patterns in hyperkinetic, neurotic, and normal children. Child Dev. 1970;41: 667–682.
21. Munir K, Biederman J, Knere D. Psychiatric comorbidity in patients with attention deficit disorder: a controlled study. J Am Acad Child Adolesc Psychiatry. 1987;26: 844–848.
22. Sverd J, Curley AD, Jandorf L, Volkersz L. Behavior disorder and attention deficits in boys with Tourette syndrome. J Am Acad Child Adolesc Psychiatry. 1988;27: 413–417.
23. Cohen DJ, Bruun RD, Leckman JF, eds. Tourette's Syndrome and Tic Disorders. New York, NY: John Wiley & Sons Inc; 1988.
24. Comings DE. Tourette Syndrome and Human Behavior. Duarte, Calif: Hope Press; 1990.
25. Kurlan R, ed. Handbook of Tourette's Syndrome and Related Tic and Behavioral Disorders. New York, NY: Marcel Dekker Inc; 1993.
26. Sverd J. Clinical presentations of the Tourette syndrome diatheses. J Multihandicapped Pers. 1989;2: 311–326.
27. Golden GS. Tics and Tourette syndrome. Hosp Pract (Off Ed). 1979;14: 91–93, 96–97, 100.
28. Anderson GM, Pollak ES, Chatterjee D, Leckman JF, Riddle MA, Cohen DJ. Postmortem analysis of subcortical monoamines and amino acids in Tourette syndrome. In: Chase TN, Friedhoff AJ, Cohen DJ, eds. Tourette Syndrome: Genetics, Neurobiology, and Treatment. New York, NY: Raven Press; 1992;58: 123–133.
29. Comings DE. A controlled study of Tourette syndrome, VII: summary: a common genetic disorder causing disinhibition of the limbic system. Am J Hum Genet. 1987;41: 839–866.
30. Comings DE, Comings BG. Tourette's syndrome and attention deficit disorder with hyperactivity: are they genetically related? J Am Acad Child Psychiatry. 1984;23: 138–146.
31. Erenberg G, Cruse RP, Rothner AD. Gilles de la Tourette's syndrome: effects of stimulant drugs. Neurology. 1985;35: 1346–1348.
32. Sverd J, Gadow KD, Paolicelli LM. Methylphenidate treatment of attention-deficit hyperactivity disorder in boys with Tourette's syndrome. J Am Acad Child Adolesc Psychiatry. 1989;28: 574–579.
33. Friedhoff AJ. Receptor maturation in pathogenesis and treatment of Tourette syndrome. In: Friedhoff JA, Chase TN, eds. Gilles de la Tourette Syndrome. New York, NY: Raven Press; 1982;35: 133–140.
34. Price RA, Leckman JF, Pauls DL, Cohen DJ, Kidd KK. Gilles de la Tourette's syndrome: tics and central nervous system stimulants in twins and nontwins. Neurology. 1986;36: 232–237.
35. Waserman J, Lal S, Gauthier S. Gilles de la Tourette's syndrome in monozygotic twins. J Neurol Neurosurg Psychiatry. 1983;46: 75–77.
36. Borcherding BG, Keysor CS, Rapoport JL, Elia J, Amass J. Motor/vocal tics and compulsive behaviors on stimulant drugs: is there a common vulnerability. Psychiatry Res. 1990;33: 83–94.
37. Gadow KD, Nolan EE, Sverd J. Methylphenidate in hyperactive boys with comorbid tic disorder, II: short-term behavioral effects on school settings. J Am Acad Child Adolesc Psychiatry. 1992;31: 462–471.
38. Konkol RJ, Fischer M, Newby RF. Double-blind, placebo-controlled stimulant trial in children with Tourette's syndrome and attention-deficit hyperactivity disorder. Ann Neurol. 1990;28:424. Abstract.
39. Sverd J, Gadow KD, Nolan EE, Sprafkin J, Ezor SN. Methylphenidate in hyperactive boys with comorbid tic disorder, I: clinic evaluations. In: Chase TN, Friedhoff AJ, Cohen DJ, eds. Tourette Syndrome: Genetics, Neurobiology, and Treatment. New York, NY: Raven Press; 1992;58: 271–281.
40. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition. Washington, DC: American Psychiatric Association; 1987.
41. Conners CK. Rating scales for use in drug studies with children. Psychopharmacol Bull. 1973;9(special issue): 24–84.
42. Loney J, Milich R. Hyperactivity, inattention, and aggression in clinical practice. In: Wolraich M, Routh DK, eds. Advances in Developmental and Behavioral Pediatrics. Greenwich, Conn: JAI Press Inc; 1982;3: 113–147.
43. Goyette CH, Conners CK, Ulrich RF. Normative data on revised Conners Parent and Teacher Rating Scales. J Abnorm Child Psychol. 1978;6: 221–236.
44. Loney J. A short parent scale for subgrouping childhood hyperactivity and aggression. Presented at the Annual Meeting of the American Psychological Association; August 1984; Toronto, Ontario.
45. Gadow KD, Sprafkin J. Stony Brook Child Psychiatric Checklist-3R. Stony Brook: Dept of Psychiatry, State University of New York-Stony Brook; 1987.
46. Leckman JF, Riddle MA, Hardin MT, Ort SI, Swartz KL, Stevenson J, Cohen DJ. The Yale Global Tic Severity Scale: initial testing of a clinic-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry. 1989;28: 566–573.
47. Kurlan R, Riddle M, Como P. Tourette Syndrome Unified Rating Scale. Bayside, NY: Tourette Syndrome Association Inc; 1988.
48. Tourette Syndrome Workshop Committee on Classification and Rating Scales. Report of the Tourette Syndrome Workshop on Definitions of Tic Disorders. Bayside, NY; Tourette Syndrome Association Inc; 1988.
49. Kurlan R. Tourette's syndrome: current concepts. Neurology. 1989;39: 1625–1630.
50. Reich W, Welner Z. Diagnostic Interview for Children and Adolescents: Revised Version for Children Ages 6–12 (DSM-III-R Version). Saint Louis, Mo: Division of Child Psychiatry, Washington University; 1988.
51. Reich W, Welner Z. Diagnostic Interview for Children and Adolescents: Revised Parent Version for Children Ages 6–17 (DSM-III-R Version). Saint Louis, Mo: Division of Child Psychiatry, Washington University; 1988.
52. Gadow KD, Paolicelli LM. Global Tic Rating Scale. Stony Brook: Dept of Psychiatry, State University of New York-Stony Brook; 1986.
53. Nolan EE, Gadow KD, Sverd J. Observations and ratings of tics in school settings. J Abnorm Child Psychol. 1994;22: 579–593.
54. Routh DK, Schroeder CS. Standardized playroom measures as indices of hyperactivity. J Abnorm Child Psychol. 1976;4: 199–207.
55. Roberts MA, Ray RS, Roberts RJ. A playroom observational procedure for assessing hyperactive boys. J Pediatr Psychol. 1984;9: 177–191.
56. Milich R, Loney J, Landau S. Independent dimensions of hyperactivity and aggression: a validation with playroom observational data. J Abnorm Psychol. 1982;91: 183–198.
57. Halperin JM, Wolf LE, Pascualvaca DM, Newcorn JH, Healey JM, O'Brien JD, Morganstein A, Young JG. Differential assessment of attention and impulsivity in children. J Am Acad Child Adolesc Psychiatry. 1988;27: 326–329.
58. Halperin JM, Matier K, Bedi G, Sharma V, Newcorn JH. Specificity of inattention, impulsivity, and hyperactivity to the diagnosis of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 1992;31: 190–196.
59. Matier K, Halperin JM, Sharma V, Newcorn JH, Sathaye N. Methylphenidate response in aggressive and non-aggressive ADHD children: distinctions on laboratory measures of symptoms. J Am Acad Child Adolesc Psychiatry. 1992;31: 219–225.
60. Epstein MH, Cullinan D, Gadow KD. Teacher ratings of hyperactivity in learning disabled, emotionally disturbed, and mentally retarded children. J Special Educ. 1986;20: 219–229.
61. Atkins MS, Pelham WE, Licht MH. The differential validity of teacher ratings of inattention/overactivity and aggression. J Abnorm Child Psychol. 1989;17: 423–435.
62. Halperin JM, O'Brien JD, Newcorn JH, Healey JM, Pascualvaca DM, Wolf LE, Young JG. Validation of hyperactive, aggressive, and mixed hyperactive/aggressive childhood disorders: a research note. J Child Psychol Psychiatry. 1990;31: 455–459.
63. Milich R, Fitzgerald G. Validation of inattention/overactivity and aggression ratings with classroom observations. J Consult Clin Psychol. 1985;53: 139–140.
64. Milich R, Landau S. Teacher ratings of inattention/overactivity and aggression: cross validation with classroom observations. J Clin Child Psychol. 1988;17: 92–97.
65. Nolan EE, Gadow KD. Relation between ratings and observations of stimulant drug response in hyperactive children. J Clin Child Psychol. 1994;23: 78–90.
66. Gadow KD. A school-based medication evaluation program. In: Matson JL, ed. Handbook of Hyperactivity in Children. Needham Heights, Mass: Allyn & Bacon; 1993: 186–219.
67. Gadow KD. Peer Conflict Scale. Stony Brook: Dept of Psychiatry, State University of New York-Stony Brook; 1986.
68. Gadow KD. Stimulant Side Effects Checklist. Stony Brook: Dept of Psychiatry, State University of New York-Stony Brook; 1986.
69. Goetz CG, Tanner CM, Wilson RS, Carroll VS, Como PG, Shannon KM. Clonidine and Gilles de la Tourette's syndrome: double-blind study using objective rating methods. Ann Neurol. 1987;21: 307–310.
70. Barkley RA. Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment. New York, NY: Guilford Press; 1990.
71. Gadow KD. Hyperactivity, Learning Disabilities, and Mental Retardation. Austin, Tex: PRO-ED; 1986;1.
72. Werry JS, Sprague RL. Methylphenidate in children: effects of dosage. Aust NZJ Psychiatry. 1974;8: 9–19.
73. Solanto MV. Behavioral effects of low-dose methylphenidate in childhood attention deficit disorder: implications for a mechanism of stimulant drug action. J Am Acad Child Psychiatry. 1986;25: 96–101.
74. Douglas VI, Barr RG, Amin K, O'Neill ME, Britton BG. Dosage effects and individual responsivity to methylphenidate in attention deficit disorder. J Child Psychol Psychiatry. 1988;29: 453–475.
75. Rapport MD, Stoner G, DuPaul GJ, Kelly K, Tucker SB, Schoeler T. Attention deficit disorder and methylphenidate: multilevel analysis of dose-response effects on children's impulsivity across settings. J Am Acad Child Adolesc Psychiatry. 1988;27: 60–69.
76. Gadow KD, Nolan EE, Sverd J, Sprafkin J. School observations of ADHD children with tic disorder: effects of methylphenidate treatment. J Dev Behav Pediatr. Inpress.
77. Chappell PB, McSwiggan-Hardin MT, Scahill L, Rubenstein M, Walker DE, Cohen DJ, Leckman JF. Videotape tic counts in the assessment of Tourette's syndrome: stability, reliability, and validity. J Am Acad Child Adolesc Psychiatry. 1994;33: 386–393.
78. Creager RO, Van Riper C. The effect of methylphenidate on the verbal productivity of children with cerebral dysfunction. J Speech Hear Res. 1967;10: 623–628.
79. Ludlow CL, Rapoport JL, Bassich CJ, Mikkelson EG. Differential effects of dextroamphetamine on language performance of hyperactive and normal boys. In: Knights RM, Bakker DJ, eds. Treatment of Hyperactive and Learning Disordered Children. Baltimore, Md: University Park Press; 1980: 185–205.
80. Barkley RA, Cunningham CE, Karlsson J. The speech of hyperactive children and their mothers: comparison with normal children and stimulant drug effects. J Learning Disabilities. 1983;16: 105–110.
81. Whalen CK, Collins BE, Henker B, Alkus SR, Adams D, Stapp J. Behavior observations of hyperactive children and methylphenidate (Ritalin) effects in systematically structured classroom environments: now you see them, now you don'st. J Pediatr Psychol. 1978;3: 177–187.
82. Sprafkin J, Gadow KD. Four purported cases of methylphenidate-induced tic exacerbation: methodological and clinical doubts. J Child Adolesc Psychopharmacol. 1993;3: 231–244.
83. Gadow KD. Pediatric psychopharmacotherapy: a review of recent research. J Child Psychol Psychiatry. 1992;33: 153–195.
84. Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trends Neurosci. 1989;12: 366–375.
85. Young AB, Penney JB. Biochemical and functional organization of the basal ganglia. In: Jankovic J, Tolosa E, eds. Parkinson's Disease and Movement Disorders. Baltimore, Md: Urban & Schwarzenberg; 1988: 1–11.
86. Haber SN, Wolfer D. Basal ganglia peptidergic staining in Tourette syndrome: a follow-up study. In: Chase TN, Friedhoff AJ, Cohen DJ, eds. Tourette Syndrome: Genetics, Neurobiology, and Treatment. New York, NY: Raven Press; 1992;58: 145–150.
87. McConville BJ, Norman AB, Vogelson MH, Erenberg G. Sequential use of opioid antagonists and agonists in Tourette's syndrome. Lancet. 1994;343:601.