Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: differentiation from progressive supranuclear palsy

Acta Neuropathologica

Volumn 90, Issue 1, 1995, Pages 37-43

  Feany, M B ^a   Ksiezak Reding, H ^a   Liu, W K ^a   Vincent, I ^a   Yen, S H C ^a   Dickson, D W ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Astrocytic plaques; Corticobasal degeneration; Oligodendroglial inclusions; Phosphorylation; Tau protein

Indexed keywords

ANTIBODY; EPITOPE; PHOSPHATASE; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; BIOACCUMULATION; CELL INCLUSION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORTICOBASAL DEGENERATION; CYTOSKELETON; EXON; FEMALE; GLIA CELL; GRAY MATTER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL; NEUROLOGIC DISEASE; OLIGODENDROGLIA; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; PROTEIN PHOSPHORYLATION; WHITE MATTER;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIBODIES; EPITOPES; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGE; NERVE DEGENERATION; PHOSPHORYLATION; TAU PROTEINS;

EID: 0029041149     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/BF00294457     Document Type: Article

References (40)

1. Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences
2. The switch of tau protein to an Alzhemier-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region
3. The distribution of tau polypeptides in the mammalian central nervous system
4. Clinical and pathological study of two patients with progressive supranuclear palsy and Alzheimer's changes. Antigenic determinants that distinguish cortical and subcortical neurofibrillary tangles
5. Immunocytochemical studies distinguish corticobasal degeneration from progressive supranuclear palsy (abstract)
6. Pick body-like inclusions in the dentate fascia of the hippocampus in Alzheimer's disease
7. Immunocytochemistry of neurofibrillary tangles with antibodies to subregions of tau protein: identification of hidden and cleaved tau epitopes and a new phosphorylation site
8. Phosphorylated tau immunoreactivity of granulovacuolar bodies (GVB) of Alzheimer's disease: localization of two amino-terminal tau epitopes in GVB
9. Tau protein function in living cells
10. Abnormal tau proteins in progressive supranuclear palsy
11. Corticobasal degeneration
12. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease
13. Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms
14. A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis
15. Neuronal and glial tau-positive inclusions in diverse neurologic disease share common phosphorylation characteristics
16. Diagnosis of Alzheimer's disease
17. Microtubule-associated protein tau (τ) is a major antigenic component of paired helical filaments in Alzheimer's disease
18. Epitopes that span the tau molecule are shared with paired helical filaments
19. Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration
20. Cortico-basal ganglionic degeneration
21. Dementia with pathological findings of cortical-basal degeneration (abstract)
22. Corticonigral degeneration with neuronal achromasia. A clinicopathological study of two cases
23. Abnormal tau proteins from Alzheimer's disease brains: purification and amino acid analysis
24. Heterogeneity of tau protein in Alzheimer's disease
25. Amino acid residues 226–240 of τ, which encompass the first Lys-Ser-Pro site of τ, are partially phosphorylated in Alzheimer paired helical filament-τ
26. Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
27. A new neuritic plaque without amyloid in corticonigral degeneration with neuronal achromasia (abstract)
28. Corticobasal degeneration: a disease with widespread appearance of abnormal tau and neurofibrillary tangles, and its relation to progressive supranuclear palsy
29. Corticonigral degeneration with neuronal achromasia and basal neurofibrillary tangles
30. Progressive supranuclear palsy: extensive neuropil threads in addition to neurofibrillary tangles
31. Corticodentatonigral degeneration with neuronal achromasia: a progressive disorder of late adult life
32. Corticodentatonigral degeneration with neuronal achromasia
33. Electron microscopic study of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome
34. Properties of antigenic determinants that distinguish neurofibrillary tangles in progressive supranuclear palsy and Alzheimer's disease
35. Ultrastructure of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome
36. Corticobasal degeneration: etiopathological significance of the cytoskeletal alterations
37. A neuronal antigen in the brain of Alzheimer patients
38. Monoclonal antibodies to Alzheimer neurofibrillary tangles. I. Identification of polypeptides