A prospective study of treatment of acquired (autoimmune) factor VIII inhibitors with high-dose intravenous gammaglobulin

Blood

Volumn 86, Issue 2, 1995, Pages 797-804

  Schwartz, Richard S ^b   Gabriel, Don A ^b   Aledort, Louis M ^b   Green, David ^b   Kessler, Craig M ^b  

^a BAYER AG   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 ANTIBODY; BLOOD CLOTTING FACTOR 8 INHIBITOR; CYCLOPHOSPHAMIDE; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; PREDNISONE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CRYOPRECIPITATE; DRUG EFFICACY; DRUG MEGADOSE; ERYTHROCYTE TRANSFUSION; FEMALE; HEADACHE; HEMOPHILIA; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; MULTICENTER STUDY; PLASMAPHERESIS; PRIORITY JOURNAL; PRURITUS; VERTIGO; WHEEZING;

EID: 0029040859     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v86.2.797.bloodjournal862797     Document Type: Article

References (31)

1. Shapiro SS, Hultin M: Acquired inhibitors to the blood coagulation factors. Semin Thromb Hemost 1:336, 1975
2. Green D, Lechner K: A survey of 215 non-hemophilic patients with inhibitors to F VIII. Thromb Haemost 45:200, 1981
3. Hultin MB: Acquired inhibitors in malignant and nonmalignant disease states. Am J Med 91:9S, 1991 (suppl 5A)
4. Kessler CM: An introduction to factor VIII inhibitors: The detection and quantitation. Am J Med 91:1S, 1991 (suppl 5A)
5. Spero JA, Lewis JH, Hasiba U: Corticosteroid therapy for acquired factor VIII:C inhibitors. Br J Haematol 48:635, 1981
6. Green D: Cytotoxic suppression of acquired factor VIII:C inhibitors. Am J Med 91:14S, 1991 (suppl 5A)
7. Green D: Immunosuppression of factor VIII inhibitors in non-hemophilic patients. Semin Hematol 30:28, 1993 (suppl 1)
8. Lusher JM: Perspective on the use of factor IX complex concentrates in the treatment of bleeding in persons with acquired factor VIII inhibition. Am J Med 91:30S, 1991 (suppl 5A)
9. Morrison AE, Lundlam CA: The use of porcine factor VIII in the treatment of patients with acquired haemophilia: The United Kingdom Experience. Am J Med 91:23S, 1991 (suppl 5A)
10. Imbach P, Barandun S, d'Apuzzo V, Baumgartner C, Hirt A, Morell A, Rossi E, Schöni M, Vest M, Wagner HP: High dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet 1:1228, 1981
11. Schmidt RE, Budde U, Schäfer G, Stroehmann I: High dose intravenous immunoglobulin for idiopathic thrombocytopenic purpura. Lancet 2:475, 1981 (letter)
12. Bussel JB, Hilgartner MW: The use and mechanism of action of intravenous immunoglobulin in the treatment of immune haematologic disease. Br J Haematol 56:1, 1984
13. Pollack S, Cunningham-Rundles C, Smithwick EM, Barandun S, Good RA: High dose intravenous gammaglobulin for autoimmune neutropenia. N Engl J Med 307:243, 1982
14. Gajdos Ph, Outin H, Elkarrat D, Brunei D, De Rohan-Chabot P, Raphael JC, Goulon M, Goulon-Goeau C, Morel E: High dose intravenous immunoglobulin for myasthenia gravis. Lancet 1:406, 1984 (letter)
15. Sultan Y, Kazatchkine MD, Maisonneuve P, Nydegger UE: Anti-idiotypic suppression of autoantibodies to factor VIII (antihaemophilic factor) by high-dose intravenous gammaglobulin. Lancet 2:765, 1984
16. Zimmermann R, Kommerell B, Harenberg J, Eich W, Rother K, Schimpf KL: Intravenous IgG for patients with spontaneous inhibitor to factor VIII. Lancet 1:273, 1985
17. Hiller E, Holler E, Geursen RG, Riess H: Successful treatment with high-dose intravenous immunoglobulin in a patient with spontaneous inhibitor to factor VIII. Blut 52:123, 1986
18. Newland Ac, Macey MG, Moffat EH, Ainsworth M, Colvin BT: Effect of intravenous immunoglobulin on a spontaneous inhibitor to factor VIII. Clin Lab Haematol 10:435, 1988
19. Green D, Kwaan HC: An acquired factor VIII inhibitor responsive to high dose gammaglobulin. Thromb Haemost 58:1005, 1987
20. Carreras LO, Perez GN, Xavier DI, Blanco AN, Penalva LB: Autoimmune factor VIIII inhibitor responsive to gammaglobulin without in vitro neutralization. Thromb Haemost 60:343, 1988
21. Heyman MP, Chakravathy A, Edelman BB, Needleman SW, Schiffer CA: Failure of high dose IV gammaglobulin in the treatment of spontaneously acquired factor VIII inhibitors. Am J Hematol 28:191, 1988
22. Schwartz RS: Overview of the biochemistry and safety of a new native intravenous gamma globulin, IGIV, pH 4.25. Am J Med 83:46, 1987 (suppl 4A)
23. Kasper CK, Aledort LM, Counts RB, Edson JR, Fratantoni J, Green D, Hampton JW, Hilgartner MW, Lazerson J, Levine PH, McMillan CW, Pool JG, Shapiro SS, Shulman NR, Van Eys J: A more uniform measurement of factor VIII inhibitors. Thromb Diath Haemorrh 34:869, 1975
24. Sultan Y, Kazatchkine MD, Nydegger U, Rossi F, Dietrich G, Algiman M: Intravenous immunoglobulin in the treatment of spontaneously acquired factor VIII:C inhibitors. Am J Med 91:35S, 1991 (suppl 5A)
25. Fehr J, Hoffman V, Kappeler U: Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high-dose intravenous gammaglobulin. N Engl J Med 306:1254, 1982
26. Salama A, Mueller-Eckhardt C, Kiefel V: Effect of intravenous immunoglobulin in immune thrombocytopenia. Competitive inhibition of reticuloendothelial system function by sequestration of autologous red blood cells? Lancet 2:193, 1983
27. Delfraissy JF, Tchernia G, Laurian Y, Wallon C, Galanaud P, Dormont J: Suppressor cell function after intravenous gamma-globulin treatment in adult chronic idiopathic thrombocytopenic purpura. Br J Haematol 60:315, 1985
28. Dammacco F, Iodice G, Campobasso N: Treatment of adult patients with idiopathic thrombocytopenic purpura with intravenous immunoglobulin: Effects on circulating T cell subsets and PWM-induced antibody synthesis in vitro. Br J Haematol 62:125, 1986
29. Rossi F, Sultan Y, Kazatchkine MD: Anti-idiotypes against autoantibodies and alloantibodies to factor VIIIc (anti-hemophilic factor) are present in therapeutic polyspecific normal immunoglobulins. Clin Exp Immunol 74:311, 1988
30. Sultan Y, Rossi F, Kazatchkine MD: Recovery from anti-VIIII:C (antihemophilic factor) autoimmune disease is dependent on generation of anti-idiotypes against anti VIII:C autoantibodies. Proc Natl Acad Sci USA 84:828, 1987
31. Dietrich G, Algiman M, Sultan Y, Nydegger UE, Kazatchkine MD: Origin of anti-idiotypic activity against anti-factor VIIII autoantibodies in pools of normal human immunoglobulin G (IVIg). Blood 11:2946, 1992