Systemic administration of rIL-12 induces complete tumor regression and protective immunity: Response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells

International Immunology

Volumn 7, Issue 7, 1995, Pages 1135-1145

  Zou, Jian ping ^a   Yamamoto, Norihiko ^a   Fujii, Tetsuya ^a   Takenaka, Hiroshi ^a   Kobayashi, Michiko ^a,b   Herrmann, Steven H ^a,b   Wolf, Stanley F ^a,b   Fujiwara, Hiromi ^c   Hamaoka, Toshiyuki ^c  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b PFIZER INC   (United States)

^c NONE

Author keywords

IFN ; IL 12; Immunosuppression; Immunotherapy; Tumor

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER IMMUNOTHERAPY; CANCER TRANSPLANTATION; EXPERIMENTAL NEOPLASM; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; TUMOR IMMUNITY; TUMOR REGRESSION;

ANIMAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FIBROSARCOMA; IMMUNE TOLERANCE; IMMUNITY, NATURAL; IMMUNOPHENOTYPING; INJECTIONS, INTRAPERITONEAL; INTERFERON TYPE II; INTERLEUKIN-12; LYMPHOKINES; MALE; MICE; MICE, INBRED BALB C; RECOMBINANT PROTEINS; REMISSION INDUCTION; SPLEEN; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0029039610     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/7.7.1135     Document Type: Article

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