The development of morphine tolerance and dependence is associated with translocation of protein kinase C

Pain

Volumn 61, Issue 3, 1995, Pages 365-374

  Mayer, David J ^a   Mao, Jianren ^a   Price, Donald D ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Analgesia; Dependence; GMI ganglioside; Morphine; Narcotic analgesic; Protein kinase C; Tolerance; 3H Phorbol 12,13 dibutyrate

Indexed keywords

GANGLIOSIDE GM1; MORPHINE; PROTEIN KINASE C;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DEPENDENCE; DRUG TOLERANCE; INTRAPERITONEAL DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; MALE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SPINAL CORD;

ANIMAL; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CYTOSOL; DRUG THERAPY, COMBINATION; DRUG TOLERANCE; G(M1) GANGLIOSIDE; INJECTIONS, SPINAL; MALE; MORPHINE; MORPHINE DEPENDENCE; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029039560     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3959(95)00023-L     Document Type: Article

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