Chondrocyte deformation and local tissue strain in articular cartilage: A confocal microscopy study

Journal of Orthopaedic Research

Volumn 13, Issue 3, 1995, Pages 410-421

  Guilak, Farshid ^a   Ratcliffe, Anthony ^b   Mow, Van C ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BIOMECHANICS; BONE STRESS; CARTILAGE CELL; CARTILAGE DEGENERATION; COMPRESSION; CONTROLLED STUDY; DOG; EXTRACELLULAR MATRIX; MORPHOMETRICS; NONHUMAN; PHYSICAL STRESS; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION;

ANIMAL; CARTILAGE, ARTICULAR; DOGS; EXTRACELLULAR MATRIX; MEDICAL ILLUSTRATION; MICROSCOPY, CONFOCAL; PRESSURE; STRESS, MECHANICAL; SUPPORT, NON-U.S. GOV'T;

EID: 0029039386     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.1100130315     Document Type: Article

References (56)

1. Tensile properties of knee joint cartilage. I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus
2. Changes in the deformational behavior of human hip cartilage with age
3. Differences between sub‐populations of cultured bovine articular chondrocytes. II. Proteoglycan metabolism
4. Structure of proteoglycans from different layers of human articular cartilage
5. Animal cell shape changes and gene expression
6. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels
7. The role of calcium in the inhibition of cAMP accumulation in epiphyseal cartilage cells exposed to physiological pressure
8. Three‐dimensional confocal fluorescence microscopy
9. A study of the structural response of wet hyaline cartilage to various loading situations
10. The effective elastic moduli of composite materials containing spherical inclusions at non‐dilute concentrations
11. The organization of collagen in cryofractured rabbit articular cartilage: a scanning electron microscopic study
12. Quantitation of structural features characterizing weight‐ and less‐weight‐bearing regions in articular cartilage: a stereological analysis of medial femoral condyles in young adult rabbits
13. Activation of ion transport systems during cell volume regulation
14. Role of cell shape in growth control
15. Cartilage electromechanics—I. Electrokinetic transduction and the effects of electrolyte pH and ionic strength
16. Chondrocytes respond to mechanical loading by maintaining a constant aspect ratio
17. Compliance of articular cartilage and its variation through the thickness
18. Mechanical and physiocochemical determinants of the chondrocyte biosynthetic response
19. Transport of fluid and ions through a porous‐permeable charged‐hydrated tissue, and streaming potential data on normal bovine articular cartilage
20. Determination of the mechanical response of the chondrocyte in situ using confocal microscopy and finite element analysis
21. Volume and surface area measurement of viable chondrocytes in situ using geometric modeling of serial confocal sections
22. Intracellular and intercellular propagation of deformation‐induced calcium transients in articular chondrocytes
23. Deformation‐induced calcium signalling in articular chondrocytes
24. The effects of hydrostatic pressure on matrix synthesis in articular cartilage
25. Flow‐independent viscoelastic properties of articular cartilage matrix
26. Properties of red blood cells
27. Integrins as mechanochemical transducers
28. The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans
29. Mechanical properties of articular cartilage
30. PolyPaint—a three‐dimensional rendering package
31. A triphasic theory for the swelling and deformation behaviors of articular cartilage
32. Physicochemical properties of articular cartilage
33. Calcium signaling in cell volume regulation
34. Mechanosensitive ion channels
35. Fluid transport and mechanical properties of articular cartilage: a review
36. Influence of cytochalasin D‐induced changes in cell shape on proteoglycan synthesis by cultured articular chondrocytes
37. Differential response to compressive loads of zones of canine hyaline articular cartilage: micromechanical, light and electron microscopic studies
38. Fundamental limits in confocal microscopy
39. Chondrons extracted from canine tibial cartilage: preliminary report on their isolation and structure
40. Mechanical transduction by membrane ion channels: a mini review
41. Biosynthetic response of cartilage explants to dynamic compression
42. Activation of ion transport pathways by changes in cell volume
43. Articular cartilage morphology
44. Video microscopy to quantitate the inhomogeneous strain within articular cartilage during confined compression
45. Pre‐stress in articular cartilage due to internal swelling pressure
46. Effects of friction on the unconfined compressive response of articular cartilage: a finite element analysis
47. The chondrocytes
48. Structure and function of the chondrocyte under mechanical stress
49. Joint induced alteration in articular cartilage
50. Regulation of matrix synthesis rates by the ionic and osmotic environment of articular chondrocytes
51. Cartilage and chondrocytes responses to mechanical loading in vitro
52. Function follows form: generation of intracellular signals by cell deformation
53. Measurements of non‐homogeneous, directional mechanical properties of articular cartilage in tension
54. Two subpopulations of differentiated chondrocytes identified with a monoclonal antibody to keratan sulfate