Positive selection of T cells

Current Opinion in Immunology

Volumn 7, Issue 2, 1995, Pages 188-195

  Fowlkes, BJ ^a   Schweighoffer, Edina ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

CELL DIFFERENTIATION; CELL LINEAGE; CELL SELECTION; MAJOR HISTOCOMPATIBILITY COMPLEX; PROLYMPHOCYTE; REVIEW; T LYMPHOCYTE; THYMOCYTE;

ANIMAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; RECEPTORS, ANTIGEN, T-CELL;

EID: 0029038175     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/0952-7915(95)80003-4     Document Type: Article

References (54)

1. Positive selection of lymphocytes
2. Analysis and expression of a cloned pre-T cell receptor gene
3. T-cell receptor-β chain gene rearrangement and selection during thymocyte development in adult mice
4. Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon
5. CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo
6. An activated lck transgene promotes thymocyte development in Rag-1 mutant mice
7. Selective events in T cell development
8. Thymic epithelial cell lines that mediate positive selection can also induce thymocyte clonal deletion
9. A thymic epithelial cell line induces both positive and negative selection in the thymus
10. Characteristics of an in vitro system of thymocyte positive selection
11. +- thymocytes in vitro
12. + thymic epithelial cells in vitro costimulatory signals mediated by B7 are not involved
13. A positively selecting thymic epithelial cell ??? stimulatory activity
14. A subset of CD4+ thymocytes selected by MHC class I molecules
15. − NK1.1+ thymocytes
16. − T cells in mice and humans
17. The ligand for positive selection of T lymphocytes in the thymus
18. Peptides in positive and negative selection: a delicate balance
19. Thymic selection: two pathways to life and two to death
20. Evidence for a differential avidity model of T cell selection in the thymus
21. Positive and negative thymocyte selection induced by different concentrations of a single peptide
22. T cell receptor antagonist peptides induce positive selection
23. Specificity and flexibility in thymic selection
24. A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes
25. + thymocytes by T-cell receptor peptide antagonists
26. Commitment to CD4 and CD8 lineages — stochastic or instructive?
27. Stochastic component to development of class I major histocompatibility complex-specific T cells
28. Functional commitment to helper T-cell lineage precedes positive selection and is independent of T-cell receptor MHC specificity
29. + helper T cells in class II major histocompatibility complex mutant mice
30. Role of coreceptors in positive selection and lineage commitment
31. Thymic development in human CD4 transgenic mice — positive selection occurs after commitment to the CD8 lineage
32. Another view of the selective model of thymocyte selection
33. Regulation of RAG-1 and CD69 expression in the thymus during positive and negative selection
34. low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules
35. Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice
36. Helper T cells without CD4; control of leishmaniasis in CD4-deficient mice
37. + T cells by TCR ligation without aggregation even in the absence of MHC
38. + single positive cells with a class II major histocompatibility complex-restricted receptor
39. Small cortical thymocytes are subject to positive selection
40. low thymocytes contain precursors of mature T cells
41. Production, selection, and maturation of thymocytes with high surface density of TCR
42. CD4 or CD8 down-regulation occurs at different stages of thymocyte differentiation
43. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
44. A transcriptional silencer controls the developmental expression of the CD4 gene
45. Signal transduction by lymphocyte antigen receptors
46. + thymic selection in humans lacking ZAP-70 kinase
47. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
48. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodefficiency
49. + thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus
50. + stage during positive selection and promotes thymocyte differentiation at several control points
51. Requirement for CD8β chain in positive selection of CD8-lineage T cells
52. Disruption of T-lymphocyte positive and negative selection in mice lacking the CD8β chain
53. + T cells in CD8β gene-targeted mice
54. A role for the cytoplasmic tail of the β-chain of CD8 in thymic selection