-
1
-
-
0023946636
-
Studies Directed toward Ascertaining the Active Conformation of 1, 4-Dihdyropyridine Calcium Entry Blockers
-
Rovnyak, G.; Andersen, N.; Gougoutas, J.; Hedberg, A.; Kimball, S. D.; Malley, M.; Moreland, S.; Porubcan, M.; Pudzianowski, A. Studies Directed toward Ascertaining the Active Conformation of 1, 4-Dihdyropyridine Calcium Entry Blockers. J. Med. Chem. 1988, 31, 936.
-
(1988)
J. Med. Chem.
, vol.31
, pp. 936
-
-
Rovnyak, G.1
Andersen, N.2
Gougoutas, J.3
Hedberg, A.4
Kimball, S.D.5
Malley, M.6
Moreland, S.7
Porubcan, M.8
Pudzianowski, A.9
-
2
-
-
0026095516
-
Active Conformation of 1, 4-Dihydropyridine Calcium Entry Blockers. Effect of Size of 2-Aryl Substituent on Rotamene Equilibria and Receptor Binding
-
Rovnyak, G.; Andersen, N.; Gougoutas, J.; Hedberg, A.; Kimball, S. D.; Malley, M.; Moreland, S.; Porubcan, M.; Pudzianowski, A. Active Conformation of 1, 4-Dihydropyridine Calcium Entry Blockers. Effect of Size of 2-Aryl Substituent on Rotamene Equilibria and Receptor Binding. J. Med. Chem. 1991, 34, 2521.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 2521
-
-
Rovnyak, G.1
Andersen, N.2
Gougoutas, J.3
Hedberg, A.4
Kimball, S.D.5
Malley, M.6
Moreland, S.7
Porubcan, M.8
Pudzianowski, A.9
-
3
-
-
85022770389
-
-
Abstracts of Papers, American Chemical Society: Washington, DC
-
Seidel, W.; Meyer, H.; Bom, L.; Kasda, S.; Dompert, W. Abstracts of Papers, Division of Medicinal Chemistry; 187th National Meeting of the American Chemical Society, St. Louis, MO, April 8-13; American Chemical Society: Washington, DC, 1984.
-
(1984)
Division of Medicinal Chemistry; 187th National Meeting of the American Chemical Society, St. Louis, MO, April 8-13
-
-
Seidel, W.1
Meyer, H.2
Bom, L.3
Kasda, S.4
Dompert, W.5
-
4
-
-
0142202805
-
Rigid Calcium Antagonists of the Nifedipine-type: Geometric Requirements for the Dihydropyridine Receptor
-
5th, [54QWAZ]
-
Seidel, W.; Meyer, H.; Bom, L.; Kasda, S.; Dompert, W. Rigid Calcium Antagonists of the Nifedipine-type: Geometric Requirements for the Dihydropyridine Receptor. Proc. Eur. Symp. Quant. Struct.-Act. Relat. 1984, 5th, [54QWAZ], 366-399.
-
(1984)
Proc. Eur. Symp. Quant. Struct.-Act. Relat.
, pp. 366-399
-
-
Seidel, W.1
Meyer, H.2
Bom, L.3
Kasda, S.4
Dompert, W.5
-
5
-
-
85022820059
-
Novel Rigid Calcium Entry Blockers: Intramolecular Reactions of 1, 4-Dihydropyridine Derivatives
-
Abstracts of Papers, American Chemical Society: Washington, DC
-
Claremon, D. A.; Lumma, P. K. Novel Rigid Calcium Entry Blockers: Intramolecular Reactions of 1, 4-Dihydropyridine Derivatives. Abstracts of Papers, Division of Medicinal Chemistry; 187th National Meeting of the American Chemical Society, St. Louis, MO, April 8-13; American Chemical Society: Washington, DC, 1984.
-
(1984)
Division of Medicinal Chemistry; 187th National Meeting of the American Chemical Society, St. Louis, MO, April 8-13
-
-
Claremon, D.A.1
Lumma, P.K.2
-
6
-
-
0023192126
-
Diethyl 3, 6-Dihydro-2, 4-dimethyl-2, 6-methano-l, 3-benzothiazine 5, 11-dicar-boxylates as Calcium Entry Antagonists: New Conformationally Restrained Analogues of Hantzsch 1, 4-Dihydropyridines Related to Nitendipine as Probes for Receptor-Site Conformation
-
Baldwin, J. J.; Claremon, D. A.; Lumma, P. K.; McClure, D. E.; Rosenthal, S. A.; Winquist, R. J.; Faison, E. P.; Kaczorowski, G. J.; Trumble, M. J.; Smith, G. M. Diethyl 3, 6-Dihydro-2, 4-dimethyl-2, 6-methano-l, 3-benzothiazine 5, 11-dicar-boxylates as Calcium Entry Antagonists: New Conformationally Restrained Analogues of Hantzsch 1, 4-Dihydropyridines Related to Nitendipine as Probes for Receptor-Site Conformation. J. Med. Chem. 1987, 30, 690.
-
(1987)
J. Med. Chem.
, vol.30
, pp. 690
-
-
Baldwin, J.J.1
Claremon, D.A.2
Lumma, P.K.3
McClure, D.E.4
Rosenthal, S.A.5
Winquist, R.J.6
Faison, E.P.7
Kaczorowski, G.J.8
Trumble, M.J.9
Smith, G.M.10
-
7
-
-
0026342780
-
1, 4-Dihydropyridines: Effect of Chirality and Conformation of the Calcium Antagonist and Calcium Agonist Activities
-
and references therein
-
Goldmann, S.; Stolteftiss, J. 1, 4-Dihydropyridines: Effect of Chirality and Conformation of the Calcium Antagonist and Calcium Agonist Activities. Angew. Chem., Int. Ed. Engl. 1991, 30, 1559 and references therein.
-
(1991)
Angew. Chem., Int. Ed. Engl.
, vol.30
, pp. 1559
-
-
Goldmann, S.1
Stolteftiss, J.2
-
8
-
-
0024477866
-
Calcium Channel Ligands: Structure-Function Relationships of the 1, 4-Dihydropyridines
-
Triggle, D. J.; Langs, D. A.; Janis, R. A. Calcium Channel Ligands: Structure-Function Relationships of the 1, 4-Dihydropyridines. Med. Res. Rev. 1989, 9, 123.
-
(1989)
Med. Res. Rev.
, vol.9
, pp. 123
-
-
Triggle, D.J.1
Langs, D.A.2
Janis, R.A.3
-
9
-
-
0020579260
-
Activation of Calcium Channels by Novel Dihydropyridines: A new Mechanism for Positive Inotropic Agents
-
Schramm, M.; Thomas, G.; Towart, R.; Franckowiak, G. Activation of Calcium Channels by Novel Dihydropyridines: A new Mechanism for Positive Inotropic Agents. Nature 1983, 303, 535.
-
(1983)
Nature
, vol.303
, pp. 535
-
-
Schramm, M.1
Thomas, G.2
Towart, R.3
Franckowiak, G.4
-
10
-
-
85022790218
-
New 1, 4-Dihydropyridines with Calcium-Agonist Effects
-
Goldmann, S.; Bossert, F.; Schramm, M.; Thomas, G. New 1, 4-Dihydropyridines with Calcium-Agonist Effects. Proc. Vllth Int. Symp. Med. Chem. Upsala 1984, 1, 318.
-
(1984)
Proc. Vllth Int. Symp. Med. Chem. Upsala
, vol.1
, pp. 318
-
-
Goldmann, S.1
Bossert, F.2
Schramm, M.3
Thomas, G.4
-
11
-
-
0021355075
-
Enhancement of Calcium Influx in Human Platelets by CGP 28392, A Novel Dihydropyridine
-
Erne, P.; Burgisser, E.; Buhler, F. R.; Dubach, B.; Kuhnis, H.; Merier, M.; Rogg. Enhancement of Calcium Influx in Human Platelets by CGP 28392, A Novel Dihydropyridine. Biochem. Biophys. Res. Commun. 1984, 118, 842.
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.118
, pp. 842
-
-
Erne, P.1
Burgisser, E.2
Buhler, F.R.3
Dubach, B.4
Kuhnis, H.5
Merier, M.6
Rogg7
-
12
-
-
0023326212
-
A Molecular Graphics Study on Structure-action Relationships of Calcium-antagonistic and Agonistic 1, 4-Dihydropyridines
-
Holtje, H. D.; Marrer, S. A Molecular Graphics Study on Structure-action Relationships of Calcium-antagonistic and Agonistic 1, 4-Dihydropyridines. J. Comput.-Aided Mol. Des. 1987, 1, 20.
-
(1987)
J. Comput.-Aided Mol. Des.
, vol.1
, pp. 20
-
-
Holtje, H.D.1
Marrer, S.2
-
13
-
-
0026147787
-
Molecular Level Model for the Agonist/Antagonist Selectivity of the 1, 4-Dihydropyridine Calcium Channel Receptor
-
and references therein
-
Langs, D. A.; Kwon, Y. W.; Strong, P. D.; Triggle, D. J. Molecular Level Model for the Agonist/Antagonist Selectivity of the 1, 4-Dihydropyridine Calcium Channel Receptor. J. Comput.-Aided Mol. Des. 1991, 5, 95 and references therein.
-
(1991)
J. Comput.-Aided Mol. Des.
, vol.5
, pp. 95
-
-
Langs, D.A.1
Kwon, Y.W.2
Strong, P.D.3
Triggle, D.J.4
-
14
-
-
0026510187
-
Pharmacologic and Radioligand Binding Studies of 1, 4-Dihydropyridines in Rat Cardiac and Vascular Preparations: Stereoselectivity and Voltage Dependence of Antagonist and Activator Interactions
-
and references therein
-
Zheng, W.; Stoltefuss, J.; Goldmann, S.; Triggle, D. J. Pharmacologic and Radioligand Binding Studies of 1, 4-Dihydropyridines in Rat Cardiac and Vascular Preparations: Stereoselectivity and Voltage Dependence of Antagonist and Activator Interactions. Mol. Pharmacol. 1992, 41, 535 and references therein.
-
(1992)
Mol. Pharmacol.
, vol.41
, pp. 535
-
-
Zheng, W.1
Stoltefuss, J.2
Goldmann, S.3
Triggle, D.J.4
-
15
-
-
0026648194
-
Molecular Modeling Studies on 1, 4-Dihydropγ-ridines Acting at the Ca-Channel
-
Holtje, H.-D. Molecular Modeling Studies on 1, 4-Dihydropγ-ridines Acting at the Ca-Channel. Quant. Struct.-Act. Relat. 1992, 11, 224.
-
(1992)
Quant. Struct.-Act. Relat.
, vol.11
, pp. 224
-
-
Holtje, H.-D.1
-
16
-
-
0027260683
-
The molecular Mode of Action of the Calcium Agonist Levo Bay K 8644 on the Cardiac Calcium Channel
-
Bechern, M.; Hoffmann, H. The molecular Mode of Action of the Calcium Agonist Levo Bay K 8644 on the Cardiac Calcium Channel. Pfluegers Arch. 1993, 424, 343.
-
(1993)
Pfluegers Arch.
, vol.424
, pp. 343
-
-
Bechern, M.1
Hoffmann, H.2
-
17
-
-
0025274376
-
Dihydropyrimidine Calcium Channel Blockers: 2-Heterosubstituted 4-Aryl-l, 4- dihydro-6-methyl-5-pyrimidinecarboxylic Acid esters as Potent Mimics of Dihydropyrimidines
-
Atwal, K.; Rovnyak, G. C.; Schwartz, J.; Moreland, S.; Hedberg, A.; Gougoutas, J.; Malley, M.; Floyd, D. Dihydropyrimidine Calcium Channel Blockers: 2-Heterosubstituted 4-Aryl-l, 4- dihydro-6-methyl-5-pyrimidinecarboxylic Acid esters as Potent Mimics of Dihydropyrimidines. J. Med. Chem. 1990, 33, 1510.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 1510
-
-
Atwal, K.1
Rovnyak, G.C.2
Schwartz, J.3
Moreland, S.4
Hedberg, A.5
Gougoutas, J.6
Malley, M.7
Floyd, D.8
-
18
-
-
0024427853
-
Dihydropyrimidines: Novel Calcium Antagonists with Potent and Long-Lasting Vasodilative and Antihypertensive Activity
-
Cho, H.; Ueda, M.; Shima, K.; Mizuno, A.; Hayashimatsu, M.; Ohnaka, Y.; Takeuchi, Y.; Hamaguchi, M.; Aisaka, K.; Hidaka, T.; Kawai, M.; Takeda, M.; Ishihara, T.; Funahashi, K.; Satoh, F.; Morita, M.; Noguchi, T. Dihydropyrimidines: Novel Calcium Antagonists with Potent and Long-Lasting Vasodilative and Antihypertensive Activity. J. Med. Chem. 1989, 32, 2399.
-
(1989)
J. Med. Chem.
, vol.32
, pp. 2399
-
-
Cho, H.1
Ueda, M.2
Shima, K.3
Mizuno, A.4
Hayashimatsu, M.5
Ohnaka, Y.6
Takeuchi, Y.7
Hamaguchi, M.8
Aisaka, K.9
Hidaka, T.10
Kawai, M.11
Takeda, M.12
Ishihara, T.13
Funahashi, K.14
Satoh, F.15
Morita, M.16
Noguchi, T.17
-
19
-
-
0001359144
-
An Improved Synthesis of Pilocarpine
-
DeGraw, J. I. An Improved Synthesis of Pilocarpine. Tetrahedron 1972, 28, 967.
-
(1972)
Tetrahedron
, vol.28
, pp. 967
-
-
DeGraw, J.I.1
-
21
-
-
0023916232
-
Pressor responses induced by Bay K 8644 involve both release of adrenal catecholamines and calcium channel activation
-
Moreland, S.; Ushay, M. P.; Kimball, S. D.; Powell, J. R.; Moreland, R. S. Pressor responses induced by Bay K 8644 involve both release of adrenal catecholamines and calcium channel activation. Br. J. Pharmacol. 1988, 93, 994.
-
(1988)
Br. J. Pharmacol.
, vol.93
, pp. 994
-
-
Moreland, S.1
Ushay, M.P.2
Kimball, S.D.3
Powell, J.R.4
Moreland, R.S.5
-
22
-
-
0023212340
-
Effects of dihydropyridines on stress, myosin phosphorylation, and V„ in smooth muscle
-
Moreland, S.; Moreland, R. S. Effects of dihydropyridines on stress, myosin phosphorylation, and V„ in smooth muscle. Am. J. Physiol. 1987, 252, H1049.
-
(1987)
Am. J. Physiol.
, vol.252
-
-
Moreland, S.1
Moreland, R.S.2
-
23
-
-
0025105557
-
Dihydropyrimidine Calcium Channel Blockers. 2. 3-Substituted-4-aryl-l, 4-dihydro-6-methyl-5-pyrimidinecarboxylic Acid Esters as Potent Mimics of Dihydropyridines
-
Atwal, K. S.; Rovnyak, G. C.; Kimball, S. D.; Floyd, D. M.; Moreland, S.; Swanson, B. N.; Gougoutas, J. Z.; Schwartz, J.; Smillie, K. M.; Malley, M. F. Dihydropyrimidine Calcium Channel Blockers. 2. 3-Substituted-4-aryl-l, 4-dihydro-6-methyl-5-pyrimidinecarboxylic Acid Esters as Potent Mimics of Dihydropyridines. J. Med. Chem. 1990, 33, 2629.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 2629
-
-
Atwal, K.S.1
Rovnyak, G.C.2
Kimball, S.D.3
Floyd, D.M.4
Moreland, S.5
Swanson, B.N.6
Gougoutas, J.Z.7
Schwartz, J.8
Smillie, K.M.9
Malley, M.F.10
-
24
-
-
0026065919
-
Dihydropyrimidine Calcium Channel Blockers. 3. 3-Car-bamoyl-4-aryl-l, 2, 3, 4-tetrahydro-6-methyl-5-pyrimidinecarboxγ-lic Add Ester as Orally Effective Antihypertensive Agents
-
Atwal, K. S.; Swanson, B. N.; Unger, S. E.; Floyd, D. M.; Moreland, S.; Hedberg, A.; O’Reilly, B. C. Dihydropyrimidine Calcium Channel Blockers. 3. 3-Car-bamoyl-4-aryl-l, 2, 3, 4-tetrahydro-6-methyl-5-pyrimidinecarboxγ-lic Add Ester as Orally Effective Antihypertensive Agents. J. Med. Chem. 1991, 34, 806.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 806
-
-
Atwal, K.S.1
Swanson, B.N.2
Unger, S.E.3
Floyd, D.M.4
Moreland, S.5
Hedberg, A.6
O’Reilly, B.C.7
-
25
-
-
0026759681
-
Dihydropyrimidine Calcium Channel Blockers. 4. Basic 3-Substituted-4-aryl-l, 4-dihydropyrimidine-5-carboxylic Acid Esters. Potent Antihypertensive Agents
-
Rovnyak, G. C.; Atwal, K. S.; Hedberg, A.; Kimball, S. D.; Moreland, S.; Gougoutas, J. Z.; O’Reilly, B. C.; Schwartz, J.; Malley, M. F. Dihydropyrimidine Calcium Channel Blockers. 4. Basic 3-Substituted-4-aryl-l, 4-dihydropyrimidine-5-carboxylic Acid Esters. Potent Antihypertensive Agents. J. Med. Chem. 1992, 35, 3254.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 3254
-
-
Rovnyak, G.C.1
Atwal, K.S.2
Hedberg, A.3
Kimball, S.D.4
Moreland, S.5
Gougoutas, J.Z.6
O’Reilly, B.C.7
Schwartz, J.8
Malley, M.F.9
-
26
-
-
0027731815
-
Molecular Localization of Regions in the L-Type Calcium Channel Critical for Dihydropyridine Action
-
Tang, S.; Yatani, A.; Bahinski, A.; Mori, Y.; Schwartz, A. Molecular Localization of Regions in the L-Type Calcium Channel Critical for Dihydropyridine Action. Neuron 1993, 11, 1013.
-
(1993)
Neuron
, vol.11
, pp. 1013
-
-
Tang, S.1
Yatani, A.2
Bahinski, A.3
Mori, Y.4
Schwartz, A.5
-
27
-
-
0025870869
-
Dihydropyrimidine Calcium Channel Bockers 5. Bicyclic Dihydropyrimidines as Potent Mimics of Dihydropyridines
-
Atwal, K. S.; Moreland, S. Dihydropyrimidine Calcium Channel Bockers 5. Bicyclic Dihydropyrimidines as Potent Mimics of Dihydropyridines. Bioorg. Med. Chem. Lett. 1991, 1, 291.
-
(1991)
Bioorg. Med. Chem. Lett.
, vol.1
, pp. 291
-
-
Atwal, K.S.1
Moreland, S.2
-
28
-
-
0001235201
-
Synthesis of Substituted 1, 2, 3, 4-Tetrahydro-6-methyl-thioxo-5-pyrimidinecarboxylic Acid Esters
-
Atwal, K. S.; O’Reilly, B. C.; Gougoutas, J. Z.; Malley, M. Synthesis of Substituted 1, 2, 3, 4-Tetrahydro-6-methyl-thioxo-5-pyrimidinecarboxylic Acid Esters. Heterocycles 1987, 26, 1189.
-
(1987)
Heterocycles
, vol.26
, pp. 1189
-
-
Atwal, K.S.1
O’Reilly, B.C.2
Gougoutas, J.Z.3
Malley, M.4
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