Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: A novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach

Journal of Pharmacology and Experimental Therapeutics

Volumn 274, Issue 3, 1995, Pages 1531-1537

  Chan, C C ^a   Boyce, S ^a   Brideau, C ^a   Ford Hutchinson, A W ^a   Gordon, R ^a   Guay, D ^a   Hill, R G ^a   Li, C S ^a   Mancini, J ^a   Penneton, M ^a   Prasit, P ^a   Rasori, R ^a   Riendeau, D ^a   Roy, P ^a   Tagari, P ^a   Vickers, P ^a   Wong, E ^a   Rodger, I W ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; CHROMIUM 51; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; FLURBIPROFEN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANALGESIA; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; ENZYME INHIBITION; ENZYME SPECIFICITY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIMATE; PRIORITY JOURNAL; RAT; STOMACH ULCER; ULCEROGENESIS;

ANIMAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; CARRAGEENAN; CHROMIUM RADIOISOTOPES; CYCLOOXYGENASE INHIBITORS; CYTOCHROME-C OXIDASE; EDEMA; FECES; FEVER; HUMAN; HYPERALGESIA; INDANS; ISOENZYMES; MALE; PLEURISY; RATS; RATS, SPRAGUE-DAWLEY; SAIMIRI; STOMACH ULCER; TUMOR CELLS, CULTURED;

EID: 0029033219     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)