Design and Evaluation of Nonpeptide Fibrinogen γ-Chain Based GPIIb/IIIa Antagonists

Journal of Medicinal Chemistry

Volumn 38, Issue 10, 1995, Pages 1582-1592

  Hoekstra, William J ^a   Beavers, Mary Pat ^a   Andrade Gordon, Patricia ^a   Evangelista, Mary F ^a   Keane, Patricia M ^a   Press, Jeffery B ^c   Tomko, Karen A ^a   Fan, Francis ^d   Kloczewiak, Marek ^e   Mayo, Kevin H ^d   Durkin, Kathleen A ^b   Liotta, Dennis C ^b  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

^b EMORY UNIVERSITY   (United States)

^c Emisphere Technologies Inc   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^e CURIS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [1 [3 (4 PIPERIDINYL)PROPIONYL]NIPECOTOYLAMINO]PROPIONIC ACID; ANTITHROMBOCYTIC AGENT; ARGINYLGLYCYLASPARTIC ACID; COLLAGEN; FIBRINOGEN; FIBRINOGEN RECEPTOR; FIBRINOGEN RECEPTOR ANTAGONIST; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA; N [1 [3 (4 PIPERIDYL)PROPIONYL]NIPECOTOYL] BETA ALANINE; PENTAPEPTIDE; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; FIBRINOGEN SYNTHESIS; INHIBITION KINETICS; NUCLEAR MAGNETIC RESONANCE; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION;

AMINO ACID SEQUENCE; DRUG DESIGN; FIBRINOGEN; HUMAN; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEINS;

EID: 0029031716     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00010a002     Document Type: Article

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