Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects

EMBO Journal

Volumn 14, Issue 12, 1995, Pages 2857-2865

  Harrison, Douglas A ^a   Binari, Richard ^a   Nahreini, Theresa Stines ^b   Gilman, Michael ^b,c   Perrimon, Norbert ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^c ARIAD PHARMACEUTICALS INC   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Drosophilia; Hematopoiesis; JAK tyrosine kinase; Neoplasia; Signal transduction

Indexed keywords

PROTEIN KINASE; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL CULTURE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DROSOPHILA; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HEMATOPOIESIS; LARVA; LETHAL MUTANT; LYMPH NODE HYPERPLASIA; MELANOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALIA; HUMULUS; JANUS; MAMMALIA;

EID: 0029031668     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1995.tb07285.x     Document Type: Article

References (17)

1. Argelsinger,L.S., Cumpbell,G.S., Yang,X., Witlhuhn,B. A., Sikennoirien,O., Ihlc,J.N. and Carter-Su,C. (1993) Cell. 74, 237-244.
2. Baserga,R. (1994) Cell. 79, 927-930.
3. Binari,R. and Perrimon,N. (1994) Genes Dev., 8, 300-312.
4. Brand,A.H. and Perrimon,N. (1993) Development. 118, 401-415.
5. Brand,A.H. and Perrimon,N. (1994) Genes Dev., 8, 629-639.
6. Brand,A.H., Manoukiun,A.S. and Perrimon,N. (1994) Methods Cell Biol., 44, 634-654.
7. Briscoe, J., Guschin,D. and Muller,M. (1994) Curr. Biol., 4, 1033-1035.
8. Bryant,P.J. (1978) In Ashbumer,M. and Wright,T.R.F (eds). The Genetics and Biology of Drosophila. Academic Press. London. Vol. 2C. pp. 230-335.
9. Sturgill,T.W. and Wu,J. (1991) Biochim. Biophys. Acta. 1092, 350-357.
10. Thummel,C.S. and Pirrotta,V. (1992) Drosophila Information Service. 71, 150.
11. Traugh,J.A. and Pendergast,A.M. (1986) Prog. Nucleic Acid Res. Mol. Biol., 33, 195-230.
12. Watson,K.L., Johnson,T.K. and Denell,R.E. (1991) Dev. Genet., 12, 173-187.
13. Watson,K.L., Konrad,K.D., Woods,D.K and Bryanl,P.J. (1992) Proc Null Acud. Sci. USA 89, 11302-11306.
14. Wilks,A.F and Harpur,A.G. (1994) BioEssasy. 16, 313-320.
15. Wilks,A.F. Harpur,A.G., Kurhan,R.R., Ralph,S.J., Zurcher,G. and Ziemiecki,A. (1991) Mol. Cell. Biol., 11, 2057-2065.
16. Witthuhn,B.A., Quelle,F.W., Silvennoinen.O., Yi,T. Tang,B., Miura,O. and Ihlc,J.N. (1993) Cell. 74, 227-236.
17. Woods,D.F. and Bryant,P.J. (1989) Dev. Biol., 134. 222-235.