Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant?

Biochemical Pharmacology

Volumn 50, Issue 1, 1995, Pages 123-126

  Ou, Peimian ^a   Tritschler, Hans J ^b   Wolff, Simon P ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b ASTA MEDICA AG   (Germany)

Author keywords

antioxidant; diabetes; lipoic thioctic acid; metal chelation

Indexed keywords

AMINOTRIAZOLE; ANTIOXIDANT; ASCORBIC ACID; CATALASE; CHELATING AGENT; COPPER; HYDROGEN PEROXIDE; OCTANOL; PHENANTHROLINE; THIOCTIC ACID;

ANTIOXIDANT ACTIVITY; ARTICLE; CHELATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETIC NEUROPATHY; ENANTIOMER; ERYTHROCYTE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPID PEROXIDATION; LIPOPHILICITY; PRIORITY JOURNAL; RACEMIC MIXTURE;

ANTIOXIDANTS; ASCORBIC ACID; CHELATING AGENTS; COPPER; DIABETIC NEUROPATHIES; ERYTHROCYTES; HUMANS; HYDROGEN PEROXIDE; OXIDATION-REDUCTION; THIOCTIC ACID;

EID: 0029031443     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)00116-H     Document Type: Article

References (16)

1. Dihydrolipoic acid—a universal antioxidant both in the membrane and in the aqueous phase
2. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species
3. Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on α-tocopherol
4. Interaction between lipoic acid and glutathione in the protection against microsomal lipid peroxidation
5. Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation
6. 2+ in solution
7. The effect of dl-α-lipoic acid on heavy metal intoxication in mice and dogs
8. Diabetes mellitus and free radicals
9. The role of oxidative stress in the development of complications in diabetes
10. Spirohydantoin inhibitors of aldose reductase inhibit iron- and copper-catalysed ascorbate oxidation in vitro
11. 2+-oxidation method for detection of lipid peroxide in low density lipoprotein and liposomes
12. Ferrous ion oxidation in the presence of the ferric ion indicator xylenol orange for the measurement of hydroperoxides: the “FOX” assay
13. A study of the inhibition of catalase by 3-amino-1:2:4:-triazole.
14. 2 production) by ascorbic acid and glucose in the presence of aminotriazole: Role of transition metals and relevance to diabetes
15. Aminoguanidine: a drug proposed for prophylaxis in diabetes inhibits catalase an generates hydrogen peroxide in vitro
16. Lipid solubility of a series of drugs and its relevance to fatal poisoning