BDNF Protein Measured by a Novel Enzyme Immunoassay in Normal Brain and after Seizure: Partial Disagreement with mRNA Levels

European Journal of Neuroscience

Volumn 7, Issue 7, 1995, Pages 1527-1535

  Nawa, Hiroyuki ^a   Carnahan, Josette ^b   Gall, Christine ^c  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b AMGEN INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

entorhinal cortex; hippocampus; neuropeptide Y; neurotrophin; seizure

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN ENZYME; GROWTH FACTOR; MESSENGER RNA; NEUROPEPTIDE Y; NEUROTROPHIN;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELL DIFFERENTIATION; CEREBELLUM; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; CORPUS STRIATUM; ENTORHINAL CORTEX; ENZYME IMMUNOASSAY; FEMALE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HYPOTHALAMUS; MALE; NEOCORTEX; NONHUMAN; PEPTIDERGIC NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; RAT; THALAMUS;

ANIMAL; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; IMMUNOENZYME TECHNIQUES; LIMBIC SYSTEM; MALE; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEUROPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; RNA, MESSENGER; SEIZURES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 0029031207     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1995.tb01148.x     Document Type: Article

References (61)

1. Brain‐derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture
2. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain
3. Purification of a new neurotrophic factor from mammalian brain
4. Enhanced rate of expression and biosynthesis of neuropeptide Y after kainic acid‐induced seizures
5. Limbic seizures and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy
6. Neurotrophin‐5: a novel neurotrophic factor that activates trk and trkB
7. Glutamate receptor agonists enhance the expression of BDNF mRNA in cultured cerebellar granule cells
8. Light regulates expression of brain‐derived neurotrophic factor mRNA in rat visual cortex
9. The induction of LTP increases BDNF and NGF mRNA but decreases NT‐3 mRNA in the dentate gyrus
10. Regulation of neuropeptides in adult rat forebrain by the neurotrophins BDNF and NGF
11. The neurotrophins BDNF, NT‐3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons
12. Systemic administration of kainic acid differentially regulates the levels of prodynorphin and proenkephalin mRNA and peptides in the rat hippocampus
13. Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family
14. Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis
15. Cells that express brain‐derived neurotrophic factor mRNAs in the developing postnatal rat brain
16. Seizures induce dramatic and distinctly different changes in enkephalin, dynorphin, and cholecystokinin immunoreactivities in mouse hippocampal mossy fibers
17. Seizures and the regulation of neurotrophic factor and neuropeptide gene expression in brain
18. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary
19. Regional distribution of brain‐derived neurotrophic factor mRNA in the adult mouse brain
20. Identification and characterization of a novel member of the nerve growth factor/brain‐derived neurotrophic factor family
21. Regulation of brain‐derived neurotrophic factor messenger RNA and protein at the cellular level in pentylenetetrazol‐induced epileptic seizures
22. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
23. Cultured hippocampal neurons show responses to BDNF, NT‐3, and NT‐4, but not NGF
24. BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF
25. Production, purification and characterization of biologically active recombinant human nerve growth factor
26. Brain‐derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells
27. Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development
28. Dynorphin‐ and enkephalin‐like immunoreactivity is altered in limbic—basal ganglia regions of rat brain after repeated electroconvulsive shock
29. The trkB tyrosine kinase is a receptor for brain‐derived neurotrophic factor and neurotrophin‐3
30. Promotion of central cholinergic and dopaminergic neuron differentiation by brain‐derived neurotrophic factor but not neurotrophin‐3
31. Brain‐derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain
32. The neurotrophic factor concept: a reexamination
33. Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation
34. Two‐site enzyme immunoassay for nerve growth factor
35. Developmental changes of nerve growth factor levels in sympathetic ganglia and their target organs
36. Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation
37. Molecular cloning and expression of brain‐derived neurotrophic factor
38. Brain‐derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate‐induced neurotoxicity
39. Neurotrophin‐3: a neurotrophic factor related to NGF and BDNF
40. NT‐3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression
41. Enhanced synthesis of brain‐derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA
42. Brain‐derived neurotrophic factor promotes differentiation of striatal GABAergic neurons
43. Differential biological activities in conditioned media control the expression of a variety of neuropeptides in cultured sympathetic neurons
44. Regulation of neuropeptide expression in cultured cerebral cortical neurons by brain‐derived neurotrophic factor
45. Intraventricular administration of BDNF increases neuropeptide expression in newborn rat brain
46. Regulation of BDNF protein and neuropeptides after limbic seizures
47. Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT‐3 mRNAs
48. Widespread expression of BDNF but not NT‐3 by target areas of basal forebrain cholinergic neurons
49. Hippocampal epileptogenesis produced by electric iron deposition in the rat dentate gyrus
50. Modulation of seizure activity by electrical stimulation: II. Motor seizure
51. Brain‐derived neurotrophic factor enhances striatal neuropeptide expression in both the intact and the dopamine‐depleted rat striatum
52. Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor
53. Processing of protein precursors by a novel family of subtilisin‐related mammalian endoproteases
54. Functional changes in neuropeptide Y‐ and somatostatin‐containing neurons induced by limbic seizures in the rat
55. The changing scene of neurotrophic factors
56. Localization of brain‐derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization
57. Regulation of brain‐derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non‐NMDA type glutamate receptors
58. Differential regulation of neuropeptide and protooncogene mRNA content in the hippocampus following recurrent seizures
59. Neurotrophic factors, their receptors, and the signal transduction pathways they activate
60. Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non‐NMDA glutamate receptors