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Volumn 5, Issue 13, 1995, Pages 1415-1420

Novel indolactam-based inhibitors of matrix metalloproteinases

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; ENZYME INHIBITOR; GELATINASE; LACTAM; STROMELYSIN;

EID: 0029031001     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(95)00233-J     Document Type: Article
Times cited : (51)

References (39)
  • 21
    • 84921221626 scopus 로고    scopus 로고
    • Porter, J. R.; Millican, T. A.; Morphy J. R.; Beeley, N. R. A. European Patent Application EP 0489577 A1, 1992.
  • 26
    • 84921221625 scopus 로고    scopus 로고
    • 4-/NaOH/benzene in 77% yield.
  • 27
    • 84921221624 scopus 로고    scopus 로고
    • 2-ind), 121.83(d, C [[Truncated]]
  • 30
    • 84921221622 scopus 로고    scopus 로고
    • Castelhano, A. L.; Liak, T. J.; Horne, S.; Yuan, Z.; Krantz, A. World Patent WO9504735-A1, 1995
  • 34
    • 84921221621 scopus 로고    scopus 로고
    • The Tyrosine cyclic analog of 1c (C-terminal amide nitrogen joined to the phenol group by a six-methylene linker) is equipotent to the acyclic counterpart.
  • 36
    • 84921221620 scopus 로고    scopus 로고
    • As determined in a dipeptidic series, the acetyl analog is relatively inactive; see also ref 10a.
  • 37
    • 84921221619 scopus 로고    scopus 로고
    • The activity of the 12-membered analog of 1b, prepared in low yield by following the steps in Scheme 1 but substituting with 5-amino-1-pentanol, is about 2–3 times higher than 1b.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.