Calcium-channel antibodies in the lambert—eaton syndrome and other paraneoplastic syndromes

New England Journal of Medicine

Volumn 332, Issue 22, 1995, Pages 1467-1475

  Lennon, Vanda A ^a   Kryzer, Thomas J ^a   Griesmann, Guy E ^a   O’suilleabhain, Padraig E ^a   Windebank, Anthony J ^a   Woppmann, Andreas ^b   Miljanich, George P ^b   Lambert, Edward H ^a  

^a Carrick Institute   (United States)

^b Neurex Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CALCIUM 45; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; NIFEDIPINE; PEPTIDE; RECEPTOR;

ANTIBODY TITER; ARTICLE; AUTOIMMUNITY; BRAIN CORTEX; CALCIUM TRANSPORT; CEREBELLUM; CONTROLLED STUDY; DEPOLARIZATION; EATON LAMBERT SYNDROME; ETIOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; MAJOR CLINICAL STUDY; PARANEOPLASTIC SYNDROME; PRIORITY JOURNAL; SMALL CELL CARCINOMA;

AUTOANTIBODIES; CALCIUM CHANNELS; CARCINOMA, SMALL CELL; HUMAN; LAMBERT-EATON MYASTHENIC SYNDROME; LUNG NEOPLASMS; NEURONS; PARANEOPLASTIC SYNDROMES; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0029030949     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199506013322203     Document Type: Article

References (40)

1. Lennon VA Paraneoplastic autoantibodies: the case for a descriptive generic nomenclature. Neurology 1994; 44: 2236-40, 2412
2. Oguro-Okano M, Griesmann GE, Wieben ED, Slaymaker S, Snutch TP, Lennon VA Molecular diversity of neuronal-type calcium channels identified in small cell lung carcinoma. Mayo Clin Proc 1992; 67: 1150-1159
3. Oguro-Okano M, Griesmann GE, Kryzer T, Wieben ED, Lennon VA N-type (class B) neuronal Ca2+ channels expressed in small cell lung carcinomas of patients with and without Lambert-Eaton myasthenic syndrome (LES). Soc Neurosci Abstr 1993; 19: 1755-1755
4. Codignola A, Tarroni P, Clementi F, Calcium channel subtypes controlling serotonin release from human small cell lung carcinoma cell lines. J Biol Chem 1993; 268: 26240-26247
5. Szabo A, Dalmau J, Manley G, HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. Cell 1991; 67: 325-333
6. Buckanovich RJ, Posner JB, Darnell RB. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. Neuron 1993:11:657-72.
7. Kiers L, Altermatt HJ, Lennon VA Paraneoplastic anti-neuronal nuclear IgG autoantibodies (type I) localize antigen in small cell lung carcinoma. Mayo Clin Proc 1991; 66: 1209-1216
8. Luque FA, Furneaux HM, Ferziger R, Anti-Ri: an antibody associated with paraneoplastic opsoclonus and breast cancer. Ann Neurol 1991; 29: 241-251
9. Looser P, Laissue JA Extrazellulä re Deoxyribonukleinsä ure in kleinzelligen Bronchuskarzinomen. Schweiz Med Wochenschr 1980; 110: 1342-1346
10. Fukunaga H, Engel AG, Lang B, Newsom-Davis J, Vincent A Passive transfer of Lambert-Eaton myasthenic syndrome with IgG from man to mouse depletes the presynaptic membrane active zones. Proc Natl Acad Sci U S A 1983; 80: 7636-7640
11. Lambert EH, Lennon VA Selected IgG rapidly induces Lambert-Eaton myasthenic syndrome in mice: complement independence and EMG abnormalities. Muscle Nerve 1988; 11: 1133-1145
12. McCann FV, Pettengill OS, Cole JJ, Russell JAG, Sorenson GD Calcium spike electrogenesis and other electrical activity in continuously cultured small cell carcinoma of the lung. Science 1981; 212: 1155-1157
13. Roberts A, Perera S, Lang B, Vincent A, Newsom-Davis J Paraneoplastic myasthenic syndrome IgG inhibits 45Ca2+ flux in a human small cell carcinoma line. Nature 1985; 317: 737-739
14. De Aizpurua HJ, Lambert EH, Griesmann GE, Olivera BM, Lennon VA Antagonism of voltage-gated calcium channels in small cell carcinomas of patients with and without Lambert-Eaton myasthenic syndrome by autoantibodies omega-conotoxin and adenosine. Cancer Res 1988; 48: 4719-4724
15. Sher E, Biancardi E, Passafaro M, Clementi F Physiopathology of neuronal voltage-operated calcium channels. FASEB J 1991; 5: 2677-2683
16. Birnbaumer L, Campbell KP, Catterall WA, The naming of voltage-gated calcium channels. Neuron 1994; 13: 505-506
17. Zhang JF, Randall AD, Ellinor PT, Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology 1993; 32: 1075-1088
18. Olivera BM, Miljanich GP, Ramachandran J, Adams ME Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins. Annu Rev Biochem 1994; 63: 823-867
19. Lennon VA. Serological diagnosis of myasthenia gravis and the Lambert-Eaton myasthenic syndrome. In: Lisak R, ed. Handbook of myasthenia gravis. New York: Marcel Dekker, 1994:149-64.
20. Uchitel OD, Protti DA, Sanchez V, Cherksey BD, Sugimori M, Llinas R P-type voltage-dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses. Proc Natl Acad Sci U S A 1992; 89: 3330-3333
21. Sugiura Y, Woppmann A, Miljanich GP, Ko C-P A novel ω -conopeptide for the presynaptic localization of calcium channels at the mammalian neuromuscular junction. J Neurocytol 1995; 24: 15-27
22. Hillyard DR, Monje VD, Mintz IM, A new Conus peptide ligand for mammalian presynaptic Ca2+ channels. Neuron 1992; 9: 69-77
23. Kristipati R, Nadasdi L, Tarczy-Hornoch K, Characterization of the binding of omega-conopeptides to different classes of non-L-type neuronal calcium channels. Mol Cell Neurosci 1994; 5: 219-228
24. Wheeler DB, Randall A, Tsien RW Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission. Science 1994; 264: 107-111
25. Cunningham JM, Lennon VA, Lambert EH, Scheithauer B Acetylcholine receptors in small cell carcinomas. J Neurochem 1985; 45: 159-167
26. Williams CL, Lennon VA Activation of M3 muscarinic acetylcholine receptors inhibits voltage-dependent calcium influx in small cell lung carcinoma. J Biol Chem 1990; 265: 1443-1447
27. Williams CL, Lennon VA Activation of muscarinic acetylcholine receptors inhibits cell cycle progression of small cell lung carcinoma. Cell Regul 1991; 2: 373-381
28. Lennon VA, Kryzer T, Griesmann GE, P-like Ca2+ channels in human cerebellum and small cell lung carcinoma bind ω -conotoxin-MVIIC and are immunoprecipitable by Lambert-Eaton myasthenic syndrome (LES) IgGs that react highly with N-type Ca2+ channels. Soc Neurosci Abstr 1993; 19: 1753-1753
29. Lennon VA Reactivity of Lambert-Eaton autoantibodies with voltage-gated calcium channel complex of human cerebral cortex. Ann Neurol 1990; 28: 281-281
30. Lennon VA, Lambert EH Autoantibodies bind solubilized calcium channel-omega-conotoxin complexes from small cell lung carcinoma: a diagnostic aid for Lambert-Eaton myasthenic syndrome. Mayo Clin Proc 1989; 64: 1498-1504
31. Triggle DJ, Rampe D 1,4-Dihydropyridine activators and antagonists: structural and functional distinctions. Trends Pharmacol Sci 1989; 10: 507-511
32. Lennon VA, Kryzer T, Griesmann GE, Miljanich G, Ramachandran J, Lambert EH Human neuronal P-like calcium channels (omega-conotoxin-MVIIC-receptors) are immunoprecipitated by serum IgG of patients with various central and peripheral nervous system disorders, with and without evidence of tumor. Muscle Nerve 1994; 1: S22-S22 abstract.
33. Furneaux HM, Rosenblum MK, Dalmau J, Selective expression of Purkinje-cell antigens in tumor tissue from patients with paraneoplastic cerebellar degeneration. N Engl J Med 1990; 322: 1844-1851
34. Sher E, Gotti C, Canal N, Specificity of calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome. Lancet 1989; 2: 640-643
35. Leys K, Lang B, Johnston I, Newsom-Davis J Calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome. Ann Neurol 1991; 29: 307-314
36. Rosenfeld MR, Wong E, Dalmau J, Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen. Ann Neurol 1993; 33: 113-120
37. Leveque C, Hoshino T, David P, The synaptic vesicle protein synaptotagmin associates with calcium channels and is a putative Lambert-Eaton myasthenic syndrome antigen. Proc Natl Acad Sci U S A 1992; 89: 3625-3629
38. O'Suilleabhain PE, Lambert EH, Lennon VA Anti-voltage-gated calcium channel antibodies in women with paraneoplastic cerebellar degeneration (PCD) and seropositivity for type 1 anti-Purkinje cell antibody (PCAb1+). Neurology 1994; 44: Suppl 2: A157-A157 abstract.
39. Smith RG, Hamilton S, Hofmann F, Serum antibodies to L-type calcium channels in patients with amyotrophic lateral sclerosis. N Engl J Med 1992; 327: 1721-1728
40. Llinas R, Sugimori M, Cherksey BD, IgG from amyotrophic lateral sclerosis patients increases current through P-type calcium channels in mammalian cerebellar Purkinje cells and in isolated channel protein in lipid bilayer. Proc Natl Acad Sci U S A 1993; 90: 11743-11747