Possibilities for the pharmacological exploitation of ischaemic preconditioning

Journal of Molecular and Cellular Cardiology

Volumn 27, Issue 4, 1995, Pages 991-1000

  Parratt, James R ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Adenosine; Cyclic nucleotides; Endogenous myocardial protective substances; G proteins; Ischaemic preconditioning; Nitric oxide; Pharmacological exploitation; Phosphodiesterase inhibitors; Protein kinase C; Signal transduction

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM); ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC GMP; GUANINE NUCLEOTIDE BINDING PROTEIN; NITRIC OXIDE; NORADRENALIN; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN KINASE C;

ENZYME INDUCTION; HEART ARRHYTHMIA; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART MUSCLE REPERFUSION; HEART PROTECTION; HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW;

ANIMAL; CORONARY DISEASE; DOGS; ENZYME ACTIVATION; GTP-BINDING PROTEINS; HEART; HUMAN; MICE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NITRIC OXIDE; NUCLEOTIDES, CYCLIC; PHOSPHORIC DIESTER HYDROLASES; PROTEIN KINASE C; RECEPTORS, PURINERGIC P1; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T;

EID: 0029029991     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-2828(95)90068-3     Document Type: Review

References (81)

1. Nitric oxide: mediator, murderer, and medicine
2. 3 receptor involvement
3. Ramiprilat increases bradykinin outflow from isolated hearts of rat
4. A ‘second window of protection’ 24 hours are ischemic preconditioning may be dependent upon adenosine receptor activation
5. Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning
6. Phorbol ester-induced ventricular fibrillation in the Langendorff-perfused rabbit heart: antagonism by staurosporine and glibenclamide
7. Long lasting anti-adrenergic effect of 7-oxo-prostacyclin in the heart: a cyclohexamide sensitive increase of phosphodiesterase isoform I and IV activities
8. Bradykinin receptors mediate preconditioning through protein kinase
9. Ionic channels and their regulation by G protein subunits
10. Protein kinase C activation and cardiac stunning
11. ATP sensitive potassium channel openers are of potential benefit in ischaemic heart disease
12. Ischaemic preconditioning: can the protection be bottled?
13. The effects of nafazatrom on arrhythmias and prostanoid release during coronary artery-occlusion and reperfusion in anaesthetised greyhounds
14. An explanation for the reported observation that ATP dependent potassium channel openers mimic preconditioning
15. Adenosine and the anti-infarct effects of preconditioning
16. Experimental issues in assessment of G protein function in cardiac disease
17. Role of myocardial ATP-sensitive potassium channels in mediating preconditioning in the dog heart and their possible interation with adenosine A 1-receptors
18. Enhanced basal nitric oxide production in heart failure: another failed counter-regulatory vasodilation mechanism?
19. Sublethal ischemia alters myocardial antioxidant activity in canine heart
20. Adenosine blockade during reperfusion reverses the infarct limiting effect in preconditioned canine hearts
21. + exchange
22. + channel in guinea pig ventricular cell membrane
23. Nucleoside transport inhibitors enhance the infarct size-limiting effect of preconditioning
24. Nucleoside transport inhibitors enhance the infarct size-limiting effect of ischemic preconditioning
25. Myocardial cyclic nucleotide levels following coronary artery ligation
26. G-protein control of cardiac potassium channels
27. Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia
28. Pertussis toxin blocks
29. 3 receptors: pharmacological properties, species differences and receptor functions
30. Does protein kinase C play a role in ischemic preconditioning in the rat?
31. 1 adenosine receptors in rabbit heart
32. 3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart
33. Evidence that translocation of protein kinase C is a key event during ischemic preconditioning of rabbit myocardium
34. Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction
35. Protein kinase C mediates preconditioning in isolated rat heart (Abstract)
36. Acid optimum kininogenase in canine myocardium and aorta
37. Myocardial preconditioning
38. Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury
39. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium
40. Cardioprotection by angiotensin converting enzyme inhibitors — the experimental evidence
41. Protection of the heart by ischaemic preconditioning: mechanisms and possibilities for pharmacological exploitation
42. Nitric oxide and cardiovascular dysfunction in sepsis and endotoxaemia — an introduction and an overview
43. The role of the l-arginine nitric oxide pathway in sepsis
44. Pronounced antiarrhythmic effects of ischemic preconditioning
45. 2) receptors, mediates the pronounced antiarrhythmic effects of ischaemic preconditioning in anaesthetised dogs
46. The antiarrhythmic effect of ischaemic preconditioning in isolated rat heart involves a pertussis toxin sensitive mechanism
47. Guanine-nucleotide binding regulatory proteins as targets for novel drugs
48. Ischaemic preconditioning in the rat heart: the role of G-proteins and adrenergic stimulation
49. Doubleedged role of endogenous nitric oxide
50. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial oxide synthase gene expression
51. Protein kinase C
52. Interactions between phorbol-12,13-dibutyrate and lignocaine in sheep purkinje fibres
53. 1-receptor-independent activation of protein kinase C in acute myocardial ischemia
54. 2 and its possible mode of action
55. Cardioprotection endogenous protective mechanisms promoted by prostacyclin
56. 2 induced late appearing and long lasting electrophysiological changes in the heart in situ of the rabbit, guinea-pig, dog and cat
57. Pretreatment with pertussis toxin blocks the protective effects of preconditioning: evidence for a G-protein mechanism
58. Acadesine lowers temporal threshold for the myocardial infarct size limiting effect of preconditioning
59. Role of adenosine receptor activation in myocardial infarct size limitation by ischaemic preconditioning
60. 1-selective agonist is diminished after prolonged infusion as is the cardioprotective effect of ischaemic preconditioning in rabbit heart
61. Nucleoside transport inhibition: a therapeutic approach to cardioprotection via adenosine?
62. Adenosine slows ischaemic metabolism in canine myocardium in vitro: Relationship to ischaemic preconditioning
63. Antiarrhythmic effects of preconditioning in anaesthetised dogs and rats
64. Preconditioning of the ischaemic myocardium: involvement of the L-arginine nitric oxide pathway
65. The local intracoronary administration of methylene blue prevents the pronounced antiarrhythmic effect of ischaemic preconditioning
66. Cardiac pacing in anesthetised dogs preconditions the heart against arrhythmias when ischaemia is induced 24 h later
67. Dexamethasone prevents the marked antiarrhythmic effects of preconditioning induced twenty hours after rapid cardiac pacing
68. Pronounced antiarrhythmic effects of preconditioning in anaesthetised dogs: Is adenosine involved?
69. 2 receptors
70. Protective effect of preconditioning of the ischaemic myocardium involves cyclooxygenase products
71. The antiarrhythmic effects of the nucleoside transporter inhibitor, R75231, in anaesthetised pigs
72. Concentration-dependent effects of protein kinase C-activating and nonactivating phorbol esters on myocardial contractility, coronary resistance, energy metabolism, prostacyclin synthesis, and ultrastructure in isolated rat hearts
73. A functional modification of Gi proteins is the underlying mechanism of ischaemic preconditioning
74. Protein kinase C: is its pivotal role in cellular activation over-stated?
75. G protein function in the ischaemic myocardium
76. Endotoxin protection against ischaemia-induced ventricular arrhythmias is attenuated by dexamethasone
77. Relationship between time interval from preconditioning to sustained ischemia and its effect on limiting infarct size
78. Preconditioning protects the ischemic rabbit heart by protein kinase C activation
79. Tumor-promoting phorbol esters inhibit cardiac functions and induce redistribution of protein kinase C in perfused beating rat heart
80. Enzymes in normally perfused and ischaemic dogs hearts which release a substance with kinin like activity