Deleterious Effects of Buthionine Sulfoximine on Cardiac Function During Continuous Endotoxemia

Proceedings of the Society for Experimental Biology and Medicine

Volumn 209, Issue 2, 1995, Pages 178-184

  Lee, Kevin J ^a   Andrejuk, Tomasz ^a   Dziuban, Stanley W ^a   Goldfarb, Roy D ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTHIONINE SULFOXIMINE; FREE RADICAL; GLUTATHIONE; SALMONELLA ENDOTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; HEART MUSCLE INJURY; HEART OUTPUT; HEART RATE; INOTROPISM; NONHUMAN; OXIDATIVE STRESS; SEPSIS; SWINE;

ANIMAL; BACTERIAL TOXINS; BUTHIONINE SULFOXIMINE; CARDIAC OUTPUT; CORONARY CIRCULATION; ENDOTOXINS; FEMALE; FREE RADICALS; GLUTATHIONE; HEART; HEART RATE; MALE; METHIONINE SULFOXIMINE; MYOCARDIAL CONTRACTION; SALMONELLA ENTERITIDIS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; SWINE;

EID: 0029027194     PISSN: 00379727     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/00379727-209-43893     Document Type: Article

References (36)

1. Parker MM, Shelhamer JH, Bacharach SL, Green MV, Natanson C, Frederick TM, Damske BA, Parrillo JE. Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 100:483–490, 1984.
2. Suffredini AF, Fromm RE, Parker MM, Brenner M, Kovacs JA, Wesley RA, Parrillo JE. The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 321:280–287, 1989.
3. Lee KJ, van der Zee H, Dziuban SW, Luhman K, Goldfarb RD. Left ventricular function during chronic endotoxemia in swine. Am J Physiol 254:H324–H330, 1988.
4. Lee KJ, Dziuban SW, van der Zee H, Goldfarb RD. Cardiac function and coronary flow in chronic endotoxemia pigs. Proc Soc Exp Biol Med 189:245–252, 1988.
5. Fish RE, Burns AH, Lang CH, Spitzer JA. Myocardial dysfunction in a non-lethal, non-shock model of chronic endotoxemia. Circ Shock 16:241–252, 1985.
6. Fish RE, Spitzer JA. Continuous infusion of endotoxin from an osmotic pump in the conscious, unrestrained rat: A unique model of chronic endotoxemia. Circ Shock 12:135–149, 1984.
7. Goldfarb RD, Nightingale LM, Kish P, Weber PB, Loegering DJ. Left ventricular function during lethal and sublethal endotoxemia in swine. Am J Physiol 251:H364–H373, 1986.
8. Breslow MJ, Miller CF, Parker S, Walman AT, Traystman RJ. Effect of catecholamines on organ blood flow during endotoxin shock in the pig. Crit Care Med 12:246, 1984.
9. Natanson C, Fink MP, Ballantyne HK, MacVittie TJ, Conklin JJ, Parrillo JE. Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock. J Clin Invest 78:259–270, 1986.
10. McKechnie K, Furman BL, Parratt JR. Modification by free radical scavengers of the metabolic and cardiovascular effects of endotoxin infusion in conscious rats. Circ Shock 19:429–439, 1986.
11. Traber DL, Adams T, Sziebert L, Stein M, Traber L. Potentiation of lung vascular response to endotoxin by superoxide dismutase. J Appl Physiol 58:1005–1009, 1985.
12. Manson NH, Hess ML. Interaction of oxygen free radicals and cardiac sarcoplasmic reticulum: Proposed role in the pathogenesis of endotoxin shock. Circ Shock 10:205–213, 1985.
13. Youn YK, LaLonda C, Demling R. Use of antioxidant therapy in shock and trauma. Circ Shock 35:245–249, 1991.
14. Bernard GR, Lucht WD, Niedermeyer ME, Snapper JR, Ogletree ML, Brigham KL. Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function. J Clin Invest 73:1772–1784, 1984.
15. Chang SW, Lanterburg BH, Voehel NF. Endotoxin causes a neutrophil independent oxidant stress in rats. J Appl Physiol 65:358–367, 1988.
16. Chen MF, Chen LT, Boyce HW. Effect of endotoxin on the rat colon glutathione level. Biochem Biophys Res Comm 151:844–850, 1988.
17. Kunimoto F, Morita T, Ogawa R, Fujita T. Inhibition of lipid peroxidation improves survival rate of endotoxemic rats. Circ Shock 21:15–22, 1987.
18. Movat HZ, Cybulsky MI, Colditz IG, Chan MKW, Dinarello CA. Acute inflammation in gram-negative infection: Endotoxin, interleukin-1, tumor necrosis factor, and neutrophils. Fed Proc 46:97–104, 1987.
19. Wilson ME. Effects of bacterial endotoxins on neutrophil function. Rev Infect Dis 7:404–418, 1985.
20. Raetz CRH, Ulevitch RJ, Wright SD, Sibley CH, Ding A, Nathan CF. Gram-negative endotoxin: An extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J 5:2652–2660, 1991.
21. Cunnion RE, Shaer GL, Parker MM, Natanson C, Parrillo JE. The coronary circulation in human septic shock. Circulation 73:637–644, 1986.
22. Hess ML, Thompson JA, Kureja RC. Myocardial failure and excitation-contraction uncoupling during the course of canine endotoxin and hemorrhagic shock. In: Dhalla NS, Singh PK, Beamish RE, Eds. Pathophysiology of Heart Disease. Boston: Nijhoff, pp 325–334, 1987.
23. Simmons TW, Jamall IS. Relative importance of intracellular glutathione peroxidase and catalase in vivo for prevention of peroxidation to the heart. Cardiovasc Res 23:774–779, 1989.
24. Singh A, Lee KJ, Lee CY, Goldfarb RD, Tsan MF. Relation between myocardial glutathione content and extent of ischemia-reperfusion injury. Circulation 80:1795–1804, 1989.
25. Cochrane CG, Schraufstatter IU, Hyslop P, Jackson J. Cellular and biochemical events in oxidant injury. In: Halliwell B, Ed. Oxygen Radicals and Tissue Injury. Bethesda: FASEB, pp 49–56, 1988.
26. Curello S, Ceconi C, Bignoli C, Ferrari R, Albertini A, Guarnieri C. Changes in cardiac glutathione status after ischemia and reperfusion. Experientia 41:42–43, 1985.
27. McCord JM. Oxygen-derived free radicals in post-ischemic tissue injury. N Engl J Med 312:159–163, 1985.
28. Griffith OW. Mechanism of action, metabolism and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J Biol Chem 257:13704–13712, 1985.
29. Sagawa K. The ventricular pressure-volume diagram revisited. Circ Res 43:677–687, 1978.
30. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal Biochem 27:502–522, 1969.
31. Meister A, Anderson ME. Glutathione. Annu Rev Biochem 52:711–760, 1983.
32. Robinson MK, Rounds JD, Hong RW, Jacobs DO, Wilmore DW. Glutathione deficiency increases organ dysfunction after hemorrhagic shock. Surgery 112:140–147, 1992.
33. Werns SW, Fantone JC, Ventura A, Lucchesi BR. Myocardial glutathione depletion impairs recovery of isolated blood perfused hearts after global ischemia. J Mol Cell Cardiol 24:1215–1220, 1992.
34. Deutschman CS, Kirsch JR, Breslow MJ, Miller CF, Traystman RJ. Failure of endotoxic shock to elicit superoxide anion production in pig brain. Circ Shock 31:149–158, 1990.
35. Peristeris P, Clark DB, Gatti S, Faggioni R, Mantovani A. N-acetyl-cysteine and glutathione as inhibitors of tumor necrosis factor. Cell Immunol 140:390–392, 1992.
36. Zhang H, Spapen H, Nugyen DN, Benlabed M, Buurman WA, Vincent, J-L. Protective effects of N-acetyl-L-cysteine in endotoxemia. Am J Physiol 266(Heart Circ Physiol 35): H1746–H1754, 1994.