Phosphinyl Acid-Based Bisubstrate Analog Inhibitors of Ras Famesyl Protein Transferase

Journal of Medicinal Chemistry

Volumn 38, Issue 3, 1995, Pages 435-442

  Patel, Dinesh V ^a   Gordon, Eric M ^a   Schmidt, Robert J ^b   Weller, Harold N ^b   Young, Marian G ^b   Zahler, Robert ^b   Barbacid, Mariano ^b   Carboni, Joan M ^b   Gullo Brown, Johnni L ^b   Hunihan, Lisa ^b   Ricca, Carol ^b   Robinson, Simon ^c   Seizinger, Bernd R ^b   Tuomari, Anne V ^b   Manne, Veeraswamy ^b  

^a AFFYMAX RESEARCH INSTITUTE   (United States)

^b BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^c BASF Bioresearch Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESYL TRANS TRANSFERASE; N [N [N [3 [HYDROXY(3,7,11 TRIMETHYL 1 OXO 2,6,10 DODECATRIENYL)PHOSPHINYL] 1 OXOPROPYL]VALYL]VALYL]METHIONINE; N [N [N [[[HYDROXY(3,7,11 TRIMETHYL 2,6,10 DODECATRIENYL)PHOSPHINYL]OXY]ACETYL]VALYL]LEUCYL]SERINE; N [N [N [[[HYDROXY(3,7,11 TRIMETHYL 2,6,10 DODECATRIENYL)PHOSPHINYL]OXY]ACETYL]VALYL]VALYL]METHIONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CELL PROLIFERATION; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; ONCOGENE RAS; STRUCTURE ACTIVITY RELATION; SWINE;

3T3 CELLS; ANIMAL; BRAIN; MICE; PHOSPHINIC ACIDS; SUBSTRATE SPECIFICITY; SWINE; TRANSFERASES;

EID: 0029025272     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00003a006     Document Type: Article

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