Synthesis of Novel Imidazobenzodiazepines as Probes of the Pharmacophore for “Diazepam-Insensitive” GABAA Receptors

Journal of Medicinal Chemistry

Volumn 38, Issue 10, 1995, Pages 1679-1688

  Zhang, Puwen ^a   Zhang, Weijiang ^a   Liu, Ruiyan ^a   Harris, Bradford ^b   Skolnick, Phil ^b   Cook, James M ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; BENZODIAZEPINE DERIVATIVE; IMIDAZOLE DERIVATIVE;

ANTICONVULSANT ACTIVITY; ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MUSCLE RELAXATION; RECEPTOR AFFINITY; SEDATION; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

AFFINITY LABELS; ANIMAL; AZIDES; BENZODIAZEPINES; DIAZEPAM; MALE; MOLECULAR PROBES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029024838     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00010a013     Document Type: Article

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