The Biochemistry and Cell Biology of Antigen Presentation by MHC Class I and Class II Molecules: Implications for Development of Combination Vaccines

Annals of the New York Academy of Sciences

Volumn 754, Issue 1, 1995, Pages 114-125

  GERMAIN, RONALD N ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR; VACCINE;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; B LYMPHOCYTE; BIOCHEMISTRY; CONFERENCE PAPER; CYTOLOGY; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; T LYMPHOCYTE; VACCINATION;

EID: 0029023979     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1995.tb44444.x     Document Type: Article

References (58)

1. Immunogenicity and antigen structure
2. Genes of the major histocompatibility complex of the mouse
3. T‐cell antigen receptor genes and T‐cell recognition
4. Binding of immunogenic peptides to Ia histocompatibility molecules
5. Transfer of specificity by murine α and β T‐cell receptor genes
6. Specific antigenla activation of transfected human T cells expressing murine Ti αβ‐human T3 receptor complexes
7. Cytotoxic T cells recognize fragments of the influenza nucleoprotein
8. The ins and outs of antigen processing and presentation
9. Antigen presentation: structural themes and functional variations
10. The biochemistry and cell biology of antigen processing and presentation
11. Effect of polymorphism of an MHC‐linked transporter on the peptides assembled in a class‐I molecule
12. Efficient dissociation of the p88 chaperone from major histocompatibility complex class‐I molecules requires both β2‐microglobulin and peptide
13. b molecule
14. Allelespecific motifs revealed by sequencing of self‐peptides eluted from MHC molecules
15. Characterization of peptides bound to the class I MHC molecule HLA‐A2.1 by mass spectrometry
16. Structure of the human class I histocompatibility antigen, HLA‐A2
17. Specificity pockets for the side chains of peptide antigens in HLA‐Aw68
18. Refined structure of the human histocompatibility antigen HLA‐A2 at 2.6 A resolution
19. The structure of HLA‐B27 reveals nonamer self‐peptides bound in an extended conformation
20. b
21. Emerging principles for the recognition of peptide antigens by MHC class I molecules
22. Identification of self peptides bound to purified HLA‐B27
23. H‐2M3 presents a Listeria monocytogenes peptide to cytotoxic T lymphocytes
24. Invariant chain promotes egress of poorly expressed, haplotype‐mismatched class II major histocompatibility complex Aβ dimers from the endoplasmic reticulum/cis‐Golgi compartment
25. Invariant chain influences post‐translational processing of HLA‐DR molecules
26. Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules
27. Mice lacking the MHC class II‐associated invariant chain
28. + T cell selection in mice lacking invariant chain expression
29. Invariant chain association with HLA‐DR molecules inhibits immunogenic peptide binding
30. Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways
31. MHC class II‐associated invariant chain contains a sorting signal for endosomal compartments
32. Intracellular transport of class II MHC molecules directed by invariant chain
33. Relationship between invariant chain expression and MHC Class II transport into early and late endocytic compartments
34. Antigen‐specific interaction between T and B cells
35. Antigen presentation by haptenspecific B lymphocytes. I. Role of surface immunoglobulin receptors
36. Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes
37. Peptide binding inhibits protein aggregation of invariant‐chain free class II dimers and promotes selective cell surface expression of occupied molecules
38. Sequence analysis of peptides bound to MHC class II molecules
39. Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs
40. The predominant naturally processed peptides bound to HLA‐DRI are derived from MHC‐related molecules and are heterogeneous in size
41. d
42. k
43. Promiscuous and allele‐specific anchors in HLA‐DR‐binding peptides
44. The three dimensional structure of the human class II histocompatibility antigen HLA‐DRI
45. The importance of dominant negative effects of amino acid side chain substitutions in peptide‐MHC molecule interactions and T cell recognition
46. Correlation between CD8 dependency and determinant density using peptideinduced, Ld‐restricted cytotoxic T lymphocytes
47. Induction of broadly cross‐reactive cytotoxic T cells recognizing an HIV‐1 envelope determinant
48. Liposome‐encapsulated antigens are processed in lysosomes, recycled, and presented to T cells
49. Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages
50. Vaccinia virus recombinants: expression of VSV genes and protective immunization of mice and cattle
51. Class I restricted CTL recognition of a soluble protein delivered by liposomes containing lipophilic polylysines
52. MHC class II structure, occupancy and surface expression determined by post‐endoplasmic reticulum antigen binding
53. Processed antigen binds to newly synthesized MHC class II molecules in antigen‐specific B lymphocytes
54. In vivo competition between self peptides and foreign antigens in T‐cell activation
55. Processing of liposome‐encapsulated antigens targeted to specific subcellular compartments
56. Targeted antigen presentation using crosslinked antibody heteroaggregates
57. Genetic immunization is a simplemethod for eliciting an immune response
58. Phagocytic processing of bacterial antigens for class I MHC presentation to T cells