Benzophenone- and Indolecarboxylic Acids: Potent Type-2 Specific Inhibitors of Human Steroid 5α-Reductase

Journal of Medicinal Chemistry

Volumn 38, Issue 1, 1995, Pages 13-15

  Holt, Dennis A ^a   Yamashita, Dennis S ^b   Konialian Beck, Arda L ^b   Luengo, Juan I ^b   Abell, Andrew D ^c   Bergsma, Derk J ^b   Brandt, Martin ^b   Levy, Mark A ^b  

^a ARIAD PHARMACEUTICALS INC   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

4 TOLUOYLBENZOPHENONECARBOXYLIC ACID; 5 BENZYLOXY 2 INDOLECARBOXYLIC ACID; ANDROSTANOLONE; BENZOPHENONE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; INDOLE DERIVATIVE; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE INHIBITOR; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHO CELL; CONCENTRATION RESPONSE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; INHIBITION KINETICS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

BENZOPHENONES; CARBOXYLIC ACIDS; HUMAN; INDOLES; OXIDOREDUCTASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0029019724     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00001a004     Document Type: Article

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