17β-estradiol attenuates acetylcholine-induced coronary arterial constriction in women but not men with coronary heart disease

Circulation

Volumn 92, Issue 1, 1995, Pages 24-30

  Collins, Peter ^a,d   Rosano, Giuseppe M C ^a   Sarrel, Philip M ^b   Ulrich, Lian ^c   Adamopoulos, Stamatis ^a   Beale, Carolyn M ^a   McNeill, John G ^a   Poole Wilson, Philip A ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b YALE UNIVERSITY   (United States)

^c NOVO NORDISK A S   (Denmark)

^d NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

arteries; circulation; hormones

Indexed keywords

ACETYLCHOLINE; ESTRADIOL;

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CONSTRICTION; DRUG EFFECT; DRUG SCREENING; FEMALE; HUMAN; INTRACORONARY INFUSION; ISCHEMIC HEART DISEASE; MALE; POSTMENOPAUSE; PRIORITY JOURNAL; SEX DIFFERENCE;

EID: 0029018514     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.92.1.24     Document Type: Article

References (48)

1. Colditz GA, Willett WC, Stampfer MJ, Rosner B, Speizer FE, Hennekens CH. Menopause and the risk of coronary heart disease in women. N Engl J Med. 1987;316:1105-1110.
2. Godsland IF, Wynn V, Crook D, Miller NE. Sex, plasma lipoproteins, and atherosclerosis: prevailing assumptions and outstanding questions. Am Heart J. 1987;114:1467-1503.
3. Bush TL, Barrett-Connor E, Cowan LD, Criqui MH, Wallace RB, Suchindran CM, Tyroler HA, Rifkind BM. Cardiovascular mortality and noncontraceptive use of estrogen in women: results from the Lipid Research Clinics Program Follow-up Study. Circulation. 1987;75:1102-1109.
4. Gruchow HW, Anderson AJ, Barboriak JJ, Sobocinski KA. Post-menopausal use of estrogen and occlusion of coronary arteries. Am Heart J. 1988;115:954-963.
5. Sullivan JM, Vander Zwaag R, Lemp GF, Hughes JP, Maddock V, Kroetz FW, Ramanathan KB, Mirvis DM. Postmenopausal estrogen use and coronary atherosclerosis. Ann Intern Med. 1988; 108:358-363.
6. Stampfer MJ, Colditz GA, Willett WC, Manson JE, Rosner B, Speizer FE, Hennekens CH. Postmenopausal estrogen therapy and cardiovascular disease. N Engl J Med. 1991;325:756-762.
7. Sarrel PM. Ovarian hormones and the circulation. Maturitas. 1990;12:287-298.
8. Knopp RH. The effects of postmenopausal estrogen therapy on the incidence of arteriosclerotic vascular disease. Obstet Gynecol. 1988;72:23S-30S.
9. Bush TL, Fried LP, Barrett-Connor E. Cholesterol, lipoproteins, and coronary heart disease in women. Clin Chem. 1988;34:B60-B70.
10. Barrett-Connor E, Bush TL. Estrogen and coronary heart disease in women. JAMA. 1991;265:1861-1867.
11. Adams MR, Kaplan JR, Manuck SB, Koritnik DR, Parks JS, Wolfe MS, Clarkson TB. Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys: lack of an effect of added progesterone. Arteriosclerosis. 1990;10:1051-1057.
12. Collins P, Rosano GMC, Jiang C, Lindsay D, Sarrel PM, Poole-Wilson PA. Hypothesis: cardiovascular protection by oestrogen: a calcium antagonist effect? Lancet. 1993;341:1264-1265.
13. Gisclard V, Miller VM, Vanhoutte PM. Effect of 17β-estradiol on endothelium-dependent responses in the rabbit. J Pharmacol Exp Ther. 1988;244:19-22.
14. Hayashi T, Fukuto JM, Ignarro LJ, Chaudhuri G. Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. Proc Natl Acad Sci U S A. 1992;89:11259-11263.
15. Van Buren G, Yang D, Clark KE. Estrogen-induced uterine vaso-dilatation is antagonized by L-nitroarginine methyl ester, an inhibitor of nitric oxide synthesis. Am J Obstet Gynecol. 1992;16: 828-833.
16. Polderman KH, Stehouwer CDA, van Kamp GJ, Dekker GA, Verheugt FWA, Gooren LJG. Influence of sex hormones on plasma endothelin levels. Ann Intern Med. 1993;118:429-432.
17. Magness RR, Rosenfeld CR. Local and systemic estradiol-17 beta: effects on uterine and systemic vasodilation. Am J Physiol. 1989;256:E536-E542.
18. Volterrani M, Rosano GMC, Coats A, Beale C, Collins P. Estrogen acutely increases peripheral blood flow in postmenopausal women. Am J Med. In press.
19. Jiang C, Sarrel PM, Lindsay DC, Poole-Wilson PA, Collins P. Endothelium-independent relaxation of rabbit coronary artery by 17β-oestradiol in vitro. Br J Pharmacol. 1991;104:1033-1037.
20. Jiang C, Sarrel PM, Poole-Wilson PA, Collins P. Acute effect of 17β-estradiol on rabbit coronary artery contractile responses to endothelin-1. Am J Physiol. 1992;263:H271-H275.
21. 2+ in guinea-pig isolated cardiac myocytes. Br J Pharmacol. 1992;106:739-745.
22. Williams JK, Adams MR, Herrington DM, Clarkson TB. Short-term administration of estrogen and vascular responses of atherosclerotic coronary arteries. J Am Coll Cardiol. 1992;20:452-457.
23. Reis SE, Gloth ST, Blumenthal RS, Resar JR, Zacur HA, Gerstenblith G, Brinker JA. Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in post-menopausal women. Circulation. 1994;89:52-60.
24. Rosano GMC, Sarrel PM, Poole-Wilson PA, Collins P. Beneficial effect of oestrogen on exercise-induced myocardial ischaemia in women with coronary artery disease. Lancet. 1993;342:133-136.
25. Wallenstein S, Zucker CL, Fleiss JL. Some statistical methods useful in circulation research. Circ Res. 1980;47:1-9.
26. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288:373-376.
27. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987;327:524-526.
28. Collins P, Burman J, Chung H, Fox KM. Hemoglobin inhibits endothelium-dependent relaxation to acetylcholine in human coronary arteries in vivo. Circulation. 1993;87:80-85.
29. Myers PR, Minor RL Jr, Guerra R Jr, Bates JN, Harrison DG. Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature. 1990;345:161-163.
30. Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, Ganz P. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 1986;315:1046-1051.
31. Vita JA, Treasure CB, Yeung AC, Vekshtein VI, Fantasia GM, Fish RD, Ganz P, Selwyn AP. Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrate marked increase in sensitivity to constrictor effects of catecholamines. Circulation. 1992;85:1390-1397.
32. Yeung AC, Vekshtein VI, Krantz DS, Vita JA, Ryan TJ Jr, Ganz P, Selwyn AP. The effect of atherosclerosis on the vasomotor response of coronary arteries to mental stress. N Engl J Med. 1991;325: 1551-1556.
33. Horio Y, Yasue H, Okumura K, Takaoka K, Matsuyama K, Goto K, Minoda K. Effects of intracoronary injection of acetylcholine on coronary arterial hemodynamics and diameter. Am J Cardiol. 1988;62:887-891.
34. Egashira K, Inou T, Hirooka Y, Yamada A, Urabe Y, Takeshita A. Evidence of impaired endothelium-dependent coronary vasodilatation in patients with angina pectoris and normal coronary angiograms. N Engl J Med. 1993;328:1659-1664.
35. Egashira K, Inou T, Hirooka Y, Kai H, Sugimachi M, Suzuki S, Kuga T, Urabe Y, Takeshita A. Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation. 1993;88:77-81.
36. Williams JK, Adams MR, Klopfenstein HS. Estrogen modulates responses of atherosclerotic coronary arteries. Circulation. 1990;81:1680-1687.
37. Simon BC, Cunningham LD, Cohen RA. Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery. J Clin Invest. 1990;86:75-79.
38. Jiang C, Jacobs M, Kerr P, Collins P. Oxidised low density lipoproteins (OxLDL) inhibit endothelium-dependent relaxation to acetylcholine (ACh) in isolated rabbit coronary arteries. J Am Coll Cardiol. 1993;21:430A. Abstract.
39. Minor RL Jr, Myers PR, Guerra R Jr, Bates JN, Harrison DG. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest. 1990;86:2109-2116.
40. Yagi K, Komura S. Inhibitory effect of female hormones on lipid peroxidation. Biochem Int. 1986;13:1051-1055.
41. Creager MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J, Dzau VJ. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest. 1990;86:228-234.
42. Shay J, Badrov N, Attele A, Levinson M, Moss J. Estrogen antagonises endothelin-1 vasoconstriction in rabbit basilar artery. Anesth Analg. 1993;A561. Abstract.
43. Lerman A, Webster MWI, Chesebro JH, Edwards WD, Wei C-M, Fuster V, Burnett JC Jr. Circulating and tissue endothelin immunoreactivity in hypercholesterolemic pigs. Circulation. 1993;88: 2923-2928.
44. Gilligan DM, Quyyumi AA, Cannon RO III. Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation. 1994;89:2545-2551.
45. Collins P, Shay J, Jiang C, Moss J. Nitric oxide accounts for dose-dependent estrogen-mediated coronary relaxation following acute estrogen withdrawal. Circulation. 1994;90:1964-1968.
46. Schray-Utz B, Zeiher AM, Busse R. Expression of constitutive NO synthase in cultured endothelial cells is enhanced by 17β-estradiol. Circulation. 1993;88(suppl I):I-80. Abstract.
47. Sayegh HS, Ohara Y, Navas JP, Peterson TE, Dockery S, Harrison DG. Endothelial nitric oxide synthase regulation by estrogens. Circulation. 1993;88(suppl I):I-80. Abstract.
48. Weiner CP, Lizasoain I, Baylis SA, Knowles RG, Charles IG, Moncada S. Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci U S A. 1994;91:5212-5216.