Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 4. Identification of an Inhibitor with an Intermediate Duration of Action

Journal of Medicinal Chemistry

Volumn 38, Issue 14, 1995, Pages 2748-2762

  Leach, Colin A ^a   Brown, Thomas H ^a   Ife, Robert J ^a   Keeling, David J ^b   Parsons, Michael E ^c   Theobald, Colin J ^a   Wiggall, Kenneth J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

^c UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 BUTYRYL 4 [(2 METHYLPHENYL)AMINO] 8 (2 HYDROXYETHOXY)QUINOLINE; 3 BUTYRYL 8 (2 HYDROXYETHOXY) 4 (2 METHYLANILINO)QUINOLINE; 3 BUTYRYL 8 METHOXY 4 (2 METHYLANILINO)QUINOLINE; CIMETIDINE; ENZYME INHIBITOR; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; OMEPRAZOLE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; QUINOLINE DERIVATIVE; STOMACH SECRETION INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DOG; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; DRUG TOLERANCE; INTRAVENOUS DRUG ADMINISTRATION; MEMBRANE VESICLE; NONHUMAN; ORAL DRUG ADMINISTRATION; PKA; RAT; STOMACH ACID SECRETION; STOMACH POUCH; STRUCTURE ACTIVITY RELATION;

H(+)-K(+)-EXCHANGING ATPASE; MAGNETIC RESONANCE SPECTROSCOPY; QUINOLINES; STOMACH; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 0029014195     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00014a026     Document Type: Article

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