메뉴 건너뛰기




Volumn 16, Issue 7, 1995, Pages 1449-1454

Tamoxifen and the induction of cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; CARCINOGEN; CYTOCHROME P450; TAMOXIFEN;

EID: 0029012731     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/16.7.1449     Document Type: Review
Times cited : (61)

References (42)
  • 1
    • 0022338828 scopus 로고
    • Consensus conference; Adjuvant chemotherapy for breast cancer
    • Anon, M. (1985) Consensus conference; Adjuvant chemotherapy for breast cancer. J. Am. Med. Assoc., 254, 3461-3463.
    • (1985) J. Am. Med. Assoc. , vol.254 , pp. 3461-3463
    • Anon, M.1
  • 2
    • 0027450031 scopus 로고
    • Hormonal chemo- prevention of cancer in women
    • Henderson, B.E., Ross, R.K. and Pike, M.C. (1992) Hormonal chemo- prevention of cancer in women. Science, 259, 633-638.
    • (1992) Science , vol.259 , pp. 633-638
    • Henderson, B.E.1    Ross, R.K.2    Pike, M.C.3
  • 3
    • 0027527396 scopus 로고
    • Cancer chemoprevention: Principles and prospects
    • Morse, A.M. and Stoner, G.D. (1993) Cancer chemoprevention: principles and prospects. Carcinogenesis, 14, 1737-1746.
    • (1993) Carcinogenesis , vol.14 , pp. 1737-1746
    • Morse, A.M.1    Stoner, G.D.2
  • 4
    • 0027397629 scopus 로고
    • Tamoxifen induces hepatocellular carcinoma in rat liver: A 1-year study with two antiestrogens
    • Hirsimaki, P., Hirsimaki, Y., Nieminen, L. and Payne, B.J. (1993) Tamoxifen induces hepatocellular carcinoma in rat liver: a 1-year study with two antiestrogens. Arch. Toxicol., 67, 49-54.
    • (1993) Arch. Toxicol. , vol.67 , pp. 49-54
    • Hirsimaki, P.1    Hirsimaki, Y.2    Nieminen, L.3    Payne, B.J.4
  • 6
    • 0027201501 scopus 로고
    • Two- year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats
    • Greaves, P., Goonetilleke, R., Nunn, G., Topham, J. and Orton, T. (1993) Two- year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. Cancer Res., 53, 3919-3924.
    • (1993) Cancer Res. , vol.53 , pp. 3919-3924
    • Greaves, P.1    Goonetilleke, R.2    Nunn, G.3    Topham, J.4    Orton, T.5
  • 7
    • 0024259680 scopus 로고
    • Pelvic irradiation and tamoxifen as risk factors for carcinoma of corpus uteri
    • Hardell, L. (1988) Pelvic irradiation and tamoxifen as risk factors for carcinoma of corpus uteri. Lancet, 2, no. 8625, 1432.
    • (1988) Lancet , vol.2 , Issue.8625 , pp. 1432
    • Hardell, L.1
  • 9
    • 0028208456 scopus 로고
    • Endometrial cancer in tamoxifen-treated breast cancer patients: Findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14
    • Fisher, B., Costantino, J.P., Redmond, C.K., Fisher, E.R., Wickerham, D.L. and Cronin, W.M. (1994) Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14. J. Natl. Cancer Inst., 86, 527-537.
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 527-537
    • Fisher, B.1    Costantino, J.P.2    Redmond, C.K.3    Fisher, E.R.4    Wickerham, D.L.5    Cronin, W.M.6
  • 10
    • 0027412216 scopus 로고
    • Highgrade endometrial carcinoma in tamoxifen-treated breast cancer patients
    • Magriples, U., Naftolin, F., Schwartz, P.E. and Carcangiu, M.L. (1993) Highgrade endometrial carcinoma in tamoxifen-treated breast cancer patients. J. Clin. Oncol., 11, 485-490.
    • (1993) J. Clin. Oncol. , vol.11 , pp. 485-490
    • Magriples, U.1    Naftolin, F.2    Schwartz, P.E.3    Carcangiu, M.L.4
  • 14
    • 0026607797 scopus 로고
    • Tamoxifen-associated hepatocellular damage and agranulocytosis
    • Ching, C.K., Smith, P.G. and Long, R.G. (1992) Tamoxifen-associated hepatocellular damage and agranulocytosis. Lancet, 339, 940.
    • (1992) Lancet , vol.339 , pp. 940
    • Ching, C.K.1    Smith, P.G.2    Long, R.G.3
  • 15
    • 0028210878 scopus 로고
    • DNA adduct formation by tamoxifen with rat and human liver microsomal activation systems
    • Pathak, D.N. and Bodell, W.J. (1994) DNA adduct formation by tamoxifen with rat and human liver microsomal activation systems. Carcinogenesis, 15, 529-532.
    • (1994) Carcinogenesis , vol.15 , pp. 529-532
    • Pathak, D.N.1    Bodell, W.J.2
  • 16
    • 0027325734 scopus 로고
    • Cardiac and thromboembolic morbidity among postmenopausal women with early-state breast cancer in a randomized trial of adjuvant tamoxifen
    • Rutqvist, L.E. and Mattsson, A. (1993) Cardiac and thromboembolic morbidity among postmenopausal women with early-state breast cancer in a randomized trial of adjuvant tamoxifen. J. Natl Cancer Inst., 85, 1398-1406.
    • (1993) J. Natl Cancer Inst. , vol.85 , pp. 1398-1406
    • Rutqvist, L.E.1    Mattsson, A.2
  • 17
    • 0028107893 scopus 로고
    • Fatal neutropenia associated with long-term tamoxifen therapy
    • Mike, V., Currie, V.E. and Gee, T.S. (1994) Fatal neutropenia associated with long-term tamoxifen therapy. Lancet, 344, 541.
    • (1994) Lancet , vol.344 , pp. 541
    • Mike, V.1    Currie, V.E.2    Gee, T.S.3
  • 19
    • 0023034379 scopus 로고
    • Effects of ethinyl estradiol and tamoxifen on liver DNA turnover and new synthesis and appearance of gamma glutamyl transpeptidase-positive foci in female rats
    • Yager, J.D., Roebuck, B.D., Paluszcyk, T.L. and Memoli, V.A. (1986) Effects of ethinyl estradiol and tamoxifen on liver DNA turnover and new synthesis and appearance of gamma glutamyl transpeptidase-positive foci in female rats. Carcinogenesis. 7, 2007-2014.
    • (1986) Carcinogenesis , vol.7 , pp. 2007-2014
    • Yager, J.D.1    Roebuck, B.D.2    Paluszcyk, T.L.3    Memoli, V.A.4
  • 20
    • 0026606580 scopus 로고
    • Induction of covalent DNA adducts inrodents by tamoxifen
    • Han, X. and Liehr, J.G. (1992) Induction of covalent DNA adducts inrodents by tamoxifen. Cancer Res., 52, 1360-1363.
    • (1992) Cancer Res. , vol.52 , pp. 1360-1363
    • Han, X.1    Liehr, J.G.2
  • 21
    • 0027054733 scopus 로고
    • Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells
    • White, I.N.H., De Matteis, F., Davies, A., Smith, L.L., Crofton-Sleigh, C., Venitt, S., Hewer, A. and Phillips, D.H. (1992) Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells. Carcinogenesis, 13, 2197-2203.
    • (1992) Carcinogenesis , vol.13 , pp. 2197-2203
    • White, I.N.H.1    De Matteis, F.2    Davies, A.3    Smith, L.L.4    Crofton-Sleigh, C.5    Venitt, S.6    Hewer, A.7    Phillips, D.H.8
  • 22
    • 0028233205 scopus 로고
    • Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female Sprague-Dawley rats
    • Sargent, L.M., Dragan, Y.P., Bahnub, N., Wiley, J.E., Sattler, C.A., Schroeder, P, Sattler, G.L., Jordan, V.C. and Pitot, H.C. (1994) Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female Sprague-Dawley rats. Cancer Res., 54, 3357-3360.
    • (1994) Cancer Res. , vol.54 , pp. 3357-3360
    • Sargent, L.M.1    Dragan, Y.P.2    Bahnub, N.3    Wiley, J.E.4    Sattler, C.A.5    Schroeder, P.6    Sattler, G.L.7    Jordan, V.C.8    Pitot, H.C.9
  • 23
    • 0027930072 scopus 로고
    • Frequent and specific mutations of the rat pS3 gene in hepatocarcinomas induced by tamoxifen
    • Vancutsem, P.M., Lazarus, P. and Williams, G.M. (1994) Frequent and specific mutations of the rat pS3 gene in hepatocarcinomas induced by tamoxifen. Cancer Res., 54, 3864-3867.
    • (1994) Cancer Res. , vol.54 , pp. 3864-3867
    • Vancutsem, P.M.1    Lazarus, P.2    Williams, G.M.3
  • 25
    • 0026575696 scopus 로고
    • Role of tamoxifen in the induction of hormone-independent rat mammary tumors
    • Fendl, K.C. and Zimniski, S.J. (1992) Role of tamoxifen in the induction of hormone-independent rat mammary tumors. Cancer Res., 52, 235-237.
    • (1992) Cancer Res. , vol.52 , pp. 235-237
    • Fendl, K.C.1    Zimniski, S.J.2
  • 26
    • 0015225140 scopus 로고
    • Adenocarcinoma of the vagina: Association of maternal stilbestrol therapy with tumor appearance in young women
    • Herbst, A.L., Ulfelder, H. and Poskanzer, D.C. (1971) Adenocarcinoma of the vagina: association of maternal stilbestrol therapy with tumor appearance in young women. New Engl. J. Med., 284, 878-881.
    • (1971) New Engl. J. Med. , vol.284 , pp. 878-881
    • Herbst, A.L.1    Ulfelder, H.2    Poskanzer, D.C.3
  • 27
    • 0038351753 scopus 로고
    • Monographs on the Evaluation of Carcinogenic Risks to Humans
    • ARC, Vols 1-42. I ARC, Lyon
    • ARC (1987) Monographs on the Evaluation of Carcinogenic Risks to Humans. Overall Evaluation of Carcinogenicity: An Updating of I ARC Monographs Vols 1-42. I ARC, Lyon, pp. 272-310.
    • (1987) Overall Evaluation of Carcinogenicity: An Updating of I ARC Monographs , pp. 272-310
  • 28
    • 0025373464 scopus 로고
    • Genotoxic effects of estrogens
    • Liehr, J.G. (1990) Genotoxic effects of estrogens. Mutât. Res., 238, 269-276.
    • (1990) Mutât. Res. , vol.238 , pp. 269-276
    • Liehr, J.G.1
  • 29
    • 0027350669 scopus 로고
    • Phillips, D.H., Castegnaro, M. and Bartsch, H. (eds). Postlabelling Methods for Detection of DNA Adducts. IARC, Lyon
    • Liehr, J.G., Han, X. and Bhat, H.K. (1993) 32P-Postlabelling in studies of hormonal carcinogenesis. In Phillips, D.H., Castegnaro, M. and Bartsch, H. (eds). Postlabelling Methods for Detection of DNA Adducts. IARC, Lyon, pp. 149-155.
    • (1993) 32P-Postlabelling in Studies of Hormonal Carcinogenesis , pp. 149-155
    • Liehr, J.G.1    Han, X.2    Bhat, H.K.3
  • 30
    • 0028263871 scopus 로고
    • Alterations of drug metabolizing and antioxidant enzyme activities during tamoxifen- induced hepatocarcinogenesis
    • Ahotupa, M., Hirsimaki, P., Parssinen, R. and Mantyla, E. (1994) Alterations of drug metabolizing and antioxidant enzyme activities during tamoxifen- induced hepatocarcinogenesis. Carcinogenesis, 15, 863-868.
    • (1994) Carcinogenesis , vol.15 , pp. 863-868
    • Ahotupa, M.1    Hirsimaki, P.2    Parssinen, R.3    Mantyla, E.4
  • 31
    • 0028035492 scopus 로고
    • Genotoxicity of tamoxifen, tamoxifen epoxide and loremifene in human lymphoblastoid cells containing human cytochrome P450s
    • Styles, J.A., Davies, A., Lim, C.K., De Matteis, F., Stanley, L.A., White, I.N.H., Yuan, Z.-X. and Smith, L.L. (1994) Genotoxicity of tamoxifen, tamoxifen epoxide and loremifene in human lymphoblastoid cells containing human cytochrome P450s. Carcinogenesis, 15, 5-9.
    • (1994) Carcinogenesis , vol.15 , pp. 5-9
    • Styles, J.A.1    Davies, A.2    Lim, C.K.3    De Matteis, F.4    Stanley, L.A.5    White, I.N.H.6    Yuan, Z.-X.7    Smith, L.L.8
  • 32
    • 0028179723 scopus 로고
    • Cochromatography of a tamoxifen epoxide-deoxyguanylic acid adduct with a major DNA adduct formed in the livers of tamoxifen-treated rats
    • Phillips, D.H., Hewer, A., White, I.N.H. and Farmer, P.B. (1994) Cochromatography of a tamoxifen epoxide-deoxyguanylic acid adduct with a major DNA adduct formed in the livers of tamoxifen-treated rats. Carcinogenesis, 15, 793-795.
    • (1994) Carcinogenesis , vol.15 , pp. 793-795
    • Phillips, D.H.1    Hewer, A.2    White, I.N.H.3    Farmer, P.B.4
  • 33
    • 0028326053 scopus 로고
    • A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism
    • Potter, G.A., McCague, R. and Jarman, M. (1994) A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism. Carcinogenesis, 15, 439-442.
    • (1994) Carcinogenesis , vol.15 , pp. 439-442
    • Potter, G.A.1    McCague, R.2    Jarman, M.3
  • 34
    • 0028168009 scopus 로고
    • Reduced genotoxicity of |D5-ethyl|-tamoxifen implicates a-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen
    • Phillips, D.H., Potter, G.A., Horton, M.N., Hewer, A., Crofton-Sleigh, C., Jarman, M. and Venitt, S. (1994) Reduced genotoxicity of |D5-ethyl|-tamoxifen implicates a-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen. Carcinogenesis, 15, 1487-1492.
    • (1994) Carcinogenesis , vol.15 , pp. 1487-1492
    • Phillips, D.H.1    Potter, G.A.2    Horton, M.N.3    Hewer, A.4    Crofton-Sleigh, C.5    Jarman, M.6    Venitt, S.7
  • 35
    • 0028172242 scopus 로고
    • A-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes
    • Phillips, D.H., Carmichael, P.L., Hewer, A., Cole, K.J. and Poon, G.K. (1995) a-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes. Cancer Res., 54, 5518-5522.
    • (1995) Cancer Res. , vol.54 , pp. 5518-5522
    • Phillips, D.H.1    Carmichael, P.L.2    Hewer, A.3    Cole, K.J.4    Poon, G.K.5
  • 36
    • 0028893809 scopus 로고
    • Microsomal and peroxidase activation of 4-hydroxy-tamoxifen to form DNA adducts: Comparison with DNA adducts formed in Sprague-Dawley rats treated with tamoxifen
    • Pathak, D.N., Pongracz, K. and Bodell, W.J. (1995) Microsomal and peroxidase activation of 4-hydroxy-tamoxifen to form DNA adducts: comparison with DNA adducts formed in Sprague-Dawley rats treated with tamoxifen. Carcinogenesis, 16, 11-15.
    • (1995) Carcinogenesis , vol.16 , pp. 11-15
    • Pathak, D.N.1    Pongracz, K.2    Bodell, W.J.3
  • 37
    • 0028226088 scopus 로고
    • Strong intensification of mouse hepatic tamoxifen DNA adduct formation by pretreatment with the sulfotransferase inhibitor ! and ubiquitous environmental pollutant pentachlorophenol
    • Randerath, K., Bi, J., Mabon, N., Sriram, P. and Moorthy, B. (1994) Strong intensification of mouse hepatic tamoxifen DNA adduct formation by pretreatment with the sulfotransferase inhibitor ! and ubiquitous environmental pollutant pentachlorophenol. Carcinogenesis, 15, 797-800.
    • (1994) Carcinogenesis , vol.15 , pp. 797-800
    • Randerath, K.1    Bi, J.2    Mabon, N.3    Sriram, P.4    Moorthy, B.5
  • 38
    • 0028172454 scopus 로고
    • Tamoxifen: Evidence by 32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite
    • Randerath, K., Moorthy, B., Mabon, N. and Sriram, P. (1994) Tamoxifen: evidence by 32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite. Carcinogenesis, 15, 2087-2094.
    • (1994) Carcinogenesis , vol.15 , pp. 2087-2094
    • Randerath, K.1    Moorthy, B.2    Mabon, N.3    Sriram, P.4
  • 39
    • 0017853462 scopus 로고
    • Biochemical charaeteri/aiion of stage ol hepatocarcinogenesis after a single doseot
    • Pitot, MC., Rareness, I, Doldsworthy, T and Kitagawa, I. (1978) Biochemical charaeteri/aiion of stage ol hepatocarcinogenesis after a single doseot diethylmtiosamme A'atute. 271, 456-458
    • (1978) Diethylmtiosamme A'atute , vol.271 , pp. 456-458
    • Pitot, M.C.1    Rareness, I.2    Doldsworthy, T.3    Kitagawa, I.4
  • 41
    • 12644313085 scopus 로고
    • Studies ol carcinogenicity in the rat ol denvatives ol aromatic amines related to iV-2-lluorenylacetamide
    • Moms, H P, Velat, CA., Wagner, BP., Dahlgaid, M. and Ray, FE. (1960) Studies ol carcinogenicity in the rat ol denvatives ol aromatic amines related to iV-2-lluorenylacetamide J Natl Cancer lnt. 24. 149-180.
    • (1960) J Natl Cancer Lnt , vol.24 , pp. 149-180
    • Moms, H.P.1    Velat, C.A.2    Wagner, B.P.3    Dahlgaid, M.4    Ray, F.E.5
  • 42
    • 0022840183 scopus 로고
    • Induction ol prostate carcinoma in wtu at high incidence in F544 rats by a combination ol 5 2’-dimethyl-4-ammohiphcnyl and ethinyl estradiol
    • Shirai, T., Fukushima, S., Ikawa, F., Tagawa, A. and Ito, N. (1986) Induction ol prostate carcinoma in wtu at high incidence in F544 rats by a combination ol 5.2’-dimethyl-4-ammohiphcnyl and ethinyl estradiol Canm Res. 46. 6425-6426.
    • (1986) Canm Res. , vol.46 , pp. 6425-6426
    • Shirai, T.1    Fukushima, S.2    Ikawa, F.3    Tagawa, A.4    Ito, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.