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1
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0027476024
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A synaptic model of memory: long-term potentiation in the hippocampus
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(1993)
Nature
, vol.361
, pp. 31-39
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-
Bliss1
Collingridge2
-
2
-
-
0027938848
-
Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity
-
of special interest, General review on recently discovered physiological roles of mGluRs, with a special emphasis on the role of mGluR6 in the retina, the role of mGluR2 in the accessory olfactory bulb and olfactory memory, and the role of mGluR1 in cerebellar LTD.
-
(1994)
Neuron
, vol.13
, pp. 1031-1037
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-
Nakanishi1
-
3
-
-
0028912822
-
The metabotropic glutamate receptors: structure and functions
-
of special interest, Exhaustive review on the discovery, structure, transduction mechanisms and physiological roles of mGluRs.
-
(1995)
Neuropharmacology
, vol.34
, pp. 1-26
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-
Pin1
Duvoisin2
-
6
-
-
0027955170
-
Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction.
-
of special interest, Cloning of mGluR7, a receptor negatively coupled to adenylyl cyclase with a surprisingly low apparent affinity for l-AP4, l-SOP and glutamate. This receptor is widely distributed in the brain, with higher expression in the cerebral cortex, thalamus, hippocampus, olfactory bulb and colliculi.
-
(1994)
J Biol Chem
, vol.269
, pp. 1231-1236
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-
Okamoto1
Hori2
Akazawa3
Hayashi4
Shigemoto5
Mizuno6
Nakanishi7
-
7
-
-
0028968702
-
A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb
-
of special interest, Cloning of the mouse mGluR8, an mGluR negatively coupled to adenylyl cyclase and activated by l-AP4 that is widely distributed in the brain.
-
(1995)
J Neurosci
, vol.15
, pp. 3075-3083
-
-
Duvoisin1
Zhang2
Ramonell3
-
8
-
-
0028207306
-
Cloning an expression of a new member of the l-2-amino-4-phosphonobutyric acid-class of metabotropic glutamate receptors
-
of special interest, Cloning of mGluR7. Same results as those reported by Okamoto et al. [6]. No antagonistic effects of MCPG was observed.
-
(1994)
Mol Pharmacol
, vol.45
, pp. 367-372
-
-
Saugstad1
Kinzie2
Mulvihill3
Segerson4
Westbrook5
-
9
-
-
0027992583
-
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors
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of special interest, A comprehensive review on the different effects of phenylglycine derivatives, which are competitive antagonists for mGluRs.
-
(1994)
Trends Neurosci
, vol.15
, pp. 333-342
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-
Watkins1
Collingridge2
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10
-
-
0028350739
-
Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes
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of special interest, A complete analysis of the effect of various phenylglycine derivatives on cloned mGluR subtypes.
-
(1994)
J Neurosci
, vol.14
, pp. 3370-3377
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-
Hayashi1
Sekiyama2
Nakanishi3
Jane4
Sunter5
Birse6
Udvarhelyi7
Watkins8
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12
-
-
0029043591
-
Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1
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(1995)
J Neurosci
, vol.15
, pp. 3970-3981
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-
Joly1
Gomeza2
Brabet3
Curry4
Bockaert5
Pin6
-
13
-
-
0028245013
-
Actions of two new antagonists showing selectivity for different subtypes of metabotropic glutamate receptor in the neonatal rat spinal cord
-
(1994)
Br J Pharmacol
, vol.112
, pp. 809-816
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-
Jane1
Jones2
Pook3
Tse4
Watkins5
-
14
-
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0027295942
-
The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins
-
of outstanding interest, The amino-terminal extracellular domain of mGluR1 is shown to share sequence homology with the bacterial periplasmic protein family. A model for the glutamate-binding site of mGluR1 was proposed, and used to identify two residues that play a critical role in the binding of glutamate. This paper also suggested that similar structural domains may be responsible for agonist binding in ionotropic glutamate receptor subunits.
-
(1993)
Neuron
, vol.11
, pp. 41-52
-
-
O'Hara1
Sheppard2
Thøgersen3
Venezia4
Haldeman5
McGrane6
Houamed7
Thomsen8
Gilbert9
Mulvihill10
-
17
-
-
0027787680
-
2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
-
2+-sensing receptor gene are characterized in patients with familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. One of these mutations is found in the third intracellular loop of the receptor and generates an apparently inactive receptor.
-
(1993)
Cell
, vol.75
, pp. 1297-1303
-
-
Pollak1
Brown2
Chou3
Hebert4
Marx5
Steinmann6
Levi7
Seidman8
Seidman9
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18
-
-
0028596211
-
N-Glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1
-
(1994)
Neuron
, vol.13
, pp. 1331-1343
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-
Hollmann1
Maron2
Heinemann3
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19
-
-
0028819612
-
Topology profile for a glutamate receptor: three transmembrane domains and a channel-lining reentrant membrane loop
-
(1995)
Neuron
, vol.14
, pp. 373-383
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-
Bennett1
Dingledine2
-
20
-
-
0028559605
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Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins
-
of outstanding interest, By constructing chimeric receptors from the AMPA receptor subunit GluR3 and the kainate receptor subunit GluR6, these authors show that the agonist selectivity of these subunits is determined by two domains separated by what was initially proposed as three transmembrane domains. A new model for the topology of the subunit with only three transmembrane domains is proposed. A model for the tertiary structure of the glutamate-binding site based on its homology with bacterial periplasmic proteins is presented.
-
(1994)
Neuron
, vol.13
, pp. 1345-1357
-
-
Stern-Bach1
Bettler2
Hartley3
Sheppard4
O'Hara5
Heinemann6
-
21
-
-
0028284469
-
Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins
-
of special interest, Based on the characterization of the residues involved in the glycine-binding site of the glycine receptor subunits, point mutations affecting the glycine binding to the NMDA-R1 subunit are described. This is the first study to support the proposal of O'Hara et al. [14] that the agonist-binding sites in glutamate receptor subunits may be homologous to the bacterial periplasmic proteins. A model for the glycine-binding site in the NMDA-R1 subunit is proposed.
-
(1994)
Neuron
, vol.12
, pp. 1291-1300
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-
Kuryatov1
Laube2
Betz3
Kuhse4
-
22
-
-
0028012253
-
Domains involved in the specificity of G protein activation in phospholipase C coupled metabotropic glutamate receptor
-
of special interest, By constructing chimeric receptors from the adenylyl cyclase coupled mGluR3 and the PLC-coupled mGluR1, the regions involved in the specific coupling to PLC in mGluR1 were identified.
-
(1994)
EMBO J
, vol.13
, pp. 342-348
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-
Pin1
Joly2
Heinemann3
Bockaert4
-
23
-
-
0026168057
-
G proteins and G-protein-coupled receptors: structure, function and interactions
-
(1991)
Curr Opin Neurobiol
, vol.1
, pp. 32-42
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-
Bockaert1
-
24
-
-
0025716317
-
Atomic structures of periplasmic binding proteins and the high-affinity active transport systems in bacteria
-
(1990)
Philos Trans R Soc Lond [Biol]
, vol.326
, pp. 341-351
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-
Quiocho1
-
27
-
-
0027475709
-
Differential localization of phosphoinositide-linked metabotropic glutamate receptor (mGluR1) and the inositol 1,4,5-triphosphate receptor in rat brain
-
of special interest, Using Western blots and an antibody against the amino-terminal domain of mGluR1 (which reacts with all mGluR1 splice variants), the authors show that the major mGluR1 form in the striatum is a short form, either mGluR1b or mGluR1c. Electron microscopy detection of the protein in the striatum revealed labeling of nerve terminals, in contrast to what has been described with an antibody specific for the long-form mGluR1 splice variant, mGluR1a (see Baude et al. [44]).
-
(1993)
J Neurosci
, vol.13
, pp. 2001-2012
-
-
Fotuhi1
Sharp2
Glatt3
Hwang4
Von Krosigk5
Snyder6
Dawson7
-
29
-
-
0026659344
-
l-AP4 inhibits calcium currents and synaptic transmission via a G-protein-coupled glutamate receptor
-
(1992)
J Neurosci
, vol.12
, pp. 2043-2050
-
-
Trombley1
Westbrook2
-
30
-
-
0028218968
-
Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells
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of special interest, An immunocytochemical and immunoelectron microscopy study showing the restricted localization of mGluR6 at the postsynaptic site of the rat rod bipolar cell. This specialization is developmentally regulated; mGluR6 is initially distributed in both the soma and dendrites, and is finally concentrated on the postsynaptic site.
-
(1994)
Cell
, vol.77
, pp. 361-369
-
-
Nomura1
Shigemoto2
Nakamura3
Okamoto4
Mizuno5
Nakanishi6
-
31
-
-
0027232329
-
Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for l-2-amino-4-phosphonobutyrate
-
of special interest, Cloning of a retina-specific mGluR, mGluR6, that is activated by l-AP4 and l-SOP and that inhibits cAMP formation.
-
(1993)
J Biol Chem
, vol.268
, pp. 11868-11873
-
-
Nakajima1
Iwakabe2
Akazawa3
Nawa4
Shigemoto5
Mizuno6
Nakanishi7
-
32
-
-
0028036657
-
The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells
-
(1994)
J Neurosci
, vol.14
, pp. 7067-7076
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-
Chavis1
Shinozaki2
Bockaert3
Fagni4
-
33
-
-
0027732539
-
Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb
-
of outstanding interest, Electron microscopy localization of mGluR2 revealed a localization of this receptor at dendrodendritic synapses between granule cells and mitral cells in the accessory olfactory bulb. Using DCG-IV, which is shown to be a high-affinity agonist at mGluR2, the authors revealed that mGluR2 depressed the GABA-mediated inhibitory postsynaptic current on mitral cells.
-
(1993)
Nature
, vol.366
, pp. 687-690
-
-
Hayashi1
Momiyama2
Takahashi3
Ohishi4
Ogawa-Meguro5
Shigemoto6
Mizuno7
Nakanishi8
-
34
-
-
0028088017
-
Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex
-
of special interest, Immunoreactivity to mGluR2 and mGluR3 is shown to be present in cell bodies, dendrites and axon terminals of Golgi cells, as well as in presumed glial processes. Golgi axon terminals with mGluR2/3 immunoreactivity were often encountered in the vicinity of glutamatergic mossy fiber terminals. It is proposed that glutamate released from mossy fibers during strong synaptic activity may diffuse into the intercellular space and reach the Golgi axon terminals, probably depressing the synaptic transmission at these synapses.
-
(1994)
Neuron
, vol.13
, pp. 55-66
-
-
Ohishi1
Ogawa-Meguro2
Shigemoto3
Kaneko4
Nakanishi5
Mizuno6
-
35
-
-
0028850892
-
Metabotropic glutamate receptor (mGluR)-mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR
-
(1995)
J Neurochem
, vol.64
, pp. 592-599
-
-
Winder1
Conn2
-
36
-
-
0028362318
-
Potentiation of cAMP responses by metabotropic glutamate receptors depresses excitatory synaptic transmission by a kinase-independent mechanism
-
(1994)
Neuron
, vol.12
, pp. 1121-1129
-
-
Gereau1
Conn2
-
37
-
-
0028222023
-
A cyclic AMP-dependent form of associative synaptic plasticity induced by coactivation of beta-adrenergic receptors and metabotropic glutamate receptors in rat hippocampus.
-
(1994)
J Neurosci
, vol.14
, pp. 3310-3318
-
-
Gereau1
Conn2
-
38
-
-
0028108923
-
CREB: a mediator of long-term memory from mollusks to mammals
-
(1994)
Cell
, vol.79
, pp. 5-8
-
-
Frank1
Greenberg2
-
39
-
-
0026564333
-
Inhibition of calcium channels in rat CA3 pyramidal neurons by a metabotropic glutamate receptor
-
(1992)
J Neurosci
, vol.12
, pp. 4358-4371
-
-
Swartz1
Bean2
-
43
-
-
0029002053
-
Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain
-
of special interest, Immunolocalization of mGluR5. Electron microscopy studies revealed the presence of mGluR5 at the postsynaptic site. Some axon terminals were also labeled, indicating that mGluR5 may also be presynaptically localized.
-
(1995)
J Comp Neurol
-
-
Romano1
Sesma2
MacDonald3
O'Malley4
Van den Pol5
Olney6
-
44
-
-
0027520283
-
The metabotropic glutamate receptor (mGluR1α) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction
-
of outstanding interest, Using a specific antibody and electron microscopic immunometal detection, mGluR1α is shown to be localized at the periphery of postsynaptic densities of type I synapses in both the cerebellum and the hippocampus. No immunoreactivity is observed in axon terminals.
-
(1993)
Neuron
, vol.11
, pp. 771-787
-
-
Baude1
Nusser2
Roberts3
Mulvihill4
McIlhinney5
Somogyi6
-
46
-
-
0028310856
-
Activation of metabotropic glutamate receptors differentially affects two classes of hippocampal interneurons and potentiates excitatory synaptic transmission
-
of special interest, First electrophysiological evidence for a presynaptic potentiation induced by mGluR agonists.
-
(1994)
J Neurosci
, vol.14
, pp. 4433-4445
-
-
McBain1
Dichiara2
Kauer3
-
48
-
-
0027967167
-
Induction of an olfactory memory by the activation of a metabotropic glutamate receptor
-
of outstanding interest, Female mice memorize the male pheromone at mating, and exposure of the pregnant mice to a different male pheromone evokes pregnancy block. This olfactory memory, known as the ‘Bruce effect’, results from a sustained enhancement of norepinephrine release after mating, which inhibits GABA release from granule cells in the accessory olfactory bulb (AOB). Because activation of mGluR2 also leads to a depression of the GABA inhibitory postsynaptic current at these synapses (see Hayashi et al. [33]), the effect of specific mGluR2 agonists directly applied in the AOB on the ‘Bruce effect’ was examined. This was shown to favour the memorization of male pheromones without mating.
-
(1994)
Science
, vol.265
, pp. 262-264
-
-
Kaba1
Hayashi2
Higuchi3
Nakanishi4
-
49
-
-
0028208421
-
Long-term synaptic depression in the mammalian brain
-
of special interest, Comprehensive review on LTP.
-
(1994)
Neuron
, vol.12
, pp. 457-472
-
-
Linden1
-
50
-
-
0028284466
-
Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells
-
of special interest, A polyclonal antibody directed against the amino-terminal domain of mGluR1 was shown to inhibit the activity of this receptor. This antibody is shown to inhibit the LTD of the AMPA current induced by application of glutamate in conjunction with Purkinje cell depolarization.
-
(1994)
Neuron
, vol.12
, pp. 1245-1255
-
-
Shigemoto1
Abe2
Nomura3
Nakanishi4
Hirano5
-
51
-
-
0027997686
-
Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1
-
of outstanding interest, It is shown that mGluR1 knock-out mice are ataxic, and are impaired in spatial learning capacity, as revealed using the Morris water maze test. Electrophysiological studies revealed no modification in the LTP at the Schaffer collateral—CA1 synapses, but a decrease in the LTP at the mossy fiber—CA3 synapses in the mutant mice. In the cerebellum, a decrease in the LTD at parallel fiber-Purkinje cell synapses is observed.
-
(1994)
Nature
, vol.372
, pp. 237-243
-
-
Conquet1
Bashir2
Davies3
Daniel4
Ferraguti5
Bordi6
Franz-Bacon7
Reggiani8
Matarese9
Condé10
-
52
-
-
0028149789
-
Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
-
2+ currents are normal, no LTD can be induced in the cerebellum of mGluR1 knock-out mice. These mutant mice are ataxic and are impaired in motor coordination and associative learning of eyeblink responses.
-
(1994)
Cell
, vol.79
, pp. 377-388
-
-
Aiba1
Kano2
Chen3
Stanton4
Fox5
Herrup6
Zwingman7
Tonegawa8
-
53
-
-
0026637694
-
Quisqualate metabotropic receptors modulate NMDA currents and facilitate induction of long-term potentiation through protein kinase C
-
(1992)
Eur J Neurosci
, vol.4
, pp. 500-505
-
-
Aniksztejn1
Otani2
Ben-Ari3
-
57
-
-
0028287907
-
A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation
-
of outstanding interest, MCPG is shown to no longer inhibit LTP induction after a first LTP has been induced. It is proposed that MCPG turns on a molecular ‘switch’ that no longer needs to be activated for a second LTP. This mGluR-activated switch is input specific and can be turned off by a train of low frequency stimulation.
-
(1994)
Nature
, vol.368
, pp. 740-743
-
-
Bortolotto1
Bashir2
Davies3
Collingridge4
-
58
-
-
0028082151
-
Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation
-
of outstanding interest, It is shown that tetanic stimulation of the Schaffer collaterals induced a long-lasting potentiation of the NMDA component of the excitatory postsynaptic currents in the CA1 region of the hippocampus. This effect is probably mediated by mGluRs as it is reproduced by ACPD and greatly reduced in the presence of MCPG.
-
(1994)
Nature
, vol.367
, pp. 557-559
-
-
O'Connor1
Rowan2
Anwyl3
-
59
-
-
0028139045
-
Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice
-
2+ current induced by ACPD are not modified in the mutant mice indicating that these effects are mediated by other mGluR subtypes. The mutant mice show a moderate deficit in context-specific associative learning, while performing an associative fear conditioning test.
-
(1994)
Cell
, vol.79
, pp. 365-375
-
-
Aiba1
Chen2
Herrup3
Rosenmund4
Stevens5
Tonegawa6
-
60
-
-
0028181168
-
(R,S)-α-Methyl-4-carboxyphenylglycine (MCPG) blocks spatial learning in rats and long-term potentiation in the dentate gyrus in vivo
-
(1994)
Neurosci Lett
, vol.167
, pp. 141-144
-
-
Riedel1
Wetzel2
Reymann3
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