A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

Neuron

Volumn 14, Issue 5, 1995, Pages 927-939

  Ham, Jonathan ^a   Babij, Carol ^a   Whitfield, Jonathan ^a   Pfarr, Curt M ^b   Lallemand, Dominique ^b   Yaniv, Moshe ^b   Rubin, Lee L ^a  

^a EISAI CO LTD   (Japan)

^b Institut Pasteur   (France)

Author keywords

[No Author keywords available]

Indexed keywords

NERVE GROWTH FACTOR; ONCOPROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; GENE EXPRESSION REGULATION; GROWTH REGULATION; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SYMPATHETIC NERVE; TRANSACTIVATION;

ANIMAL; APOPTOSIS; BASE SEQUENCE; CELLS, CULTURED; GANGLIA, SYMPATHETIC; GENE EXPRESSION; GENES, JUN; MOLECULAR SEQUENCE DATA; MUTATION; NERVE GROWTH FACTORS; NEURONS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0029012476     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/0896-6273(95)90331-3     Document Type: Article

References (78)

1. Redox regulation of Fos and Jun DNA-binding activity in vitro
2. Protein phosphatase 2A potentiates activity of promoters containing AP1-binding elements
3. Rapid transcriptional assay for the expression of two distinct reporter genes by microinjection
4. The jun protooncogene is positively autoregulated by its product, Jun/AP-1
5. The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation
6. Trophic factors and neuronal survival
7. Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction
8. Drosophila Jun mediates Ras-dependent photoreceptor determination
9. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
10. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
11. Mechanism of action of a dominant-negative mutant of c-Jun
12. Overexpression of c-jun, jun B or jun D affects cell growth differently
13. Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90 kDa ribosomal S6 kinase
14. Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun
15. Dangerous liaisons: Fos and Jun, oncogenic transcription factors
16. MAPKs: new JNK expands the group
17. Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor
18. The differential control of c-Jun expression in regenerating sensory neurons and their associated glial cells
19. Jun B differs from c-Jun in its DNA binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers
20. JNK1 a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
21. Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP
22. Comparison of the effects of NGF, activators of protein kinase C, and a calcium ionophore on the expression of Thy-1 and N-CAM in PC12 cell cultures
23. The death programme in cultured sympathetic neurons can be suppressed at the post-translational level by nerve growth factor, cyclic AMP, and depolarization
24. Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal
25. Mechanisms and functions of cell death
26. Altered gene expression in neurons during programmed cell death: identification of c jun as necessary for neuronal apoptosis
27. Induction of apoptosis in fibroblasts by c-myc protein
28. Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter control
29. Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death
30. Prevention of vertebrate neuronal death by the crmA gene
31. Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene
32. Fos family members successively occupy the tyrosine hydroxylase gene AP-1 site after nerve growth factor or epidermal growth factor stimulation and can repress transcription
33. Regulation of the transcription factor c-Jun by nerve growth factor in adult sensory neurons
34. Inducible regulatory elements in the human cyclin D1 promoter
35. Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation
36. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
37. c-Jun is essential for normal mouse development and hepatogenesis
38. Characterization of jun D: a new member of the jun proto-oncogene family
39. Degradation of transcription factors, c-Jun and c-Fos, by calpain
40. Bcl-2 functions in an antioxidant pathway to prevent apoptosis
41. Programmed cell death and Bcl-2 protection in the absence of a nucleus
42. Molecular mechanisms of developmental neuronal death
43. Techniques in the tissue culture of rat sympathetic neurons
44. A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture
45. Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors
46. The neurotrophic factor concept: a reexamination
47. The stress-activated protein kinase subfamily of c-Jun kinases
48. The nerve growth factor 35 years later
49. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77
50. Transformation suppressor activity of a Jun transcription factor lacking its activation domain
51. Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation
52. Apoptosis: suicide, execution, or murder?
53. Motoneurons deprived of trophic support in vitro require new gene expression to undergo programmed cell death
54. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun
55. Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines
56. Cell death during development of the nervous system
57. Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes
58. Mouse Jun-D negatively regulates fibroblast growth and antagonizes transformation by ras
59. Phosphorylation of c-jun mediated by MAP kinases
60. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
61. Social controls on cell survival and cell death
62. Programmed cell death and the control of cell survival: lessons from the nervous system
63. The cell cycle and cell death
64. The molecular mechanisms of neuronal apoptosis
65. Opposite functions of jun-B and c-jun in growth regulation and neuronal differentiation
66. jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun
67. Inhibition of protein synthesis prevents cell death in sensory and parasympathetic neurons deprived of neurotrophic factor in vitro
68. Oncogenic and transcriptional cooperation with Ha-Ras requires phosporylation of c-Jun on serines 63 and 73
69. Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73
70. Continuous c-fos expression precedes programmed cell death in vivo
71. Functions of the neurotrophins during nervous system development: what the knockouts are teaching us
72. Nerve growth factor in mouse and rat serum: correlation between bioassay and radioimmunoassay determinations
73. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the 6 domain
74. Transformation by Fos proteins requires a C-terminal transactivation domain
75. Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas
76. Developmental neuron death in the rat superior cervical sympathetic ganglion: cell counts and ultrastructure
77. p53 and E2F-1 cooperate to mediate apoptosis