Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

Journal of Cellular Physiology

Volumn 163, Issue 3, 1995, Pages 510-522

  Garcia, Joe G N ^a   Davis, Harold W ^a,b   Patterson, Carolyn E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 IODO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; CALCIMYCIN; KT 5926; MYOSIN LIGHT CHAIN; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; PHORBOL ESTER; STAUROSPORINE; THROMBIN; TRIFLUOPERAZINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; COW; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANIMAL; BIOLOGICAL TRANSPORT; CALCIUM; CALMODULIN; CAPILLARY PERMEABILITY; CATTLE; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOTHELIUM, VASCULAR; GAP JUNCTIONS; HUMAN; INTRACELLULAR MEMBRANES; MYOSINS; PHOSPHORYLATION; PROTEIN KINASE C; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TETRADECANOYLPHORBOL ACETATE; THROMBIN;

ANIMALIA;

EID: 0029012398     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.1041630311     Document Type: Article

References (62)

1. The role of phos‐phorylation in regulating contractile proteins
2. Phalloidin enhances endothelial barrier function and reduces inflammatory permeability in vitro
3. Calcium/calmodulin transduces thrombin‐stimulated secretion: Studies in intact and minimally permeabilitzed human umbilical vein endothelial cells
4. Histamine and inositol phosphate accumulation in endothelium: cAMP and a G protein
5. Histamine, actin‐gelsolin binding, and polyphosphoinositides in human umbilical vein endothelial cells
6. Increased phosphorylation of myosin light chain kinase after an increase in cyclic AMP in intact smooth muscle
7. Regulation of thrombin generation and functions
8. Role of phosphorylation in mediating the association of myosin with the cytoskeletal structures of human platelets
9. Molecular mechanisms of thrombin‐induced human and bovine endothelial cell activation
10. Thrombin‐induced increases in albumin clearance across cultured endothelial monolayers
11. Thrombin‐induced prostacyclin biosynthesis in human endothelium: Role of guanine nucleotide regulatory proteins in stimulus/coupling responses
12. Regulation of thrombin‐induced endothelial cell prostaglandin synthesis and barrier function
13. 2+ mobilization, and prostacyclin synthesis in cultured human endothelium: Further evidence for regulation by a pertussis toxin‐insensitive guanine nucleotide‐binding protein
14. Role of protein kinase C in the regulation of prostaglandin synthesis in human endothelium
15. Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3′,5′‐monophosphate
16. 2 synthesis, PDGF mRNA expression, and barrier dysfunction in vascular endothelium
17. Expression of nonmuscle myosin heavy and light chains in smooth muscle
18. Structure and function of endothelial cytoskeleton
19. 2+‐binding protein calmodulin for activity
20. Gelsolinactin interaction and actin polymerization in human neutrophils
21. Effects or neutrophil chemotaxis across human endothelial cell monolayers on the permeability of these monolayers to ions and macromolecules
22. Effects of phosphorylation of light chain residues threonine 18 and serine 19 on the properties and conformation of smooth muscle myosin
23. Diphosphorylation of platelet myosin by myosin light chain kinase
24. Thrombin and histamine rapidly stimulate the phosphorylation of the myristoylated alanine‐rich C‐kinase substrate in human umbilical vein endothelial cells: Evidence for distinct patterns of protein kinase activation
25. Changes in the cytoskeletal structure of human platelets following thrombin activation
26. The function of myosin and myosin light chain kinase phosphorylation in smooth muscle
27. In situ phosphorylation of human platelet myosin heavy and light chains by protein kinase C
28. Isomeric contraction by fibroblasts and endothelial cells in tissue culture: A quantitative study
29. Regulation of actin microfilament integrity in living nonmuscle cells by the cAMP‐dependent protein kinase and the myosin light chain kinase
30. The effects of caldesmon on smooth muscle heavy actomeromyosin ATPase activity and binding of heavy meromyosin to actin
31. Antigen‐induced secretion of histamine and the phosphorylation of myosin by protein kinase C in rat basophilic leukemia cells
32. Calcium dependence of the thrombin‐induced increase in endothelial albumin permeability
33. i and inositol polyphosphates
34. Increased endothelial albumin permeability mediated by protein kinase C activation
35. ++ concentration
36. Phosphorylation‐dependent binding of a synthetic MARCKS peptide to calmodulin
37. Isoproterenol reduces thrombin‐induced pulmonary endothelial permeability in vitro
38. The effect of histamine and cyclic adenosine monophosphate on myosin light chain phosphorylation in human umbilical vein endothelial cells
39. KT5926, a potent and selective inhibitor of myosin light chain kinase
40. Phosphorylation of mammalian myosin light chain kinases by the catalytic subunit of cyclic AMP‐dependent kinase and by cyclic GMP‐dependent protein kinase
41. Protein kinase C modulates in vitro phosphorylation of the smooth muscle heavy meromyosin by myosin light chain kinase
42. Isoproterenol attenuates myosin phosphorylation and contraction of tracheal muscle
43. Regulation of thrombin‐induced endothelial cell activation by bacterial toxins
44. Cholera toxin prevents thrombin‐ and PMA‐induced endothelial cell barrier dysfunction
45. Evans Blue‐albumin binding as a new marker of transendothelial macromolecule permeability
46. Different phosphorylated forms of myosin in contracting tracheal smooth muscle
47. Phallicidin prevents thrombin‐induced increases in endothelial permeability to albumin
48. 2+] determines myosin phosphorylation in agonist‐stimulated swine arterial smooth muscle
49. Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F‐actin, and promotes albumin diffusion across cultured endothelial monolayers
50. Role of actin and myosin in the control of paracellular permeability in pig, rat, and human vascular endothelium
51. Role of endothelial cell cytoskeleton in control of endothelial permeability
52. Reversible oxidant‐induced increases in albumin transfer across cultured endothelium: Alterations in cell shape and calcium homeostasis
53. Adenosine 3′:5′‐monophosphate‐mediated inhibition of myosin light chain phosphorylation in bovine aorti actomyosin
54. Caldesmon: A common actin‐linked regulatory protein in the smooth muscle and nonmuscle contractile system
55. 77 and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers
56. Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties
57. Myosin light chain kinase phosphorylation in tracheal smooth muscle
58. Linear relationship between diphosphorylation of 20 KDa light chain of gizzard myosin and the actin‐activated myosin ATPase activity
59. Effect of multiple phosphorylations of smooth muscle and cytoplasmic myosins on movement in an in vitro motility assay
60. Involvement of myosin light‐chain kinase in endothelial cell retraction
61. Regulation of permeabilized endothelial cell retraction by myosin phosphorylation