1,1- Bisphosphonate Squalene Synthase Inhibitors: Interplay Between the Isoprenoid Subunit and the Diphosphate Surrogate

Journal of Medicinal Chemistry

Volumn 38, Issue 14, 1995, Pages 2596-2605

  Magnin, David R ^a   Biller, Scott A ^a   Dickson, John K ^a   Logan, Janette V ^a   Lawrence, R Michael ^a   Chen, Ying ^a   Sulsky, Richard B ^a   Ciosek, Carl P ^a   Harrity, Thomas W ^a   Jolibois, Kern G ^a   Kunselman, Lori K ^a   Rich, Lois C ^a   Slusarchyk, Dorothy A ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; SQUALENE SYNTHASE; SQUALENE SYNTHASE INHIBITOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYPERCHOLESTEROLEMIA; INHIBITION KINETICS; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ANIMAL; ANTILIPEMIC AGENTS; DIPHOSPHATES; DIPHOSPHONATES; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; POLYISOPRENYL PHOSPHATES; RATS; SQUALENE SYNTHETASE;

EID: 0029011739     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00014a012     Document Type: Article

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