Total Synthesis of Rapamycin and Demethoxyrapamycin

Journal of the American Chemical Society

Volumn 117, Issue 19, 1995, Pages 5407-5408

  Smith, Amos B ^a   Condon, Stephen M ^a   McCauley, John A ^a   Leazer, Johnnie L ^a   Leahy, James W ^a   Maleczka, Robert E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEMETHOXYRAPAMYCIN; RAPAMYCIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0029011702     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja00124a043     Document Type: Article

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22. 2a elegantly extended this methodology with a Stille-type “stitching-cyclization” to install the C(19)—C(20) vinyl unit and simultaneously close the macrocycle in 28% yield.