Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer

New England Journal of Medicine

Volumn 332, Issue 21, 1995, Pages 1393-1398

  Taplin, Mary Ellen ^a   Bubley, Glenn J ^b   Shuster, Todd D ^b   Frantz, Martha E ^b   Spooner, Amy E ^b   Ogata, George K ^b   Keer, Harold N ^b   Balk, Steven P ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; BETA 2 MICROGLOBULIN; COMPLEMENTARY DNA; ESTRADIOL; ESTROGEN; FLUTAMIDE; GONADORELIN ANTAGONIST; LEUPRORELIN; PROGESTERONE; TESTOSTERONE;

ARTICLE; BONE MARROW BIOPSY; BONE MARROW METASTASIS; CANCER HORMONE THERAPY; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; HORMONE DEPENDENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; ORCHIECTOMY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTATE CANCER; TRANSURETHRAL RESECTION;

BASE SEQUENCE; BONE MARROW DISEASES; DNA, COMPLEMENTARY; DNA, NEOPLASM; ESTRADIOL; HUMAN; MALE; MOLECULAR SEQUENCE DATA; NEOPLASM METASTASIS; POINT MUTATION; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TESTOSTERONE; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0029011116     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199505253322101     Document Type: Article

References (35)

1. Boring CC, Squires TS, Tong T Cancer statistics, 1992. CA Cancer J Clin 1992; 42: 19-38 [Erratum, CA Cancer J Clin 1992;42:127-8.]
2. Crawford ED Challenges in the management of prostate cancer. Br J Urol 1992; 70: Suppl 1: 33-38
3. van Tinteren H, Dalesio O Systematic overview (metaanalysis) of all randomized trials of treatment of prostate cancer. Cancer 1993; 72: Suppl: 3847-3850
4. Dawson NA Treatment of progressive metastatic prostate cancer. Oncology 1993; 7: 17-24, 27 [Erratum, Oncology (Huntingt) 1993;7:2.]
5. Scher HI, Kelly WK Flutamide withdrawal syndrome: its impact on clinical trials in hormone-refractory prostate cancer. J Clin Oncol 1993; 11: 1566-1572
6. Cunha GR, Donjacour AA, Cooke PS, The endocrinology and developmental biology of the prostate. Endocr Rev 1987; 8: 338-362
7. Evans RM The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889-895
8. Beato M Gene regulation by steroid hormones. Cell 1989; 56: 335-344
9. Riegman PHJ, Vlietstra RJ, van der Korput JAGM, Brinkmann AO, Trapman J The promoter of the prostate-specific antigen gene contains a functional androgen responsive element. Mol Endocrinol 1991; 5: 1921-1930
10. Huggins C, Stevens RE Jr, Hodges CV Studies on prostate cancer. II. The effects of castration on advanced carcinoma of the prostate gland. Arch Surg 1941; 43: 209-223
11. Colombel M, Olsson CA, Ng PY, Buttyan R Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle. Cancer Res 1992; 52: 4313-4319
12. Marcelli M, Tilley WD, Wilson CM, Griffin JE, Wilson JD, McPhaul MJ Definition of the human androgen receptor gene structure permits the identification of mutations that cause androgen resistance: premature termination of the receptor protein at amino acid residue 588 causes complete androgen resistance. Mol Endocrinol 1990; 4: 1105-1116
13. Lubahn DB, Brown TR, Simental JA, Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity. Proc Natl Acad Sci U S A 1989; 86: 9534-9538 [Erratum, Proc Natl Acad Sci U S A 1990;87:4411.]
14. De Bellis A, Quigley CA, Cariello NF, Single base mutations in the human androgen receptor gene causing complete androgen insensitivity: rapid detection by a modified denaturing gradient gel electrophoresis technique. Mol Endocrinol 1992; 6: 1909-1920
15. Caskey CT, Pizzuti A, Fu Y-H, Fenwick RG Jr, Nelson DL Triplet repeat mutations in human disease. Science 1992; 256: 784-789
16. Newmark JR, Hardy DO, Tonb DC, Androgen receptor gene mutations in human prostate cancer. Proc Natl Acad Sci U S A 1992; 89: 6319-6323
17. Culig Z, Klocker H, Eberle J, DNA sequence of the androgen receptor in prostatic tumor cell lines and tissue specimens assessed by means of the polymerase chain reaction. Prostate 1993; 22: 11-22
18. Culig Z, Hobisch A, Cronauer MV, Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone. Mol Endocrinol 1993; 7: 1541-1550
19. Suzuki H, Sato N, Watabe Y, Masai M, Seino S, Shimazaki J Androgen receptor gene mutations in human prostate cancer. J Steroid Biochem Mol Biol 1993; 46: 759-765
20. Ruizeveld de Winter JA, Janssen PJA, Sleddens HMEB, Androgen receptor status in localized and locally progressive hormone refractory human prostate cancer. Am J Pathol 1994; 144: 735-746
21. Gaddipati JP, McLeod DG, Heidenberg HB, Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. Cancer Res 1994; 54: 2861-2864
22. Veldscholte J, Ris-Stalpers C, Kuiper GGJM, A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens. Biochem Biophys Res Commun 1990; 173: 534-540
23. Porcelli S, Yockey CE, Brenner MB, Balk SP Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- α/β T cells demonstrates preferential use of several V β genes and an invariant TCR α chain. J Exp Med 1993; 178: 1-16
24. Gussow D, Rein R, Ginjaar I, The human β2-microglobulin gene: primary structure and definition of the transcriptional unit. J Immunol 1987; 139: 3132-3138
25. Brinkmann AO, Faber PW, van Rooij HCJ, The human androgen receptor: domain structure, genomic organization and regulation of expression. J Steroid Biochem 1989; 34: 307-310
26. Nordeen SK Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques 1988; 6: 454-458
27. Quarmby VE, Yarbrough WG, Lubahn DB, French FS, Wilson EM Autologous down-regulation of androgen receptor messenger ribonucleic acid. Mol Endocrinol 1990; 4: 22-28
28. Lubahn DB, Joseph DR, Sar M, The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate. Mol Endocrinol 1988; 2: 1265-1275
29. van der Kwast TH, Schalken J, Ruizeveld de Winter JA, Androgen receptors in endocrine-therapy-resistant human prostate cancer. Int J Cancer 1991; 48: 189-193
30. Ris-Staplers C, Verleun-Mooijman MCT, Trapman J, Brinkmann AO Threonine on amino acid position 868 in the human androgen receptor is essential for androgen binding specificity and functional activity. Biochem Biophys Res Commun 1993; 196: 173-180
31. Jenster G, van der Korput HAGM, van Vroonhoven C, van der Kwast TH, Trapman J, Brinkmann AO Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization. Mol Endocrinol 1991; 5: 1396-1404
32. Fuqua SA, Chamness GC, McGuire WL Estrogen receptor mutations in breast cancer. J Cell Biochem 1993; 51: 135-139
33. Karnik PS, Kulkarni S, Liu XP, Budd GT, Bukowski RM Estrogen receptor mutations in tamoxifen-resistant breast cancer. Cancer Res 1994; 54: 349-353
34. McDonnell TJ, Troncoso P, Brisbay SM, Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res 1992; 52: 6940-6944
35. Bookstein R, MacGrogan D, Hilsenbeck SG, Sharkey F, Allred DC p53 Is mutated in a subset of advanced-stage prostate cancers. Cancer Res 1993; 53: 3369-3373