The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

Immunity

Volumn 2, Issue 5, 1995, Pages 493-506

  Read, Margaret A ^a   Neish, Andrew S ^a   Luscinskas, Francis W ^a   Palombella, Vito J ^b   Maniatis, Tom ^c   Collins, Tucker ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b ChemGenics Pharmaceuticals Inc   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CYTOKINE; INTERCELLULAR ADHESION MOLECULE 1; PROTEASOME; PROTEINASE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE; NEUTROPHIL; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

BASE SEQUENCE; CALPAIN; CELL ADHESION; CELL ADHESION MOLECULES; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; E-SELECTIN; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; HUMAN; IN VITRO; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-8; LEUKOCYTES; LEUPEPTINS; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NF-KAPPA B; OLIGODEOXYRIBONUCLEOTIDES; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; TUMOR NECROSIS FACTOR; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0029010658     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/1074-7613(95)90030-6     Document Type: Article

References (71)

1. E-selectin supports neutrophil rolling in vitro under conditions of flow
2. The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors
3. Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions
4. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins
5. Induced expression of endothelial-leukocyte adhesion molecules in human cardiac allografts
6. Mutual regulation of the transcriptional activator NF-κB and its inhibitor, IκBα
7. Leukocyte-endothelial adhesion molecules
8. Adhesion of vascular cell adhesion molecule 1 and fibronectin: comparison of alpha 4 beta 1 and alpha 4 beta 7 on the human cell line JY
9. Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
10. The ubiquitin-proteasome proteolytic pathway
11. Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1
12. A common theme in endothelial activation: insights from the structural analysis of the genes for E-selectin and VCAM-1
13. Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCM1 gene
14. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis
15. Cloning and characterization of the 5′-transcriptional regulatory region of the human intercellular adhesion molecule 1 gene
16. Cytokine-inducible expression in endothelial cells of an IκBα-like gene is regulated by NF-KB
17. Proteolytic processing of NF-κB/IκB in human monocytes
18. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site
19. Inducible phosphorylation of IκBα is not sufficient for its dissociation from NF-κB and is inhibited by protease inhibitors
20. Adhesion of human B-cells to germinal centers in vitro involves V LA-4 and INCAM110
21. Culture of vascular endothelium
22. Vascular endothelium in health and disease
23. Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells
24. Proteolysis, proteasomes and antigen presentation
25. NF-κB and Rel, participants in a multiform transcriptional regulatory system
26. Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding ICAM-1
27. Regulation of transendothelial neutrophil migration by endogenous interleukin-8
28. Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)
29. Neutrophil migration across monolayers of cytokine-prestimulated endothelial cells: a role for platelet-activating factor and IL-8
30. NF-κB subunit-specific regulation of the interleukin-8 promoter
31. Selectins: interpreters of cell-specific carbohydrate information during inflammation
32. Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins
33. Neutrophils roll on E-selectin
34. Cooperativity between two NF-κB complexes mediated by high mobility-group protein I(Y), is essential for cytokine-induced expression of the E-selectin promoter
35. Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium
36. Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, β1 integrins, and β2 integrins
37. + T-lymphocytes on TNF-α activated vascular endothelium under flow
38. PECAM-1 is required for transendothelial migration of leukocytes
39. Activation of NF-κB in vivo is regulated by multiple phosphorylations
40. Functional analysis of the human vascular cell adhesion molecule 1 promoter
41. Endothelial IRF-1 cooperates with NF-κB as a transcriptional activator of vascular cell adhesion molecule-1
42. Calcium-dependent heparin-like ligands for L-selectin in nonlymphoid endothelial cells
43. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
44. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
45. Proteasomes: protein degradation machines of the cell
46. Cytokines and endothelial biology
47. NF-κB and IκBα: an inducible regulatory system in endothelial activation
48. In vivo control of NF-κB and activation by IκBα
49. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class 1 molecules
50. Cell surface lectins in the immune system
51. Three NF-κB binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression
52. The p65 subunit of NF-κB regulates IkB by two distinct mechanisms
53. Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells
54. Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus EIA protein
55. Cooperative interaction of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro
56. Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion
57. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm
58. Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families
59. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-κB
60. NF-κB controls expression of inhibitor IκBa: evidence for an inducible autoregulatory pathway
61. NF-κB: A lesson in family values
62. IκB-β regulates the persistent response in a biphasic activation of NF-κB
63. A proteasome inhibitor prevents activation of NF-κB. and stabilizes a newly phosphorylated form of IκBα that is still bound to NF-κB
64. 12-otetradecanoyl-phorbol-13-acetate and tumor necrosis factor α-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone
65. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region: induction by cytokines and phorbol ester
66. Intercellular adhesion molecule-1 gene expression in human endothelial cells
67. Neutrophil-mediated damage to human vascular endothelium
68. An NF-κB like factor is essential but not sufficient for cytokine induction of endothelial adhesion molecule-1 (ELAM-1)
69. A striking similarity in the organization of the E-selectin and beta interferon gene promoters