Role of cytochrome P450 2C9 and an allelic variant in the 4′-hydroxylation of (R)- and (S)-flurbiprofen

Biochemical Pharmacology

Volumn 49, Issue 9, 1995, Pages 1269-1275

  Tracy, Timothy S ^a   Rosenbluth, Brady W ^a   Wrighton, Steven A ^b   Gonzalez, Frank J ^c   Korzekwa, Kenneth R ^c  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

cDNA expression; cytochrome P450; enantiomers; flurbiprofen; human liver microsomes; vaccinia virus

Indexed keywords

4' HYDROXYFLURBIPROFEN; ALPHA NAPHTHOFLAVONE; COMPLEMENTARY DNA; CYTOCHROME P450 ISOENZYME; DRUG METABOLITE; ERYTHROMYCIN; FLURBIPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; TOLBUTAMIDE; UNCLASSIFIED DRUG; WARFARIN;

AEROBIC METABOLISM; ALLELE; ARTICLE; CONTROLLED STUDY; ENANTIOMER; ENZYME KINETICS; GENE EXPRESSION; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME METABOLISM; PRIORITY JOURNAL; STEREOSPECIFICITY;

CYTOCHROME P-450 ENZYME SYSTEM; FLURBIPROFEN; HUMAN; HYDROXYLATION; MICROSOMES, LIVER; STEREOISOMERISM; STEROID HYDROXYLASES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029010518     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)00048-5     Document Type: Article

References (23)

1. Physiology and treatment of pain and inflammation: Analgesic effects of flurbiprofen
2. The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences
3. Stereoselective pharmacokinetics of flurbiprofen in humans and rats
4. The disposition and metabolism of flurbiprofen in several species including man
5. High-performance liquid Chromatographic analysis of the enantiomers of flurbiprofen and its metabolites in plasma and urine
6. Pharmacokinetics of flurbiprofen in man. I. Area/dose relationships
7. TB (CYP2C): A major monooxygenase catalyzing diclofenac 4′-hydroxylation in human liver
8. TB (CYP2C)
9. Microsomal enzymes involved in toxicology—Analysis and separation
10. Protein measurement with the Folin phenol reagent
11. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
12. Expression of mammalian cytochrome P450 using vaccinia virus
13. Statistical analysis of enzyme kinetic data
14. Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: A role for P-4502C9 in the etiology of (S)-warfarin-drug interactions
15. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily
16. Impaired (S)-warfarin metabolism catalyzed by the R144C allelic variant of CYP2C9
17. Identification of an inducible form of cytochrome P-450 in human liver
18. Multiple forms of cytochrome P-450: Catalytic differences exhibited by two homogeneous forms of rabbit cytochrome P-450
19. Stereoselective arylpropionyl CoA thioster formation in vitro
20. Metabolic enantiomeric interactions: The inhibition of human (S)-warfarin-7-hydroxylase by (R)-warfarin
21. Enantiomer/enantiomer interaction of (S)- and (R)-propafenone for cytochrome P450IID6-catalyzed 5-hydroxylation: In vitro evaluation of the mechanism
22. An enantiomerenantiomer interaction of (S)- and (R)-propafenone modifies the effect of racemic drug therapy
23. Evaluation of triacetyloleandomycin, α-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450