Virtual cofactors for an Escherichia coli nitroreductase enzyme: Relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT)

Biochemical Pharmacology

Volumn 49, Issue 11, 1995, Pages 1641-1647

  Knox, Richard J ^a   Friedlos, Frank ^a   Jarman, Michael ^a   Davies, Lawrence C ^a   Goddard, Phyllis ^a   Anlezark, Gillian M ^b   Melton, Roger G ^b   Sherwood, Roger F ^b  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

bioactivation; bioreduction; CB 1954; NADH; NADPH; nitroreduction; prodrugs

Indexed keywords

1 BETA DEXTRO RIBOFURANOSYL 3 (5 TETRAZOLYL)PYRIDINE; 1 METHYLNICOTINAMIDE; 3 ACETYLPYRIDINE ADENINE DINUCLEOTIDE; 3 ACETYLPYRIDINE RIBOSIDE; 3 ACETYLPYRIDINE RIBOTIDE; 4 METHYLNICOTINIC ACID 5' O BENZOYL RIBOSIDE; 4 METHYLNICOTINIC ACID RIBOSIDE; 5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; ALKYLATING AGENT; BACTERIAL ENZYME; MENADIONE; NICOTINAMIDE 5' O BENZOYL RIBOSIDE; NICOTINAMIDE RIBOSIDE; NICOTINAMIDE RIBOTIDE; NICOTINIC ACID 5' O BENZOYL RIBOSIDE; NICOTINIC ACID RIBONUCLEOSIDE; NICOTINIC ACID RIBONUCLEOTIDE; NITROREDUCTASE; PRODRUG; PYRIDINIUM DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; COENZYME; CONTROLLED STUDY; DRUG HALF LIFE; ELECTRON TRANSPORT; ESCHERICHIA COLI; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTIBODIES; AZIRIDINES; ESCHERICHIA COLI; MICE; NAD; NITROREDUCTASES; OXIDATION-REDUCTION; PRODRUGS; PYRIDINIUM COMPOUNDS; RIBONUCLEOSIDES; SUPPORT, NON-U.S. GOV'T; VITAMIN K;

EID: 0029009389     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)00077-D     Document Type: Article

References (25)

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