Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: Chromosome aberrations after low dose-rate irradiation

International Journal of Radiation Biology

Volumn 67, Issue 5, 1995, Pages 519-528

  Jones, L A ^a   Scott, D ^a   Cowan, R ^a   Roberts, S A ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BREAST CANCER; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LOW ENERGY RADIATION; LYMPHOCYTE; MALE; PRIORITY JOURNAL; RADIATION INJURY; RADIOSENSITIVITY;

ADULT; AGED; ATAXIA TELANGIECTASIA; BREAST NEOPLASMS; CHROMOSOME ABERRATIONS; CHROMOSOMES; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GAMMA RAYS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; LYMPHOCYTES; MALE; METAPHASE; MICRONUCLEUS TESTS; MIDDLE AGE; SUPPORT, NON-U.S. GOV'T; TIME FACTORS;

EID: 0029008814     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553009514550631     Document Type: Article

References (28)

1. Prediction of normal tissue tolerance to radiotherapy from in vitro cellular radiosensitivity
2. The production of micronuclei and chromosome aberrations in irradiated cultures of human lymphocytes
3. A cellular description of the repair of defect in ataxia-telangiectasia
4. Radiosensitivity in ataxia-telangiectasia
5. Cancer risks in A-T heterozygotes
6. Use of low dose rate irradiation to measure the intrinsic radiosensitivity of human T-lymphocytes
7. Measurement of micronuclei in lymphocytes
8. Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients
9. Ataxia-telangiectasia, neoplasia, untoward response to X-irradiation and tuberous schlerosis
10. Comparisons of dose response parameters for radiation induced acentric fragments and micronucleic observed in cytokinesis arrested lymphocytes
11. Chromosome aberrations induced in human lymphocytes by in vitro acute X and gamma radiation
12. In vitro radiosensitivity of human diploid fibroblasts derived from women with unusually sensitive clinical responses to definitive radiation therapy for breast cancer
13. The importance of genetics for the optimisation of radiation therapy
14. The relationship between colony forming ability and chromosomal aberrations induced in human T-lymphocytes with γ-irradiation
15. New Giemsa method for the differential staining of sister chromatids
16. The Christie Hospital breast conservation trial: an update at 8 years from inception
17. Radiation damage and its repair in the formation of chromosome aberrations in human lymphocytes
18. 60Co gamma and X-rays
19. The effect of radiation on the chromosomes of patients with an unusual cancer susceptibility
20. Evidence for individual differences in radiosensitivity of human skin
21. Individual variation and dose dependency in the progression rate of skin telangiectasia
22. Repair capacity and kinetics of human skin during fractionated radiotherapy: erythema, desquamation and telangiectasia after 3 and 5 years follow-up
23. Study of dose-rate and split-dose effects on the in vitro micronucleus yield in human lymphocytes exposed to X-rays
24. Cytogenetic characterisation of ataxia-telangiectasia (AT) heterozygotes using lymphoblastoid cell lines and chronic irradiation
25. Assessment of chronic γ-radiosensitivity as an in vitro assay for heterozygote identification in ataxia-telangiectasia
26. Intrinsic radiosensitivity as a predictor of patient response to radiotherapy
27. The Association for Radiation Research First Workshop Report
28. Cell death: the significance of apoptosis