Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/ζ complex

Journal of Experimental Medicine

Volumn 181, Issue 6, 1995, Pages 1997-2006

  Thome, Margot ^a   Duplay, Pascale ^a,c   Guttinger, Maria ^b   Acuto, Oreste ^a  

^a INSTITUT PASTEUR   (France)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ANTIGEN RECOGNITION; ARTICLE; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SEQUENCE HOMOLOGY; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD; ANTIGENS, CD4; CELL LINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME PRECURSORS; HUMAN; KINETICS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MEMBRANE PROTEINS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN-TYROSINE KINASE; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0029008301     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.181.6.1997     Document Type: Article

References (51)

1. June, C.H., M.C. Fletcher, J.A. Ledbetter, and L.E. Samelson. 1990. Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J. Immunol. 144: 1591-1599.
2. Karnitz, L., S.L. Sutor, T. Torigoe, J.C. Reed, M.P. Bell, D.J. McKean, P.J. Leibson, and R.T. Abraham. 1992. Effects of p56u deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line. Mol. Cell. Biol. 12: 4521-4530.
3. Straus, D.B., and A. Weiss. 1992. Genetic evidence for the involvement of the lek tyrosine kinase in signal transduction through the T cell antigen receptor. Cell. 70: 585-593.
4. fyn). Cell. 65: 281-291.
5. Appleby, M.W., J.A. Gross, M.P. Cooke, S.D. Levin, X. Qian, and R.M. Perlmutter. 1992. Defective T cell receptor signaling in mice lacking the thymic isoform of p59ft*. Cell. 70: 751-763.
6. Stein, P.L., H.-M. Lee, S. Rich, and P. Soriano. 1992. pp59)yn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell. 70: 741-750.
7. Chan, A., B.A. Irving, J.D. Fraser, and A. Weiss. 1991. The f chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc. Natl. Acad. Sci. USA. 88: 9166-9170.
8. Chan, A.C., M. Iwashima, C.W. Turck, and A. Weiss. 1992. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR ζ chain. Cell. 71: 649-662.
9. Kolanus, W., C. Romeo, and B. Seed. 1993. T cell activation by clustered tyrosine kinases. Cell. 74: 171-183.
10. Arpaia, E., M. Shahar, H. Dadi, A. Cohen, and C.M. Roifman. 1994. Defective T cell receptor signalling and CD8+ thymic selection in humans lacking Zap kinase. Cell. 76: 947-958.
11. Chan, A., T.A. Kadlecek, M. Elder, A.H. Filipovich, W.-L. Kuo, M. Iwashima, T.G. Parslow, and A. Weiss. 1994. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science (Wash. DC). 264: 1599-1601.
12. Chan, A.C., N.S.C. van Oers, A. Tran, L. Turka, C.-L. Law, J.C. Ryan, E.A. Clark, and A. Weiss. 1994. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J. Immunol. 152: 4758-4766.
13. syk by T-cell antigen receptor/CD3 stimulation. Proc. Natl. Acad. Sci. USA. 91: 5301-5305.
14. Weiss, A., and D.R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell. 76: 263-274.
15. Baniyash, M., P. Garcia-Morales, E. Luong, L.E. Samelson, and R.D. Klausner. 1988. The T cell receptor zeta chain is tyrosine phosphorylated upon activation. J. Biol. Chem. 263: 18225-18230.
16. Qian, D., I. Griswold-Prenner, M. Rich Rosner, and F.W. Fitch. 1993. Multiple components of the T cell antigen receptor complex become tyrosine phosphorylated upon activation. J. Biol. Chem. 268: 4488-4493.
17. Frank, S.J., C. Cenciarelli, B.B. Niklinska, F. Letourneur, J.D. Ashwell, and A.M. Weissman. 1992. Mutagenesis of T cell antigen receptor zeta chain tyrosine residues. Effects on tyrosine phosphorylation and lymphokine production. J. Biol. Chem. 267: 13656-13660.
18. Koyasu, S., D.J. McConkey, L.K. Clayton, S. Abraham, B. Yandava, T. Katagiri, P. Moingeon, T. Yamamoto, and E.L. Reinherz. 1992. Phosphorylation of multiple CD3f tyrosine residues leads to formation of pp21 in vitro and in vivo. J. Biol. Chem. 267: 3375-3381.
19. Sancho, J., R. Franco, T. Chatila, C. Hall, and C. Terhorst. 1993. The T cell receptor associated CD3-e protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif. Eur. J. Immunol. 23: 1636-1642.
20. Hall, C.G., J. Sancho, and C. Terhorst. 1993. Reconstitution of the T cell receptor zeta-mediated calcium mobilization in nonlymphoid cells. Science (Wish. DC). 261: 915-918.
21. Iwashima, M., B.A. Irving, N.S.C. van Oers, A.C. Chan, and A. Weiss. 1994. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science (Wish. DC). 263: 1136-1139.
22. Straus, D.B., and A. Weiss. 1993. The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation. J. Exp Med. 178: 1523-1530.
23. Wange, R.L., S.N. Malek, S. Desiderio, and L.E. Samelson. 1993. Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells. J. Biol. Chem. 268: 19797-19801.
24. Duplay, P., M. Thome, F. Herve, and O. Acuto. 1994. p56w interacts via its src homology 2 domain with the ZAP-70 kinase. J. Exp Med. 179: 1163-1172.
25. sky through physical association and N-terminal tyrosine phosphorylation. Mol. Cell. Biol. 14: 5249-5258.
26. Janeway, C.A. 1992. The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Immunol. 10: 645-674.
27. Collins, T.L., S. Uniyal, J. Shin, J.L. Strominger, R.S. Mit-tler, and S. Burakoff. 1992. p56w association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation. J. Immunol. 148: 2159-2162.
28. Xu, H., and D.R. Littman. 1993. A kinase-independent function of lck in potentiating antigen-specific T cell activation. Cell. 74: 633-643.
29. De Monte, L.B., P. Nistico, R. Tecce, P. Dellabona, M. Momo, A. Anchini, M. Mariani, P.G. Natali, and F. Malavasi. 1990. Gene transfer by retrovirus-derived shuttle vectors in the generation of murine bispecific monoclonal antibodies. Proc. Natl. Acad. Sci. USA. 87: 2941-2945.
30. Schneider, C., R.A. Newman, D.R. Sutherland, U. Asser, and M.F. Greaves. 1982. A one-step purification of membrane proteins using a high efficiency immunomatrix. J. Biol. Chem. 257: 10766-10769.
31. Law, C.-L., S.P. Sidorenko, K.A. Chandran, K.E. Draves, A.C. Chan, A. Weiss, S. Edelhoff, C.M. Disteche, and E.A. Clark. 1994. Molecular cloning of human Syk. J. Biol. Chem. 269: 12310-12319.
32. Songyang, Z., S.E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W.G. Haser, F. King, T. Roberts, S. Ratnofsky, R.J. Lechleider et al. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell. 72: 767-778.
33. Wange, R.L., A.-N.T. Kong, and L.E. Samelson. 1992. A tyrosine-phosphorylated 70-kDa protein binds a photoaffinity analogue of ATP and associates with both the f chain and CD3 components of the activated T cell antigen receptor. Proc. Natl. Acad. Sci. USA. 267: 11685-11688.
34. Rudd, C.E., O. Janssen, K.V.S. Prasad, M. Raab, A. da Silva, J.C. Telfer, and M. Yamamoto. 1993. src-related protein tyrosine kinases and their surface receptors. Biochem. Biophys. Acta. 1155: 239-266.
35. Beyers, A.D., L.L. Spruyt, and A.F. Williams. 1992. Multimolecular associations of the T cell antigen receptor. Trends Cell Biol. 2: 253-255.
36. Osman, N., S.C. Ley, and M.J. Crumpton. 1992. Evidence for an association between the T-cell receptor/CD3 antigen complex and the CD5 antigen in human T-lymphocytes. Eur. J. Immunol. 22: 2995-3000.
37. Saizawa, K., J. Rojo, and C.A. Janeway, Jr. 1987. Evidence for a physical association of CD4 and the CD3:α:β T-cell receptor. Nature (Lond.). 328: 260-263.
38. Rojo, J.M., K. Saizawa, and C.A.J. Janeway. 1989. Physical association of CD4 and the T cell receptor can be induced by anti-T cell receptor antibodies. Proc. Natl. Acad. Sci. USA. 86: 3311-3315.
39. Mittler, R.S., S.J. Goldman, G.L. Spitalny, and S.J. Burakoff. 1989. T-cell receptor-CD4 physical association in a murine T-cell hybridoma: induction by antigen receptor ligation. Proc. Natl. Acad. Sci. USA. 86: 8531-8535.
40. Collins, T.L., and S.J. Burakoff. 1993. Tyrosine kinase activity of CD4-associated p561ck may not be required for CD4-dependent T-cell activation. Proc. Natl. Acad. Sci. USA. 90: 11885-11889.
41. Ley, S.C., M. Marsh, C.R. Bebbington, K. Proudfoot, and P. Jordan. 1994. Distinct intracellular localization of lck and fyn protein tyrosine kinases in human T lymphocytes. J. Cell Biol. 125: 639-649.
42. Sancho, J., J.A. Ledbetter, M.-S. Choi, S.B. Kanner, J.P. Deans, and C. Terhorst. 1992. CD3-f surface expression is required for CD4-p56w-mediated up-regulation of T cell antigen receptor-CD3 signalling in T cells. J. Biol. Chem. 267: 7871-7879.
43. Dianzani, U., A. Shaw, B.K. Al-Ramadi, R.T. Kubo, and C.A. Janeway, Jr. 1992. Physical interaction of CD4 with the T cell receptor. J. Immunol. 148: 678-688.
44. Harding, C.V., and E.R. Unanue. 1990. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature (Lond.). 346: 574-576.
45. Gallagher, P.F., B. Fazekas de St. Groth, andJ.F.A. Miller. 1989. CD4 and CD8 molecules can physically associate with the same T-cell receptor. Proc. Natl. Acad. Sci. USA. 86: 10044-10048.
46. Diez-Orejas, R., S. Ballester, M.J. Feito, G. Ojeda, G. Criado, M. Ronda, P. Portoles, and J.M. Rojo. 1994. Genetic and immunochemical evidence for CD4-dependent association of p56H with the a/3 T-cell receptor (TCR): regulation of TCR-induced activation. EMBO (Eur. Mol. Biol. Org.) J. 13: 90-99.
47. Burgess, K.E., A.D. Odysseos, C. Zalvan, B.J. Druker, P. Anderson, S.F. Schlossman, and C.E. Rudd. 1991. Biochemical identification of direct physical interaction between the CD4/ p56H and Ti(TCR)/CD3 complexes. Eur. J. Immunol. 21: 1663-1668.
48. Beyers, A.D., L.L. Spruyt, and A.F. Williams. 1992. Molecular associations between the T lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc. Natl. Acad. Sci. USA. 89: 2945-2949.
49. Suzuki, S., J. Kupsch, K. Eichman, and M.K. Saizawa. 1992. Biochemical evidence of the physical association of the majority of CD3 6 chains with the accessory/co-receptor molecules CD4 and CD8 on nonactivated T lymphocytes. Eur. J. Immunol. 22: 2475-2479.
50. Mustelin, T. 1994. T cell antigen receptor signaling: three families of tyrosine kinases and a phosphatase. Cell. 1: 351-356.
51. Elder, M.E., D. Lin, J. Clever, A.C. Chan, T.J. Hope, A. Weiss, and T.G. Parslow. 1994. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science (Wash. DC). 264: 1596-1599.