The binding interactions of Ro 40-5967 at the L-type Ca2+ channel in cardiac tissue

European Journal of Pharmacology

Volumn 280, Issue 2, 1995, Pages 155-158

  Rutledge, Aleta ^a   Triggle, David J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

1,4 Dihydropyridine; Ca2+; Ca2+ channel antagonist; Diltiazem; Ro 40 5967; SR 33557; Verapamil

Indexed keywords

1,4 DIHYDROPYRIDINE RECEPTOR; CALCIUM ANTAGONIST; CALCIUM CHANNEL; DEVAPAMIL; DILTIAZEM; FANTOFARONE; FLUSPIRILENE; ISRADIPINE; MIBEFRADIL; NEW DRUG; RADIOLIGAND; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BINDING SITE; CONTROLLED STUDY; DRUG INHIBITION; HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; ANIMALS, NEWBORN; BENZIMIDAZOLES; BINDING, COMPETITIVE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; COMPARATIVE STUDY; HEART; IN VITRO; KINETICS; MALE; MEMBRANES; MIBEFRADIL; MYOCARDIUM; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; TETRAHYDRONAPHTHALENES;

EID: 0029008141     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00194-P     Document Type: Article

References (24)

1. 3H]-d-cis diltiazem and that of other non-dihydropyridine calcium entry blockers in cardiac sarcolemma
2. 2+ channel antagonist Ro 40-5967 in vascular muscle cells cultured from dog coronary and saphenous arteries
3. Nitrendipine block of cardiac calcium channels high affinity binding to the inactivated state
4. 3H]nitrendipine, to guinea pig ileal smooth muscle
5. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
6. Ro 40-5967: a new nondihydropyridine calcium antagonist
7. Characterization of verapamil binding sites in cardiac membrane vesicles
8. 2+ channels by 1,4-dihydropyridine antagonists and agonists
9. Antischizophrenic drugs of the diphenylbutylpiperidine type act as calcium channel antagonists
10. ++ channel antagonists and by the Ca+ + channel agonist Bay K 8644
11. Substituted diphenylbutylpiperidines bind to a unique high affinity site on the L-type calcium channel
12. 2+ channels of smooth muscle, cardiac muscle and neuronal tissues
13. 2+ inward currents by Ro 40 5967 and verapamil: relation to positive inotropy
14. A practical computer-based approach to the analysis of radioligand binding experiments
15. 2+ channels by Ro 40-5967
16. Cardiovascular profile of Ro 40-5967, a new nondihydropyridine calcium antagonist, delineated in isolated, blood-perfused dog heart
17. 2+ channel blocker with potent vasodilator but weak inotropic action
18. New synthetic ligands for L-type voltage-gated calcium channels
19. Characterization of the binding sites for nimodipine and (−)desmethoxyverapamil in bovine cardiac sarcolemma
20. Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists
21. 2+ channels: identification of receptor sites and analysis of its mode of action
22. Hemodynamic profile of Ro 40-5967 in conscious rats: comparison with diltiazem, verapamil and amlodipine
23. 2+ channel antagonists and activators in cultured neonatal rat ventricular myocytes
24. Pharmacologic and radioligand binding studies of 1,4-dihydropyridines in rat cardiac and vascular preparations: stereoselectivity and voltage-dependence of antagonist and activator interactions