Evidence of a chromatin basis for increased mutagen sensitivity associated with multiple primary malignancies of the head and neck

International Journal of Cancer

Volumn 61, Issue 5, 1995, Pages 738-743

  Pandita, Tej K ^a,b   Hittelman, Walter N ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN;

ARTICLE; ATAXIA TELANGIECTASIA; CANCER RISK; CANCER SUSCEPTIBILITY; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA DAMAGE; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; MULTIPLE CANCER; PRIORITY JOURNAL;

BLEOMYCIN; CELL SURVIVAL; CELL TRANSFORMATION, VIRAL; CHROMATIN; CHROMOSOME ABERRATIONS; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; HEAD AND NECK NEOPLASMS; HUMAN; MUTAGENS; NEOPLASMS, MULTIPLE PRIMARY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0029007320     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.2910610524     Document Type: Article

References (28)

1. X‐ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution
2. High‐resolution measurement of breaks in prematurely condensed chromosomes by differential staining
3. 2 chromatid radiosensitivity and susceptibility to cancer
4. Prematurely condensed chromosomes. A model system for visualizing effects of DNA damage, repair and inhibition at the level of chromosome structure
5. Inhibition of the fast and slow component of chromosome repair (Abstract)
6. Possible role of chromatin alterations in radiosensitivity of ataxia‐telangiectasia
7. Improvements in the premature chromosome condensation technique for cytogenetic analysis
8. Prevention of second primary tumors with isotretinoin in squamous‐cell carcinoma of the head and neck
9. Genetic predispostion to cancer with special reference to mutagen sensitivity
10. Sensitivity to genotoxic effects of bleomycin in humans: possible relationship to environmental carcinogenesis
11. Cytogenetic characterization of 20 lymphoblastoid lines derived from human individuals differing in bleomycin sensitivity
12. 9‐β‐D ‐arabinofuranosyl‐2‐fluoroadenine (F‐Ara‐A) inhibits both the fast and slow components of chromosome repair (Abstract)
13. Prematurely condensed chromosomes and the analysis of DNA and chromosome lesions
14. Mammalian cell fusion: induction of premature chromosome condensation in interphase nuclei
15. Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells
16. The contribution of DNA and chromosome repair deficiencies to the radiosensitivity of ataxia telangiectasia
17. Increased initial levels of chromosome damage and heterogeneous chromosome repair in ataxia telangiectasia heterozygote cells
18. 2 phase X‐irradiation of cells from cancer‐prone individuals implicates deficiency in DNA repair
19. 2 chromosomal radiosensitivity of ataxia‐telangiectasia heterozygotes
20. The level of induced DNA double‐strand breakage correlates with cell killing after X‐irradiation
21. Evidence for a general relationship between the induced level of DNA double‐strand breakage and cell killing after X‐irradiation of mammalian cells
22. A deficiency in chromatin repair, genetic instability, and predisposition to cancer
23. 2 phase X‐irradiation, a marker of the ataxia‐telangiectasia gene
24. Mutagen sensitivity in patients with head and neck cancers: a biological marker for risk of multiple primary malignancies
25. Faster repair of DNA double‐strand breaks in radioresistant human tumor cells
26. Association among DNA/chromosome break rejoining rates, chromatin structure alterations, and radiation sensitivity in human tumor cell lines
27. Anticlastogenic effects of 13‐cis‐retinoic acidin vitro
28. The relationship of DNA and chromosome damage to survival of synchronized X‐irradiated L5178Y cells. I. Initial damage