Hepatocyte Nuclear Factor 3 Determines the Amplitude of the Glucocorticoid Response of the Rat Tyrosine Aminotransferase Gene

DNA and Cell Biology

Volumn 14, Issue 5, 1995, Pages 385-396

  Roux, Jeanne ^a   Pictet, Raymond ^a   Grange, Thierry ^a  

^a INSTITUT JACQUES MONOD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; NUCLEAR FACTOR; NUCLEAR FACTOR 5; NUCLEAR FACTOR III; TRANSCRIPTION FACTOR; TYROSINE AMINOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA FOOTPRINTING; DNA PROTEIN COMPLEX; DNA SEQUENCE; ELECTROPHORETIC MOBILITY; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; BASE SEQUENCE; BINDING SITES; CARCINOMA, HEPATOCELLULAR; CELL LINE; CONSENSUS SEQUENCE; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; GLUCOCORTICOIDS; LIVER; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NUCLEAR PROTEINS; POINT MUTATION; RATS; REGULATORY SEQUENCES, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED; TYROSINE TRANSAMINASE;

EID: 0029004768     PISSN: 10445498     EISSN: 15577430     Source Type: Journal    
DOI: 10.1089/dna.1995.14.385     Document Type: Article

References (61)

1. AHEARN, J.M., BARTOLOMEI, M.S., WEST, M.L., CISEK, L.J., and CORDEN, J.L. (1987). Cloning and sequence analysis of the mouse genomic locus encoding the largest subunit of RNA Polymerase II. J. Biol. Chem. 262, 10695-10705.
2. ARCHER, T.K., LEFEBVRE, P., WOLFORD, R.G., and HAGER, G.L. (1992). Transcription factor loading on the MMTV promoter: a bimodal mechanism for promoter activation. Science 255, 1573-1576.
3. AUGE-GOUILLOU, C., PETROPOULOS, I., and ZAKIN, M.M. (1993). Liver-enriched HNF-3a and ubiquitous factors interact with the human transferrin gene enhancer. FEBS Lett. 322, 4-10.
4. BEATO, M. (1989). Gene regulation by steroid hormones. Cell 56, 335-344.
5. BEN-LEVY, R., FAKTOR, O., BERGER, I., and SHAUL, Y. (1989). Cellular factors that interact with the hepatitis B virus enhancer. Mol. Cell. Biol. 9, 1804-1809.
6. BRUNEL, F., OCHOA, A., SCHAEFFER, E., BOISSIER, F., GUILLOU, Y., CEREGHINI, S., COHEN, G.N., and ZAKIN, M.M. (1988). Interactions of DNA-binding proteins with the 5' region of the human transferrin gene. J. Biol. Chem. 263, 10180-10185.
7. CARR, K.D., and RICHARD-FOY, H. (1990). Glucocorticoids locally disrupt an array of positioned nucleosomes on the rat tyrosine aminotransferase promoter in hepatoma cells. Proc. Natl. Acad. Sci. USA 87, 9300-9304.
8. CLARK, K.L., HALAY, E.D., LAI, E., and BURLEY, S.K. (1993). Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature 364, 412-420.
9. CORDINGLEY, M.G., RIEGEL, A.T., and HAGER, G.L. (1987). Steroid-dependent interaction of transcription factors with the inductible promoter of mouse mammary tumor virus in vivo. Cell 48, 261-270.
10. COSTA, R.H., GRAYSON, DR., and DARNELL, J.E. (1989). Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha-1-antitrypsin genes. Mol. Cell. Biol. 9, 1415-1425.
11. COSTA, R.J., GRAYSON, D.R., XANTHOPOULOS, K.G., and DARNELL, J.E. (1988). A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha-1-antitrypsin, albumin, and SV40 genes. Proc. Natl. Acad. Sci. USA 85, 3840-3844.
12. DREWES, T., KLEIN-HITPASS, L., and RYFFEL, G.U. (1991). Liver specific transcription factors of the HNF3-, C/EBP- and LFB1-families interact with the A-activator binding site. Nucleic Acids Res. 19, 6383-6389.
13. ESPINAS, M.L., ROUX, J., GHYSDAEL, J., PICTET, R., and GRANGE, T. (1994). Participation of Ets transcription factor in the glucocorticoid response of rat tyrosine aminotransferase gene. Mol. Cell. Biol. 14, 4116-4125.
14. GRANGE, T., ROUX, J., FROMONT-RACINE, M., and PICTET, R. (1989a). Positive and negative regulation of a transfected chimeric tyrosine aminotransferase gene: effect of copy number. Exp. Cell Res. 180, 220-233.
15. GRANGE, T., ROUX, J., RIGAUD, G., and PICTET, R. (1989b). Two remote glucocorticoid responsive units interact cooperatively to promote glucocorticoid induction of rat tyrosine aminotransferase gene expression. Nucleic Acids Res. 17, 8695-8709.
16. GRANGE, T., ROUX, J., RIGAUD, G., and PICTET, R. (1991). Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific factor. Nucleic Acids Res. 19, 131-139.
17. GRANNER, D.K., and HARGROVE, J.L. (1983). Regulation of the synthesis of tyrosine aminotransferase: the relationship to mRNA-TAT. Mol. Cell. Biochem. 53/54, 113-128.
18. GREENGARD, O. (1969). Enzymic differentiation in mammalian liver. Injection of fetal rats with hormones causes the premature formation of enzymes. Science 163, 891-895.
19. JACKSON, D. A., ROWADER, K.E., STEVENS, K., JIANG, C., MILOS, P., and ZARET, K.S. (1993). Modulation of liver-specific transcription by interactions between hepatocyte nuclear factor 3 and nuclear factor 1 binding DNA in close apposition. Mol. Cell. Biol. 13, 2401-2410.
20. JANTZEN, H.M., STRAHLE, U., GLOSS, B., STEWART, F., SCHMID, W., BOSHART, M., MIKSICEK, R., and SCHUTZ, G. (1987). Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene. Cell 49, 29-38.
21. KAWAGUCHI, H., ASAI, A., OHTSUKA, Y., WATANABE, H., WADA, T., and HANDA, H. (1989). Purification of DNA-binding transcription factors by their selective adsorption on the affinity latex particles. Nucleic Acids Res. 17, 6229-6240.
22. KNOWLES, B.B., HOWE, C.C., and ADEN, D.P. (1980). Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209, 497-499.
23. KUNKEL, T.A., ROBERTS, J.D., and ZAKOUR, R.A. (1987). Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 154, 367-382.
24. KUO, C.J., CONLEY, P.B., CHEN, L., SLADEK, F., DARNELL, J.E., and CRABTREE, G.R. (1992). A transcriptional hierarchy involved in mammalian cell-type specification. Nature 355, 457-461.
25. LADIAS, J.A.A., and KARATHANASIS, S.K. (1991). Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. Science 251,561-565.
26. LAI, E., and DARNELL, J.J. (1991). Transcriptional control in hepatocytes: A window on development. Trends Biochem. Sci. 16, 427-430.
27. LAI, E., PREZIOSO, V.R., SMITH, E., LITVIN, O., COSTA, R.H., and DARNELL, J.E. (1990). Hnf-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally. Genes & Dev. 4, 1427-1436.
28. LAI, E., PREZIOSO, V.R., TAO, W.F., CHEN, W.S., and DARNELL, J.E.J. (1991). Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes & Dev. 5, 416-427.
29. LAI, E., CLARK, K.L., BURLEY, S.K., and DARNELL, J.E. (1993). Hepatocyte nuclear factor 3/fork head or “winged helix” proteins: a family of transcription factors of diverse biologic function. Proc. Natl. Acad. Sci. USA 90, 10421-10423.
30. LANDSCHULZ, W.H., JOHNSON, P.F., ADASHI, E.Y., GRAVES, B.J., and McKNIGHT, S.L. (1988). Isolation of a recombinant copy of the gene coding C/EBP. Genes & Dev. 2, 786-800.
31. LEMAIGRE, F.P., DURVIAUX, S.M., and ROUSSEAU, G.G. (1993). Liver-specific factor binding to the liver promoter of a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. J. Biol. Chem. 268, 19896-19905.
32. LICHSTEINER, S., WUARIN, J., and SCHIBLER, U. (1987). The interplay of DNA-binding proteins on the promoter of the mouse albumin gene. Cell 51, 963-973.
33. LIU, J.K., DIPERSIO, C.M., and ZARET, K.S. (1991). Extracellular signals that regulate liver transcription factors during hepatic differenciation in vitro. Mol. Cell. Biol. 11, 773-784.
34. LUISI, B.F., XU, W.X., OTWINOWSKI, Z., FREEDMAN, L.P., YAMAMOTO, K.R., and SIGLER, P.B. (1991). Cristallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352, 497-505.
35. mcpherson, c.e., shim, e.y., friedman, d.s., and ZARET, K.S. (1993). An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleoso-mal array. Cell 75, 387-398.
36. MONACI, P., NICOSIA, A., and CORTESE, R. (1988). Two different liver-specific factors stimulate in vitro transcription from the human alpha-1-antitrypsin promoter. EMBO J. 7, 2075-2087.
37. MURAKAMI, T., NISHIYORI, A., TAKIGUCHI, M., and MORI, M. (1990). Promoter and 11-kilobase upstream enhancer elements responsible for hepatoma cell-specific expression of the rat ornithine transcarbamylase gene. Mol. Cell. Biol. 10, 1180-1191.
38. NITSCH, D., BOSHART, M., and SCHUTZ, G. (1993a). Activation of the tyrosine aminotransferase gene is dependent on synergy between liver-specific and hormone-responsive elements. Proc. In till. Sci. USA 90, 5479-5483.
39. NITSCH, D., BOSHART, M., and SCHUTZ, G. (1993b). Extinction of tyrosine aminotransferase gene activity in somatic cell hybrids involves modification and loss of several essential transcriptional activators. Genes & Dev. 7, 308-319.
40. NORDEEN, S.K., SUH, B.J., KUHNEL, B., and HUTCHISON, C. A. (1990). Structural determinants of a glucocorticoid receptor recognition element. Mol. Endocrinol. 4, 1866-1873.
41. ODDOS, J., GRANGE, T., CARR, K.D., MATTHEWS, B., ROUX, J., RICHARD-FOY, H., and PICTET, R. (1989). Nucleotide sequence of 10 kilobases of rat tyrosine aminotransferase gene 5' flanking region. Nucleic Acids Res. 17, 8877-8878.
42. OVERDIER, D., PORCELLA, A., and COSTA, R.H. (1994). The DNA-binding specificity of the hepatocyte nuclear factor 3/fork head domain is influenced by amino acid residues adjacent to the recognition helix. Mol. Cell. Biol. 14, 2755-2766.
43. PANI, L., OVERDIER, D.G., PORCELLA, A., QIAN, X., LAI, E. and COSTA, R.H. (1992a). Hepatocyte nuclear factor 3 beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein. Mol. Cell. Biol. 12, 3723-3732.
44. PANI, L., QUIAN, X.B., CLEVIDENCE, D., and COSTA, R.H. (1992b). The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3 beta involves a cell-specific factor and positive autoactivation. Mol. Cell. Biol. 12, 552-562.
45. PAULWEBER, B., SANDHOFER, F., and LEVY-WILSON, B. (1993). The mechanism by which the human Apolipoprotein B gene reducer operates involves blocking of transcriptional activation by hepatocyte nuclear factor 3. Mol. Cell. Biol. 13, 1534-1546.
46. PEARCE, D., and YAMAMOTO, K.R. (1993). Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. Science 259, 1161-1165.
47. PINA, B., BRUGGERMEIER, U., and BEATO, M. (1990). Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter. Cell 60, 719-731.
48. RAYMONDJEAN, M., PICHARD, A.L., GREGORI, C., GI-NOT, F., and KAHN, A. (1991). Interplay of an original combination of factors: C/EBP, NFY, HNF3, and HNF1 in the rat aldolase B gene promoter. Nucleic Acids Res. 19,6145-6153.
49. REIK, A., SCHUTZ, G., and STEWART, A.F. (1991). Glucocorticoids are required for the establishment and maintenance of an alteration of chromatin structure: induction leads to a reversible disruption of nucleosomes over an enhancer. EMBO J. 10, 2569-2576.
50. RIGAUD, G., ROUX, J., PICTET, R., and GRANGE, T. (1991). In vivo footprinting of the rat TAT gene: dynamic interplay between the glucocorticoid receptor and a liver-specific factor. Cell 67, 977-986.
51. RUSCONI, S., SEVERNE, Y., GEORGIEV, O., GALLI, I., and WIELAND, S. (1990). A novel expression assay to study transcriptional activators. Gene 89, 211-221.
52. SAWAYA, P.L., STRIPP, B.R., WHITSETT, J.A., and LUSE, D.S. (1993). The lung-specific CC10 gene is regulated by transcription factors from the Ap-1, octamer, and hepatocyte nuclear factor 3 families. Mol. Cell. Biol. 13, 3860-3871.
53. SCHAEFFER, E., BOISSIER, F., PY, M.C., COHEN, G.N., and ZAKIN, M.M. (1989). Cell type-specific expression of the human transferrin gene. J. Biol. Chem. 264, 7153-7160.
54. SCHNEIDER, T.D., and STEPHENS, R.M. (1990). Sequence logos: a new way to display consensus sequences. Nucleic Acids Res. 18, 6097-6100.
55. SCHULE, R., MULLER, M., KALTSCHMID, C., and RENKAWITZ, R. (1988). Many transcription factors interact synergisti-cally with steroid receptors. Science 242, 1418-1420.
56. SLADEK, F.M., and DARNELL, J.E. (1992). Mechanisms of liver-specific gene expression. Curr. Opin. Genet. Dev. 2, 256-259.
57. STEITZ, T.A. (1990). Structural studies of protein-nucleic acid interaction: the sources of sequence-specific binding. Quart. Rev. Biophys. 23, 205-280.
58. STRAHLE, U., SCHMID, W., and SCHUTZ, G. (1988). Synergistic action of the glucocorticoid receptor with transcription factors. EMBO J. 7, 3389-3396.
59. SUCK, D., LAHM, A., and OEFNER, C. (1988). Structure refined to 2A of a nicked DNA octanucleotide complex with DNAse I. Nature 332, 464-468.
60. SZAPARY, D., OSHIMA, H., and SIMONS, S.S. (1993). A new cis-acting element involved in tissue-selective glucocorticoid inducibility of tyrosine aminotransferase gene expression. Mol. Endocrinol. 7, 941-952.
61. ZARET, K.S., LIU, J.K., and DIPERSIO, C.M. (1990). Site-directed mutagenesis reveals a liver transcription factor essential for the albumin transcriptional enhancer. Proc. Natl. Acad. Sci. USA 87, 5469-5473.